Volume 1 Issue 10, October 2017

Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

Devices made with resorbable polymers and braided materials can accommodate tissue growth in long-bone and heart-valve animal models.

The genetic, epigenetic and transcriptomic profiles of human induced pluripotent stem cells are shaped by the reprogramming route.

High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.

An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.

Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.

A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer’s disease or amyotrophic lateral sclerosis..