Volume 1 Issue 6 June 2017

Volume 1 Issue 6

Long-lasting implanted biomaterials

This focus issue highlights strategies for increasing the functional durability of implanted biomaterials.

The cover illustrates a subcutaneously-implanted scaffold for the study and modulation of a pre-metastatic niche (Review Article).

Image by Katie Aguado.

Editorial

  • Editorial |

    The design of implantable biomaterials with lasting function is rooted in biomolecular and cellular principles.

News & Views

  • News and Views |

    A subcutaneous depot of a diabetes drug fused to a thermosensitive biopolymer leads to blood-glucose control, for over one week after a single injection, in animal models of type-2 diabetes.

    • Omid Veiseh
  • News and Views |

    A universal ‘add-on’ method based on the ultrafast and localized deposition of polydopamine amplifies the sensitivity of a variety of bioassays for clinical diagnostics.

    • Shana O. Kelley
  • News and Views |

    An optimized drug-eluting polymer for the surface of articulating artificial joints may make them infection-free.

    • Noreen J. Hickok
  • News and Views |

    Implanted scaffolds bearing 3D-printed parallel endothelialized channels restore blood perfusion in ischaemic hind limbs and infarcted hearts in rodents.

    • Shahar Ben-Shaul
    • , Shira Landau
    •  & Shulamit Levenberg
  • News and Views |

    A CRISPR-associated nuclease that can promiscuously cleave RNAs enables a rapid and cheap test for the single-molecule detection and single-base discrimination of nucleic acids.

    • Xiaolei Zuo
    • , Chunhai Fan
    •  & Hong-Yuan Chen

Review Article

  • Review Article |

    This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.

    • Brian A. Aguado
    • , Grace G. Bushnell
    • , Shreyas S. Rao
    • , Jacqueline S. Jeruss
    •  & Lonnie D. Shea

Articles

  • Article |

    An optimized formulation of glucagon-like peptide-1 recombinantly fused to an elastin-like polypeptide leads to zero-order release kinetics from a subcutaneous depot and to 10 days of glycaemic control in three mouse models of diabetes.

    • Kelli M. Luginbuhl
    • , Jeffrey L. Schaal
    • , Bret Umstead
    • , Eric M. Mastria
    • , Xinghai Li
    • , Samagya Banskota
    • , Susan Arnold
    • , Mark Feinglos
    • , David D’Alessio
    •  & Ashutosh Chilkoti
  • Article |

    A simple and versatile assay that relies on the bioconjugation capabilities and ultrafast and localized deposition of polydopamine can be plugged into common laboratory bioassays to improve their detection sensitivity by orders of magnitude.

    • Junwei Li
    • , Madison A. Baird
    • , Michael A. Davis
    • , Wanyi Tai
    • , Larry S. Zweifel
    • , Kristina M. Adams Waldorf
    • , Michael Gale Jr
    • , Lakshmi Rajagopal
    • , Robert H. Pierce
    •  & Xiaohu Gao
  • Article |

    In a rabbit model of prosthetic joint infection, optimization of the shape and loading of antibiotic clusters in a polymer implant augments and prolongs antibiotic elution while maintaining implant strength and wear rate.

    • V. J. Suhardi
    • , D. A. Bichara
    • , S. J. J. Kwok
    • , A. A. Freiberg
    • , H. Rubash
    • , H. Malchau
    • , S. H. Yun
    • , O. K. Muratoglu
    •  & E. Oral
  • Article |

    3D-printed grafts with geometrically designed and endothelialized vasculature rescue the perfusion of distal tissues in rodent models of hind limb ischaemia and myocardial infarction, preventing capillary loss, muscle atrophy and loss of function.

    • T. Mirabella
    • , J. W. MacArthur
    • , D. Cheng
    • , C. K. Ozaki
    • , Y. J. Woo
    • , M. T. Yang
    •  & C. S. Chen
  • Article |

    A comparison of the in vivo engraftment of scaffolds containing either an unassembled suspension of human vascular cells or an assembled network of them shows that non-inflammatory host neutrophils are indispensable mediators of vascularization.

    • Ruei-Zeng Lin
    • , Chin Nien Lee
    • , Rafael Moreno-Luna
    • , Joseph Neumeyer
    • , Breanna Piekarski
    • , Pingzhu Zhou
    • , Marsha A. Moses
    • , Monisha Sachdev
    • , William T. Pu
    • , Sitaram Emani
    •  & Juan M. Melero-Martin