Volume 1 Issue 3, March 2017

Soft integrated electronics packaged with miniaturized modules for wireless power and data transfer are opening up new opportunities for long-term health monitoring and therapy.

An implantable soft robotic sleeve restores circulation and muscle function in infarcted pig hearts.

A microfluidic device that integrates mechanical squeezing and electrical stimulation delivers DNA to the nucleus of cells at a rate of millions of cells per minute.

A silicon dioxide passivation layer dramatically lengthens the operational lifetime of flexible electronic arrays for cardiac electrophysiology.

A biosensing device that harvests energy from fluids in the gut is able to wirelessly transmit measurements from the gastrointestinal tract of pigs for over six days.

Phased-array antennas that conform to body surfaces efficiently transfer electromagnetic energy to miniaturized semiconductor devices implanted in pigs.

Extracorporeal cross-circulation between lungs enables the extended support of recipient lungs and the recovery of injured lungs in a swine model.

This Perspective puts forward the concept of medical-device-on-a-chip, that is, a microphysiological system that leverages organ-on-a-chip technology for the development and testing of medical devices.

A biocompatible, energy-harvesting electrochemical cell delivers power to a wireless sensor for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs.

Capacitive coupling between tissue and flexible integrated electronics through a sealing dielectric layer facilitates long-term electrophysiology measurements, as demonstrated in ex vivo Langendorff heart models.

An extracorporeal cross-circulation approach enables, in a swine model, 36 hours of normothermic perfusion in healthy lungs, the recovery of injured lungs, and extended therapeutic interventions in all lungs.

A phased electromagnetic surface that conforms to the body surface can regulate cardiac rhythm in a porcine model through the wireless transmission of power to miniaturized semiconductor devices implanted at depths of over 4 cm.

Rapid DNA expression in millions of cells per minute can be achieved with a microfluidic device that integrates mechanical squeezing of the cells and electric-field-mediated transient disruption of the plasma and nuclear membranes.

A hydrogel made of crosslinked clusters of highly branched polymers that has ultralow swelling pressure and that forms in 10 minutes despite its low polymer content functions as an artificial vitreous body for over one year without inducing adverse effects.