Volume 1 Issue 3 March 2017

Volume 1 Issue 3

Lasting bioelectronic devices

This focus issue highlights engineering advances that lengthen the lifespan of bioelectronics (Editorial, Comment): energy harvesting in the gastrointestinal tract (Article, News & Views), a conformal electromagnetic surface for powering an implanted device (Article, News & Views), and an ultrathin passivating layer for electronic arrays (ArticleNews & Views).

The cover illustrates an ingestible energy-harvesting electrochemical cell (Article, News & Views).

Image by When I Shoot Your Masterpiece / Diemut Strebe

Editorial

Comment

  • Comment |

    Soft integrated electronics packaged with miniaturized modules for wireless power and data transfer are opening up new opportunities for long-term health monitoring and therapy.

    • Jaemin Kim
    • , Roozbeh Ghaffari
    •  & Dae-Hyeong Kim

News & Views

Perspective

  • Perspective |

    This Perspective puts forward the concept of medical-device-on-a-chip, that is, a microphysiological system that leverages organ-on-a-chip technology for the development and testing of medical devices.

    • Allan Guan
    • , Parisa Hamilton
    • , Yi Wang
    • , Maud Gorbet
    • , Zhenyu Li
    •  & K. Scott Phillips

Articles

  • Article |

    An extracorporeal cross-circulation approach enables, in a swine model, 36 hours of normothermic perfusion in healthy lungs, the recovery of injured lungs, and extended therapeutic interventions in all lungs.

    • John D. O’Neill
    • , Brandon A. Guenthart
    • , Jinho Kim
    • , Scott Chicotka
    • , Dawn Queen
    • , Kenmond Fung
    • , Charles Marboe
    • , Alexander Romanov
    • , Sarah X. L. Huang
    • , Ya-Wen Chen
    • , Hans-Willem Snoeck
    • , Matthew Bacchetta
    •  & Gordana Vunjak-Novakovic
  • Article |

    A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.

    • Phillip Nadeau
    • , Dina El-Damak
    • , Dean Glettig
    • , Yong Lin Kong
    • , Stacy Mo
    • , Cody Cleveland
    • , Lucas Booth
    • , Niclas Roxhed
    • , Robert Langer
    • , Anantha P. Chandrakasan
    •  & Giovanni Traverso
  • Article |

    A phased electromagnetic surface that conforms to the body surface can regulate cardiac rhythm in a porcine model through the wireless transmission of power to miniaturized semiconductor devices implanted at depths of over 4 cm.

    • Devansh R. Agrawal
    • , Yuji Tanabe
    • , Desen Weng
    • , Andrew Ma
    • , Stephanie Hsu
    • , Song-Yan Liao
    • , Zhe Zhen
    • , Zi-Yi Zhu
    • , Chuanbowen Sun
    • , Zhenya Dong
    • , Fengyuan Yang
    • , Hung Fat Tse
    • , Ada S. Y. Poon
    •  & John S. Ho
  • Article |

    Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.

    • Hui Fang
    • , Ki Jun Yu
    • , Christopher Gloschat
    • , Zijian Yang
    • , Enming Song
    • , Chia-Han Chiang
    • , Jianing Zhao
    • , Sang Min Won
    • , Siyi Xu
    • , Michael Trumpis
    • , Yiding Zhong
    • , Seung Won Han
    • , Yeguang Xue
    • , Dong Xu
    • , Seo Woo Choi
    • , Gert Cauwenberghs
    • , Matthew Kay
    • , Yonggang Huang
    • , Jonathan Viventi
    • , Igor R. Efimov
    •  & John A. Rogers
  • Article |

    A hydrogel made of crosslinked clusters of highly branched polymers that has ultralow swelling pressure and that forms in 10 minutes despite its low polymer content functions as an artificial vitreous body for over one year without inducing adverse effects.

    • Kaori Hayashi
    • , Fumiki Okamoto
    • , Sujin Hoshi
    • , Takuya Katashima
    • , Denise C. Zujur
    • , Xiang Li
    • , Mitsuhiro Shibayama
    • , Elliot P. Gilbert
    • , Ung-il Chung
    • , Shinsuke Ohba
    • , Tetsuro Oshika
    •  & Takamasa Sakai