Malladi and colleagues show that inhibiting DRP1 limits mitochondrial plasticity, resulting in increased mitochondrial fusion, impaired fatty acid oxidation and reduced metastasis formation in breast cancer models.

Mitsiades and colleagues utilize functional genomics data in over 700 cancer cell lines, to identify genes with preferentially essential functions in multiple myeloma, which may represent targets for precision medicine strategies.

Bousso and colleagues show that IFN-γ production is the dominant tumor elimination mechanism exerted by CD4⁺ CAR T cells and define tumor cell sensitivity to IFN-γ as a determinant of CD4⁺ CAR T efficacy.

Rebbeck, Huang and colleagues discuss recent insights into health inequities related to clinical next-generation sequencing for precision oncology, the contributing factors as well as recommendations for resolution looking ahead.

Malladi and colleagues show that inhibiting DRP1 limits mitochondrial plasticity, resulting in increased mitochondrial fusion, impaired fatty acid oxidation and reduced metastasis formation in breast cancer models.

Bousso and colleagues show that IFN-γ production is the dominant tumor elimination mechanism exerted by CD4⁺ CAR T cells and define tumor cell sensitivity to IFN-γ as a determinant of CD4⁺ CAR T efficacy.

Mitsiades and colleagues utilize functional genomics data in over 700 cancer cell lines, to identify genes with preferentially essential functions in multiple myeloma, which may represent targets for precision medicine strategies.

Joyce and colleagues use bulk and single-cell profiling of T cell phenotypes in human samples from primary brain tumors and brain metastases as a resource for understanding the biology and therapeutic relevance of the brain tumor microenvironment.

Merbl and colleagues demonstrate that high expression of the proteasome regulator PSME4 is associated with immune-cold lung tumors and reduced antitumor immune responses, by functioning to modulate the protein degradome and antigen diversity.

Watson et al. demonstrate that astrocyte mitochondria can be horizontally transferred to glioblastoma cells in a GAP43-dependent manner, leading to changes in mitochondrial respiration and metabolism that promote proliferation and tumor growth.

What are the elements of a well-written, informative and widely accessible paper?

Charles Rudin completed his MD, PhD, medical and oncology training at the University of Chicago, where he joined the department of medicine faculty in 1998. He directed the lung, esophageal and head and neck cancer program at Johns Hopkins University from 2003 to 2013, while also serving as associate cancer center director for clinical research. He joined Memorial Sloan Kettering Cancer Center in 2013 as chief of thoracic oncology, co-director of the Druckenmiller Center for Lung Cancer Research, and the Sylvia Hassenfeld Chair in Lung Cancer Research.

Mark A. Dawson obtained his medical degree from the University of Melbourne, followed by a PhD from the University in Cambridge. From 2010 to 2014, he was a Wellcome-Beit fellow at the University of Cambridge, and thereafter he joined the Peter MacCallum Cancer Centre as a consultant hematologist and group leader of the cancer epigenetics laboratory. In 2016, he was appointed co-program head of the Cancer Biology and Therapeutics Program, and in 2019 as associate director for research.

Recent progress in melanoma treatment is based on research that poorly represents global population diversity, with little focus on relevant subtypes for non-European and admixed populations. However, there is an opportunity to change this and contribute to a more accurate understanding of melanoma worldwide.

Elaine R. Mardis earned her PhD at the University of Oklahoma, in the laboratory of Bruce Roe. After postgraduate work at Bio-Rad Laboratories in California, she joined the Washington University School of Medicine faculty in 1993. In 2016, she moved to Nationwide Children’s Hospital and is a Professor of Pediatrics at The Ohio State University. She was elected to the US National Academy of Medicine in 2019.

What are the dos and don’ts of cover letters and how can authors maximize their value?