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The May issue highlights the potential of optoacoustic imaging for the diagnosis of skin diseases (Article; News & Views) and for whole-body pre-clinical tomography (Article; News & Views).
The cover shows an artistic rendering of a cross-section of human skin as imaged by optoacoustic mesoscopy (Article; News & Views).
Image by Juan Aguirre, Mathias Schwarz & Vasilis Ntziachristos (TUM/HMGU); adapted by Karen Moore.
A system consisting of an aptamer-based microfluidic biosensor and a simple feedback-control algorithm adjusts therapeutic dosing in near real time in small animals.
An intracortical brain–computer interface combined with functional electrical stimulation allows an individual with traumatic spinal cord injury to perform coordinated reaching and grasping movements.
The efficient generation of mature podocytes from induced pluripotent stem cells makes possible the recapitulation of renal blood filtration on a chip.
High-frame-rate, high-resolution photoacoustic computed tomography reveals, for small live animals, the brain's functional connectivity and the dynamics of breathing, blood oxygenation and circulating melanoma cells.
An array of chemically engineered CRISPR RNAs and AsCpf1 messenger RNAs leads to improvements in gene-cutting efficiency up to about 300% with respect to unmodified CRISPR RNA and plasmid-encoding AsCpf1.
Ultra-broadband optoacoustic mesoscopy implemented in a handheld device enables the visualization of vascular patterns in the dermis and sub-dermis of psoriasis patients, and the quantification of inflammatory biomarkers of psoriasis.
An efficient and chemically defined protocol for the differentiation of human induced pluripotent stem cells into podocytes enables the recapitulation of the differential clearance of the human kidney glomerulus in an organ-on-a-chip.
A closed-loop control system measures and adjusts the concentration of a chemotherapeutic in real time and maintains it within a predefined therapeutic window in both rabbits and rats.
Single-impulse photoacoustic computed tomography can, at deep penetration and high resolution and contrast, image the whole-body dynamics of small animals in real time, and track injected cancer cells and image the vasculature of whole rat brains.