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Volume 3 Issue 10, October 2019

Traceless isolation of killer T cells via DNA aptamers

This issue highlights an overview of immunotherapies leveraging engineering approaches, the traceless isolation of CD8+ T cells for CAR-T cell therapy, high-throughput immunomagnetic cell sorting implemented in a microfluidic chip, orthologous therapeutic proteins that elude the adaptive immune system, glycosylated peptides for preventing T-cell-mediated diabetes in mice, and a cell-culture system for assembling 3D tissue models by stacking layers containing pre-conditioned microenvironments.

The cover illustrates the isolation of CD8+ T cells by magnetic microbeads functionalized with DNA aptamers that specifically bind to the T-cell marker CD8 and that can be displaced by a complementary oligonucleotide.

See Kacherovsky et al.

Image: Hang Yu Lin. Cover design: Alex Wing

Editorial

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News & Views

  • For genome-wide screens and other applications that require the processing of a large number of cells, the immunomagnetic sorting of cells on a microfluidic chip is a scalable, rapid and cost-efficient alternative to fluorescence-activated cell sorting.

    • Mateusz Legut
    • Neville E. Sanjana
    News & Views
  • Targeting antigens to the liver by glycosylation promotes antigen-specific immune tolerance via the expansion of regulatory T cells and prevents autoimmunity in a mouse model of type-1 diabetes.

    • Derek G. Doherty
    News & Views
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Reviews

  • This Perspective overviews immunotherapies leveraging engineering approaches, including the design of biomaterials, delivery strategies and nanotechnology solutions, for the realization of individualized cancer treatments.

    • Lindsay Scheetz
    • Kyung Soo Park
    • James J. Moon
    Perspective
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Research

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Amendments & Corrections

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