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This issue highlights low-noise polymer-coated glucose sensors, endovascular stents for focal stimulation of the motor cortex, implantable pre-metastatic niches, tissue-engineered models of the human ventricle, self-repairing engineered skeletal muscle incorporating macrophages, and the modelling of mutation-related cardiomyopathies with engineered cardiac microtissues.
The cover illustrates a scale model of the human left ventricle made of nanofibrous scaffolds and human stem-cell-derived cardiomyocytes, for the study of contractile function and the modelling of arrhythmia induced by structural defects.
Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease.
Coating continuous glucose-monitoring sensors with zwitterionic polymer reduces early inflammatory responses and signal noise after sensor implantation in live animals, and improves the performance of the sensors without the need for additional recalibration.
Minimally invasive intravascular electrodes chronically implanted via the superior sagittal sinus can stimulate the motor cortex of sheep, and elicit muscular activity.
A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.
A tissue-engineered scale model of the human ventricle made of nanofibrous scaffolds and human-stem-cell-derived cardiomyocytes enables the modelling of arrhythmia.
A machine-learning algorithm reliably predicts Cas9-edited genotypes arising from the repair of DNA double-strand breaks in mouse cells and human cells.
Coating the sensor in continuous glucose monitors with a zwitterionic polymer significantly reduces signal noise and the need for frequent device recalibration.
Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.
Hydrogels incorporating human stromal cells and that after implantation in mice recruit cells from an orthotopic human tumour xenograft enable, after the injection of human immune cells, the study of the evolution of pre-metastatic niches.
Scale models of the human left ventricle made of tissue-engineered nanofibrous scaffolds and primary rat cardiomyocytes or human-stem-cell-derived cardiomyocytes enable the study of contractile function and the modelling of structural arrhythmia.
Adult skeletal muscle, engineered from adult-rat myogenic cells, self-repairs after injury in vitro and when implanted in a mouse dorsal skinfold window-chamber model when the tissue incorporates rat or human macrophages.
Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.