Volume 3 Issue 3, March 2019

Accurate and explainable detection, via deep learning, of acute intracranial haemorrhage from computed tomography images of the head is achievable with small amounts of data for model training.

An inexpensive assay that uses thermophoresis to concentrate cancer extracellular vesicles bound to aptamers specific for target proteins on the vesicles’ surface, can classify cancer patients according to cancer type and stage.

Large-area electrode arrays for epidermal electrophysiology offer new possibilities for the control of prosthetic devices and the monitoring of brain function.

A computationally designed small molecule inhibits the replication of prion-protein aggregates and ameliorates neurological symptoms in mouse and non-human-primate models of transmissible spongiform encephalopathy.

A patch that deposits an array of microneedle tips under the top layer of the skin enables weeks-long delivery of a contraceptive in rats.

By compressing blood vessels and neurons, globular tumours in the brain can cause neuronal damage, which can be partially reversed by relieving the stress via tumour removal or by administering lithium.

An interpretable deep-learning algorithm trained on a small dataset of computed-tomography scans of the head detects acute ICH and classifies the pathology subtypes, with a performance comparable to expert radiologists.

An assay that thermophoretically profiles surface proteins from serum extracellular vesicles labelled with a panel of fluorescent aptamers detects and classifies patients according to cancer type and cancer stage.

Body-scale epidermal electronic interfaces for electrophysiological recordings enable the control of a transhumeral prosthesis, long-term electroencephalography, and simultaneous electroencephalography and structural and functional MRI.

A computationally designed molecular chaperone inhibits the interaction of normal prions with abnormal isoforms associated with transmissible spongiform encephalopathy, prolongs survival in infected mice and limits symptoms in infected macaques.

A microneedle skin patch with rapidly separable, biodegradable polymer needles continuously releases the contraceptive levonorgestrel for over one month in rats.

Solid stress generated by brain tumours can cause neurological dysfunction in patients, and this could be countered by administering lithium, according to magnetic resonance imaging of patient brains and mouse models of human brain tumours.