Volume 1 Issue 4 April 2017

Volume 1 Issue 4

Early cancer diagnosis

This focus issue highlights advances in the isolation of cancer biomarkers in blood and in diagnostic or imaging probes for the early detection of cancer.

The cover illustrates a lipid-based nanoprobe for the isolation of nanoscale extracellular vesicles (Article; News & Views).

Image by Xin Zou, Yuan Wan and Si-Yang Zheng.

Editorial

  • Editorial |

    The early detection of cancer demands translatable light-emitting or light-collecting probes with unprecedented levels of sensitivity and specificity.

Comment

  • Comment |

    The clinical utility of diagnostic markers extracted from liquid biopsies from cancer patients is hampered by knowledge gaps in biological understanding but can be aided by technological developments.

    • Catherine Alix-Panabières
    •  & Klaus Pantel

News & Views

  • News and Views |

    A fluorescent peptide that blocks the dimerization of a protein associated with the Epstein–Barr virus enables the imaging and growth inhibition of tumours attributed to the pathogen.

    • John G. Kosowicz
    • , Jaeyeun Lee
    •  & Richard F. Ambinder
  • News and Views |

    Functionalized quantum dots emitting short-wavelength infrared light enable small-animal imaging with deep penetration, high spatial resolution and fast acquisition speeds.

    • Eva M. Sevick-Muraca

Articles

  • Article |

    An optical spectroscopic technique and fibre-optic probe, compatible with clinical ultrasound-guided fine-needle aspiration, accurately distinguishes cancerous, precancerous and benign pancreatic cysts.

    • Lei Zhang
    • , Douglas K. Pleskow
    • , Vladimir Turzhitsky
    • , Eric U. Yee
    • , Tyler M. Berzin
    • , Mandeep Sawhney
    • , Shweta Shinagare
    • , Edward Vitkin
    • , Yuri Zakharov
    • , Umar Khan
    • , Fen Wang
    • , Jeffrey D. Goldsmith
    • , Saveli Goldberg
    • , Ram Chuttani
    • , Irving Itzkan
    • , Le Qiu
    •  & Lev T. Perelman
  • Article |

    Nanoscale extracellular vesicles can be efficiently isolated in about 15 minutes, for downstream analyses of nucleic acids and proteins, via spontaneous labelling through a lipid nanoprobe and subsequent magnetic capture of the labelled vesicles.

    • Yuan Wan
    • , Gong Cheng
    • , Xin Liu
    • , Si-Jie Hao
    • , Merisa Nisic
    • , Chuan-Dong Zhu
    • , Yi-Qiu Xia
    • , Wen-Qing Li
    • , Zhi-Gang Wang
    • , Wen-Long Zhang
    • , Shawn J. Rice
    • , Aswathy Sebastian
    • , Istvan Albert
    • , Chandra P. Belani
    •  & Si-Yang Zheng
  • Article |

    A rapid, inexpensive and ultrasensitive assay that uses antibody-conjugated nanoparticle probes on the surface of a sensor chip quantifies tumour-derived extracellular vesicles to detect pancreatic cancer from 1 μl of blood plasma.

    • Kai Liang
    • , Fei Liu
    • , Jia Fan
    • , Dali Sun
    • , Chang Liu
    • , Christopher J. Lyon
    • , David W. Bernard
    • , Yan Li
    • , Kenji Yokoi
    • , Matthew H. Katz
    • , Eugene J. Koay
    • , Zhen Zhao
    •  & Ye Hu
  • Article |

    A carbon nanotube sensor enables real-time optical quantification of hybridization events of microRNA and other oligonucleotides in vivo and in whole urine and serum.

    • Jackson D. Harvey
    • , Prakrit V. Jena
    • , Hanan A. Baker
    • , Gül H. Zerze
    • , Ryan M. Williams
    • , Thomas V. Galassi
    • , Daniel Roxbury
    • , Jeetain Mittal
    •  & Daniel A. Heller
  • Article |

    An optimized nanosensor with tumour-penetrating ligands and with peptide substrates that lead to maximal tumour-specific protease cleavage detects sub-5 mm lesions in human epithelial tumour xenografts and in an orthotopic model of ovarian cancer.

    • Ester J. Kwon
    • , Jaideep S. Dudani
    •  & Sangeeta N. Bhatia
  • Article |

    A peptide-based fluorescent inhibitor of the dimerization of an oncoprotein of the Epstein–Barr virus blocks the proliferation of tumours associated with the virus in mice.

    • Lijun Jiang
    • , Rongfeng Lan
    • , Tao Huang
    • , Chi-Fai Chan
    • , Hongguang Li
    • , Sam Lear
    • , Jingyi Zong
    • , Wing-Yan Wong
    • , Magnolia Muk-Lan Lee
    • , Brandon Dow Chan
    • , Wai-Lun Chan
    • , Wai-Sum Lo
    • , Nai-Ki Mak
    • , Maria Li Lung
    • , Hong Lok Lung
    • , Sai Wah Tsao
    • , Graham S. Taylor
    • , Zhao-Xiang Bian
    • , William C. S. Tai
    • , Ga-Lai Law
    • , Wing-Tak Wong
    • , Steven L. Cobb
    •  & Ka-Leung Wong
  • Article |

    Functionalized InAs quantum dots emitting in the short-wavelength infrared spectral region enable functional biomedical imaging at unprecedentedly high spatial resolution, deep penetration and fast acquisition speeds.

    • Oliver T. Bruns
    • , Thomas S. Bischof
    • , Daniel K. Harris
    • , Daniel Franke
    • , Yanxiang Shi
    • , Lars Riedemann
    • , Alexander Bartelt
    • , Frank B. Jaworski
    • , Jessica A. Carr
    • , Christopher J. Rowlands
    • , Mark W. B. Wilson
    • , Ou Chen
    • , He Wei
    • , Gyu Weon Hwang
    • , Daniel M. Montana
    • , Igor Coropceanu
    • , Odin B. Achorn
    • , Jonas Kloepper
    • , Joerg Heeren
    • , Peter T. C. So
    • , Dai Fukumura
    • , Klavs F. Jensen
    • , Rakesh K. Jain
    •  & Moungi G. Bawendi

Correction