Volume 1 Issue 2 February 2017

Volume 1 Issue 2

Machine learning in healthcare

This focus issue highlights the accelerating power of machine learning (Editorial) in diagnosing rare disease (Article, News & Views), classifying brain tumours (Article, News & Views), and categorizing the activity of spinal motor neurons (Article, News & Views).

The cover illustrates the concept of a cloud-based multihospital collaboration platform powered by artificial intelligence (Article, News & Views).

Image by Haotian Lin

Editorial

News & Views

Perspective

  • Perspective |

    Drawing from recent successes in cancer immunotherapy, this Perspective discusses that effective cancer-nanomedicine therapies can be designed to prime antitumour immunity far from the site of disease.

    • Wen Jiang
    • , Christina A. von Roemeling
    • , Yuanxin Chen
    • , Yaqing Qie
    • , Xiujie Liu
    • , Jianzhu Chen
    •  & Betty Y. S. Kim

Articles

  • Article |

    An artificial intelligence agent integrated with a cloud-based platform for multihospital collaboration performs equally as well as ophthalmologists in the diagnosis of congenital cataracts in a series of online tests and a multihospital clinical trial.

    • Erping Long
    • , Haotian Lin
    • , Zhenzhen Liu
    • , Xiaohang Wu
    • , Liming Wang
    • , Jiewei Jiang
    • , Yingying An
    • , Zhuoling Lin
    • , Xiaoyan Li
    • , Jingjing Chen
    • , Jing Li
    • , Qianzhong Cao
    • , Dongni Wang
    • , Xiyang Liu
    • , Weirong Chen
    •  & Yizhi Liu
  • Article |

    By taking advantage of stimulated Raman spectroscopy and fibre-laser technology, virtual histology images can be obtained in real time in the operating room, with diagnostic quality comparable with that achieved via conventional histopathology.

    • Daniel A. Orringer
    • , Balaji Pandian
    • , Yashar S. Niknafs
    • , Todd C. Hollon
    • , Julianne Boyle
    • , Spencer Lewis
    • , Mia Garrard
    • , Shawn L. Hervey-Jumper
    • , Hugh J. L. Garton
    • , Cormac O. Maher
    • , Jason A. Heth
    • , Oren Sagher
    • , D. Andrew Wilkinson
    • , Matija Snuderl
    • , Sriram Venneti
    • , Shakti H. Ramkissoon
    • , Kathryn A. McFadden
    • , Amanda Fisher-Hubbard
    • , Andrew P. Lieberman
    • , Timothy D. Johnson
    • , X. Sunney Xie
    • , Jay K. Trautman
    • , Christian W. Freudiger
    •  & Sandra Camelo-Piragua
  • Article |

    A man/machine interface based on the activity of spinal motor neurons reinnervating the muscles of a missing limb in amputees enables the generation of neural signals for potential prosthetic control.

    • Dario Farina
    • , Ivan Vujaklija
    • , Massimo Sartori
    • , Tamás Kapelner
    • , Francesco Negro
    • , Ning Jiang
    • , Konstantin Bergmeister
    • , Arash Andalib
    • , Jose Principe
    •  & Oskar C. Aszmann
  • Article |

    A scanning fibre endoscope, combining reflectance and laser-induced fluorescence emission of intrinsic fluorescent constituents in vascular tissue, provides real-time structural, biochemical and biological images of human atherosclerotic plaques.

    • Luis E. Savastano
    • , Quan Zhou
    • , Arlene Smith
    • , Karla Vega
    • , Carlos Murga-Zamalloa
    • , David Gordon
    • , Jon McHugh
    • , Lili Zhao
    • , Michael M. Wang
    • , Aditya Pandey
    • , B. Gregory Thompson
    • , Jie Xu
    • , Jifeng Zhang
    • , Y. Eugene Chen
    • , Eric J. Seibel
    •  & Thomas D. Wang