Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Goerlich et al. review the current knowledge of the cardiovascular complications of the post-COVID condition, including postural orthostatic tachycardia syndrome, myocardial injury, heart failure, myocarditis and arrhythmias, highlighting currently available and potential treatments.
Xie et al. discuss the strengths and limitations of induced cardiomyocyte-like cell reprogramming, the progress made in the past decade, with a focus on single-cell '-omics' research, and the obstacles that remain to be overcome for clinical application.
Raposo-Gutiérrez et al. review the recent knowledge on adaptive immunity in atherosclerosis, the identity of antigens driving the immune response and how to exploit antigen specificity in possible immunomodulatory strategies, including vaccination.
Abraham and colleagues review the recent developments and future strategies to therapeutically target the endothelin pathway for a broad spectrum of cardiovascular diseases.
Wang, Brady, et al. review the current knowledge on how ECM mechanics regulate vascular homeostasis and dysfunction and the approaches available to examine ECM mechanisms at tissue and cellular levels and to model pathological cell–ECM mechanical interactions for therapeutic applications.
Aitken and colleagues discuss the current understanding of how endothelial cells sense blood flow, focusing on the mechanosensing and mechanotransduction molecules and mechanisms, and highlighting challenges and outstanding questions that should lead future research efforts.
Lopaschuk and Dyck review the bioenergetic and signaling effects of ketones on the cardiovascular system and discuss the potential application of ketones for treating cardiovascular diseases.
Conlon and Arnold discuss the sex differences in cardiac physiology and pathology, the sex-chromosome pathways underlying such differences, and future studies that are needed to assess how cardiac sex differences are maintained and propagated.
Wen Tan et al. review the current technologies available for single-cell transcriptomics, epigenomics and multi-omics analyses, their impact on the cardiovascular research and possible future applications.
In this Review, the authors provide an overview of the critical studies reporting Cre and CreER toxicity in the cardiovascular system, discuss the mechanisms proposed to underlie Cre toxicity and highlight the need to understand, eliminate and control for Cre/CreER toxicity in each experimental model.
Goerlich et al. review the history of cardiac allo- and xenotransplants, the progress in immunomodulation to prevent rejection, the regulatory requirements for clinical application and the lessons learned from the first genetically modified pig-to-human heart xenotransplantation.
In this Review, the authors provide an overview of the pathogenic effects of somatic activating PIK3CA mutations in congenital disorders and discuss how the interplay between genetics, cell identity and the environment explains the onset, progression and severity of these disorders with a special focus on the vasculature.
Libby and Tokgözoğlu discuss the management of atherogenic lipoproteins, notably low-density lipoprotein, with an emphasis on the role of strategies that target PCSK9.
In this Review, the authors provide an overview of the clinical and experimental studies supporting the notion that allergic asthma and associated allergies affect the prevalence, incidence and progression of cardiovascular disease.
Ziad Mallat and Christoph Binder discuss the current knowledge of the adaptive immune response in the immuno-cardiovascular unit, in health and in atherosclerotic disease.
In this Review, Banning and colleagues summarize diagnostic techniques that assess microcirculation in each specific organ, critically appraise all the evidence that supports the systemic and multi-organ nature of microvascular dysfunction and focus on current and emerging interventions for the treatment of microvascular dysfunction.
In this Review, Bowers et al. discuss how the development of therapeutics to combat cardiac diseases, specifically fibrosis, relies on a deeper understanding of how the cardiac extracellular matrix is intertwined with signaling processes that underlie cardiac cell activation and behavior.
Mauro Giacca and Ajay M. Shah discuss the most recent advances in the bidirectional relationship between COVID-19 and an array of cardiovascular diseases.
