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Whole-brain optoacoustic imaging of neuronal dynamics
This issue highlights dual positron-emission-tomography–near-infrared probes for the visualization of the trafficking dynamics of a model mRNA vaccine in non-human primates, photoacoustic imaging applied to single-cell intratumoral metabolic heterogeneity and to whole-brain snapshots of neuronal calcium activity in mice, the spectral tracing of glucose metabolism in mice, optoacoustic mesoscopy for biomedicine, and a roadmap for the clinical implementation of optical-imaging biomarkers.
The cover illustrates high-resolution snapshots of neuronal calcium activity across the brain acquired via the optoacoustic imaging of live mice expressing a genetically encoded calcium indicator.
The biodistribution of the components of a messenger RNA vaccine following its administration in non-human primates can be non-invasively monitored by labelling the vaccine with a dual radionuclide–near-infrared probe.
This Review summarizes the development of optoacoustic imaging with acoustic resolution and wide-bandwidth ultrasound detection, and the applicability of this mesoscopic imaging modality in the label-free visualization of tissue pathophysiology.