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Volume 3 Issue 9, September 2019

Barcoded DNA structures for the subcellular profiling of proteins

This issue highlights tumour-cell-derived microparticles as efficient drug-delivery carriers, the boosting of chemotherapy in colonic tumours via the phage-guided modulation of gut microbiota, the delivery of a therapeutic monoclonal antibody to metastases in the central nervous system, the augmentation of canonical Wnt signalling to produce cell factories of therapeutically potent exosomes, integrated glass microelectrodes for in vivo brain electrophysiology, and barcoded DNA nanostructures for the profiling of subcellular protein distribution.

The cover illustrates tetrahedral DNA nanostructures that act as barcodes for the high-throughput multiplexed profiling of the subcellular expression and distribution of proteins in cells.

See Sundah et al.

Image: Zac Goh, National University of Singapore. Cover design: Alex Wing.


  • Translational cancer nanomedicine needs to increasingly exploit newly discovered tumour-targeting strategies as well as the further optimization of proven means to selectively increase the concentration of cytotoxic drugs in solid tumours.



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News & Views

  • The localization of target proteins, at subcellular resolution, in fixed patient-derived tissues can now be achieved via antibodies conjugated with tetrahedral DNA nanostructures self-assembled in situ.

    • Yizhe Zhang
    • Alden Moss
    • Amy E. Herr


    News & Views
  • Drug-loaded nanoparticles that specifically bind to phages infecting cancer-promoting bacteria found in colonic tumours augment the effects of chemotherapy against colorectal cancer in mice.

    • Nikhil Aggarwal
    • In Young Hwang
    • Matthew Wook Chang
    News & Views
  • A suite of microelectrodes integrated into glass pipettes, for the simultaneous recording of intracellular and extracellular data in the brains of living mice and rats, yields ground-truth data for the validation of the performance of spike-sorting algorithms.

    • Takashi D. Y. Kozai
    • Erin K. Purcell
    News & Views
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