Pan-cancer genomic landscapes of advanced tumors after therapy
Pleasance et al. report that the mutation spectrum in advanced and treated cancers varies substantially across tumor types and is shaped by external mutagens such as cancer therapies.
Each ellipse system represents the mutation spectrum of an individual patient in the POG570 cohort, with the opacity of each system representing the duration since the diagnosis of advanced disease. Each ellipse within a system depicts a specific base change, scaled by the number of mutations that exhibit that change and angled by the proportion of mutations in that sample that contribute to that change.
See Pleasance et al. and the News & Views article by Rheinbay