Volume 1 Issue 1 January 2017

Volume 1 Issue 1

Discovery and technology for human health

This first issue includes the design and operation of a hand-spun paper centrifuge (Video, Article), neurocognitive barriers to technology embodiment (Comment), and Review Articles on biomedical imaging. Please also read our Editorial.

The cover shows an intravital microscopy image of the foreign-body response to an implanted biomaterial (Article, News & Views).

Image by Eleonora Dondossola and Peter Friedl.

Editorial

Comment

News & Views

  • News and Views |

    Conjugation of a diabetes drug with a brush polymer reduces the reactivity of the drug conjugate towards pre-existing polymer antibodies in human plasma and improves the drug's performance in diabetic mice.

    • Kang Choon Lee
    •  & Seulki Lee
  • News and Views |

    Solid stress within tumours can be quantified by measuring their deformation after cutting, slicing or taking a needle biopsy of them.

    • Daniele M. Gilkes
    •  & Denis Wirtz
  • News and Views |

    A chemically defined protocol requiring no animal-derived components allows for the easier derivation and enduring expansion of epicardial cells from human pluripotent stem cells.

    • David T. Paik
    •  & Joseph C. Wu
  • News and Views |

    Intravital microscopy reveals how giant cells and neovascularization drive the fibrotic encapsulation of biomaterials implanted in live animals.

    • Roberto Weigert

Review Articles

Articles

  • Article |

    A hand-powered centrifuge made of two paper discs, string and wooden handles is shown to achieve rotational speeds of 125,000 r.p.m., separate pure plasma from whole blood in less than 1.5 minutes and isolate malaria parasites in 15 minutes.

    • M. Saad Bhamla
    • , Brandon Benson
    • , Chew Chai
    • , Georgios Katsikis
    • , Aanchal Johri
    •  & Manu Prakash
  • Article |

    A fluorescent nanoprobe that amplifies the fluorescent signal in a broad range of tumours allows for real-time tumour-acidosis-guided detection and surgery of occult, less-than-1-mm3 nodules in mice bearing head and neck or breast tumours.

    • Tian Zhao
    • , Gang Huang
    • , Yang Li
    • , Shunchun Yang
    • , Saleh Ramezani
    • , Zhiqiang Lin
    • , Yiguang Wang
    • , Xinpeng Ma
    • , Zhiqun Zeng
    • , Min Luo
    • , Esther de Boer
    • , Xian-Jin Xie
    • , Joel Thibodeaux
    • , Rolf A. Brekken
    • , Xiankai Sun
    • , Baran D. Sumer
    •  & Jinming Gao
  • Article |

    Conjugation of exendin-4 — a drug to treat type 2 diabetes — with a poly(ethylene glycol) (PEG)-based brush polymer reduces the conjugate's reactivity towards anti-PEG antibodies and leads to lower blood glucose levels in mice for up to 5 days after a single injection.

    • Yizhi Qi
    • , Antonina Simakova
    • , Nancy J. Ganson
    • , Xinghai Li
    • , Kelli M. Luginbuhl
    • , Imran Ozer
    • , Wenge Liu
    • , Michael S. Hershfield
    • , Krzysztof Matyjaszewski
    •  & Ashutosh Chilkoti
  • Article |

    Three methods for releasing solid stress in tumours provide two–dimensional mappings, sensitive estimates and in situ quantification of stress-induced tumour deformations — and thus stored elastic energy — via ultrasonography or optical microscopy.

    • Hadi T. Nia
    • , Hao Liu
    • , Giorgio Seano
    • , Meenal Datta
    • , Dennis Jones
    • , Nuh Rahbari
    • , Joao Incio
    • , Vikash P. Chauhan
    • , Keehoon Jung
    • , John D. Martin
    • , Vasileios Askoxylakis
    • , Timothy P. Padera
    • , Dai Fukumura
    • , Yves Boucher
    • , Francis J. Hornicek
    • , Alan J. Grodzinsky
    • , James W. Baish
    • , Lance L. Munn
    •  & Rakesh K. Jain
  • Article |

    TGF-β-signalling inhibitors allow for the long-term expansion of epicardial cells derived from human pluripotent stem cells by means of the temporal modulation of canonical Wnt signalling under chemically defined xeno-free conditions.

    • Xiaoping Bao
    • , Xiaojun Lian
    • , Timothy A. Hacker
    • , Eric G. Schmuck
    • , Tongcheng Qian
    • , Vijesh J. Bhute
    • , Tianxiao Han
    • , Mengxuan Shi
    • , Lauren Drowley
    • , Alleyn T. Plowright
    • , Qing-Dong Wang
    • , Marie-Jose Goumans
    •  & Sean P. Palecek
  • Article |

    A self-adjusting synthetic gene circuit in implanted mammalian cells senses insulin concentration and reverses the insulin-resistance syndrome in three mouse models by coordinating the expression of the insulin-sensitizing compound adiponectin.

    • Haifeng Ye
    • , Mingqi Xie
    • , Shuai Xue
    • , Ghislaine Charpin-El Hamri
    • , Jianli Yin
    • , Henryk Zulewski
    •  & Martin Fussenegger

Video

  • Video |

    A hand-spun centrifuge made of paper and string can separate plasma from whole blood in less than two minutes, and be used to diagnose malaria and other infectious diseases in areas without laboratory resources or electricity.