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This issue highlights point-of-care devices for diagnosing aggressive lymphomas and infectious diseases, a first-in-human study of robotic-assisted surgery in the eye, a portable device for the automated manufacturing of therapeutic-grade biologics, a skin-conformable sensor of blood pressure, and a magnetic wire for the intravascular recovery of labelled circulating tumour cells.
The cover illustrates a skin-conformable ultrasonic device that captures the blood-pressure waveform from a deep artery or vein.
A lunchbox-sized device for nucleic acid quantification that can be powered by sunlight, a flame or electricity enables the diagnosis of disease in settings with unreliable power supply.
A holographic approach relying on small-molecule chromogens enables a rapid and inexpensive test for the accurate classification of aggressive lymphoma at the point of care.
A clinical study shows the feasibility and safety of the intratumoral release of an anticancer drug encapsulated in thermosensitive liposomes by heating the patient’s tumour via focused ultrasound.
This Perspective describes the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outlines opportunities for their use in improving the care of sepsis patients.
A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.
A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.
A low-cost point-of-care device that uses contrast-enhanced microholography and deep learning accurately detects aggressive lymphomas in patients referred for aspiration and biopsy of enlarged lymph nodes.
A portable device enables the automated manufacturing of therapeutic-grade biologics in a few hours and under current good-manufacturing-practice conditions.
An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.
A magnetic wire for the intravascular recovery of labelled circulating tumour cells improves cell capture in anaesthetized pigs by up to two orders of magnitude with respect to a standard blood draw.