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Launching in January 2020 Nature Cancer is an online journal publishing original research, news and comment across the spectrum of cancer research, from preclinical to translational and clinical work.

Browse Articles

  • Article |

    Ribas and colleagues report that inhibition of PAK4 improves response to anti-PD-1 immunotherapy by reducing Wnt pathway activation and increasing tumor infiltration by T cells.

    • Gabriel Abril-Rodriguez
    • , Davis Y. Torrejon
    • , Wei Liu
    • , Jesse M. Zaretsky
    • , Theodore S. Nowicki
    • , Jennifer Tsoi
    • , Cristina Puig-Saus
    • , Ignacio Baselga-Carretero
    • , Egmidio Medina
    • , Michael J. Quist
    • , Alejandro J. Garcia
    • , William Senapedis
    • , Erkan Baloglu
    • , Anusha Kalbasi
    • , Gardenia Cheung-Lau
    • , Beata Berent-Maoz
    • , Begoña Comin-Anduix
    • , Siwen Hu-Lieskovan
    • , Cun-Yu Wang
    • , Catherine S. Grasso
    •  & Antoni Ribas
  • Analysis |

    Martínez-Jiménez et al. report how disruption of the ubiquitin–proteasome system affects cancer, estimating that >10% of driver mutations involve alterations in genes relevant in ubiquitin-mediated proteolysis, including E3 ligases and their targets.

    • Francisco Martínez-Jiménez
    • , Ferran Muiños
    • , Erika López-Arribillaga
    • , Nuria Lopez-Bigas
    •  & Abel Gonzalez-Perez
  • Article |

    Wu et al. develop trispecific antibodies that recognize CD38, CD3 and CD28 and induce T cell activation and co-signaling. They show in mice and non-human primates that by engaging multiple targets, these antibodies induce enhanced tumor-cell killing.

    • Lan Wu
    • , Edward Seung
    • , Ling Xu
    • , Ercole Rao
    • , Dana M. Lord
    • , Ronnie R. Wei
    • , Virna Cortez-Retamozo
    • , Beatriz Ospina
    • , Valeriya Posternak
    • , Gregory Ulinski
    • , Peter Piepenhagen
    • , Elisa Francesconi
    • , Nizar El-Murr
    • , Christian Beil
    • , Patrick Kirby
    • , Aiqun Li
    • , Jennifer Fretland
    • , Rita Vicente
    • , Gejing Deng
    • , Tarik Dabdoubi
    • , Beatrice Cameron
    • , Thomas Bertrand
    • , Paul Ferrari
    • , Stéphanie Pouzieux
    • , Cendrine Lemoine
    • , Catherine Prades
    • , Anna Park
    • , Huawei Qiu
    • , Zhili Song
    • , Bailin Zhang
    • , Fangxian Sun
    • , Marielle Chiron
    • , Srinivas Rao
    • , Katarina Radošević
    • , Zhi-yong Yang
    •  & Gary J. Nabel