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Zhang and colleagues analyze single-cell data from patients treated with immunotherapy in five cancer types and find that CXCL13-expressing subsets are implicated in response to treatment in the CD8+ and CD4+ T cell compartments.
Bao et. al. develop the algorithm Starfish, to identify six signatures of complex genomic rearrangements in human cancer genomics datasets, including a pattern called hourglass chromothripsis which is prominent in prostate cancer.