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Volume 1 Issue 10, October 2020

Volume 1 Issue 10

Aging-induced metabolic rewiring accelerates tumor growth

Age-associated loss of mitochondrial complex I and IV in human colonic crypts induces metabolic remodelling, including upregulation of PHGDH, resulting in favorable metabolic conditions for tumor growth.

See Smith et al. and the accompanying News & Views by Prag and Murphy

Image: Anna Smith and the Bioimaging Unit, Newcastle University. Cover Design: Lauren Heslop.


  • Editorial |

    Postdoctoral researchers face substantial challenges and stresses that have been exacerbated by the COVID-19 pandemic. Positive action is needed from research institutions, funders and individual investigators to support postdocs and fortify the research endeavor.

News & Views

  • News & Views |

    Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.

    • Anandani Nellan
    • Terry J. Fry
  • News & Views |

    Mitochondrial DNA damage, metabolic disruption and aging have all been associated with cancer. These three threads are now woven together to show that aging-associated somatic mutations to mitochondrial DNA alter mitochondrial serine metabolism to support cell transformation and colon-cancer development.

    • Hiran A. Prag
    • Michael P. Murphy
  • News & Views |

    Cancer has found a formidable foil in COVID-19, and this has brought to the fore the early concerns that COVID-19 could have a deeper impact on oncology patients. Two studies now provide insights into the enigma surrounding the determinants of the worsening of COVID-19 symptoms in patients with cancer.

    • Vivek Subbiah


  • Review Article |

    Zitvogel and colleagues discuss the interplay between cancer and COVID-19 with respect to patient risk and prognosis, immune responses and potential therapies.

    • Lisa Derosa
    • Cléa Melenotte
    • Laurence Zitvogel



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