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Ziad Mallat and Christoph Binder discuss the current knowledge of the adaptive immune response in the immuno-cardiovascular unit, in health and in atherosclerotic disease.
In this Review, Banning and colleagues summarize diagnostic techniques that assess microcirculation in each specific organ, critically appraise all the evidence that supports the systemic and multi-organ nature of microvascular dysfunction and focus on current and emerging interventions for the treatment of microvascular dysfunction.
In this Review, Bowers et al. discuss how the development of therapeutics to combat cardiac diseases, specifically fibrosis, relies on a deeper understanding of how the cardiac extracellular matrix is intertwined with signaling processes that underlie cardiac cell activation and behavior.
Mauro Giacca and Ajay M. Shah discuss the most recent advances in the bidirectional relationship between COVID-19 and an array of cardiovascular diseases.
Joseph A. Hill and colleagues discuss basic and translational data focusing on the most common form of heart failure with preserved ejection fraction (HFpEF), cardiometabolic HFpEF, emphasizing the bidirectional cross-talk between metabolic dysregulation triggering immune events—and vice versa—in syndrome pathogenesis.
In this Review, Hwa and colleagues summarize the latest advances in platelet biology and function and appraise the technical and biological challenges in platelet investigations.
Alan Tall and Jose Fuster review the latest advances in our knowledge of the function of clonal hematopoiesis in cardiovascular disease and discuss the translation of this knowledge into therapeutics.
This Review discusses the physical concepts and descriptions of the structures that determine myocardial stiffness, different techniques used to estimate myocardial stiffness, and their application in clinical medicine.
