Volume 4

  • No. 5 May 2023

    Intercellular mitochondrial transfer in glioblastoma

    Astrocyte mitochondria can be horizontally transferred to glioblastoma cells, leading to changes in mitochondrial respiration and metabolism that promote proliferation and tumor growth.

    See Watson et al. and the accompanying News & Views article by Semenzato and Scorrano

  • No. 4 April 2023

    The immunology of breast cancer histologic subtypes

    This multispectral image shows a section of invasive ductal breast carcinoma, with infiltration of CD8+ T cells and macrophages in the tumor bed, and lymphoid aggregates in the stroma.

    See Onkar et al.

  • No. 3 March 2023

    Apoptotic cell death promotes metastasis of surviving neighbors

    Dying tumor cells promote pro-metastatic signaling in surviving neighbor cells by releasing extracellular DNA–protein complexes enriched in RAGE ligands.

    See Park et al.

  • No. 2 February 2023

    Identifying master kinases in cancer with integrative multi-omics

    A kinase–substrate–phosphosite network interactome identifies master kinases specific for glioblastoma subtypes, as potential therapeutic targets.

    See Migliozzi et al.

  • No. 1 January 2023

    Multiomics of metastatic breast cancer from the AURORA US Network

    The AURORA US Metastasis Project presents a multiplatform resource of paired primary and metastatic breast cancers, to deepen insights into the molecular underpinnings of metastasis.

    See Garcia-Recio et al.