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Volume 2 Issue 1, January 2023

We are one

With great joy and excitement, we celebrate our first anniversary.

Image: Heart main image: artacet / iStock / Getty Images Plus. Cover Design: Bethany Vukomanovic

Editorial

  • Nature Cardiovascular Research is one year old. We look back at our first year and look forward to the years to come, grateful to our authors and audience for their contribution and support.

    Editorial

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Comment & Opinion

  • Iron is essential to the production of myocardial energy and proteins critical for cardiovascular function. Nearly 50% of patients with heart failure with reduced ejection fraction (HFrEF) meet current criteria for iron deficiency, and there has been considerable interest in intravenous repletion of iron stores as a therapeutic strategy to improve HFrEF outcomes. However, the data on intravenous iron therapy in HFrEF have been mixed.

    • Konrad T. Sawicki
    • Hossein Ardehali
    Comment
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Research Highlights

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News & Views

  • Regulatory elements including promoters and enhancers control tissue- and context-dependent gene expression. A new study presents an atlas of transcribed regulatory elements in human heart compartments, and their changes in transcription in the failing heart.

    • Vincent M. Christoffels
    • Phil Barnett
    News & Views
  • Pioneering cohort studies including the Framingham Heart Study have led to major insights into cardiovascular disease. However, these studies are underpowered to identify the effects of less common risk factors on human health. This has motivated the development of the UK Biobank, a biomedical database linking health and genetic information in 500,000 individuals.

    • J. Scott Beeler
    • Alexander G. Bick
    • Kelly L. Bolton
    News & Views
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Research Briefings

  • Using cap analysis of gene expression, we have constructed a map of the genome regulatory network (promoters and enhancers) in healthy and failing human hearts. Analysis of this map demonstrates differential transcriptional regulation in cardiac chambers, disease states, and ischemic and non-ischemic cardiomyopathies. This information could lead to tailored therapies.

    Research Briefing
  • Supplementation with the gut microbial-derived metabolites acetate and butyrate has been shown to lower blood pressure in experimental models of hypertension. However, the translational potential of these metabolites has been unexplored. We provide clinical evidence that acetate and butyrate lower blood pressure in untreated patients with hypertension.

    Research Briefing
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Reviews

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Research

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