Volume 1 Issue 10 October 2017

Volume 1 Issue 10

Phenotyping tumour heterogeneity This issue highlights the analysis of tumour-heterogeneity patterns to stratify patient prognosis, growing paediatric implants, and advances in gastrointestinal motility sensing and in the discovery of peptides that rescue the misfolding of disease-associated proteins.

The cover illustrates patterns of vascular heterogeneity in cleared solid tumours identified through light-sheet microscopy (Article).

Image from Nobuyuki Tanaka and Per Uhlén.

Editorial

  • Editorial |

    When reading or writing about biomedical findings, be mindful of factual accuracy and wary of unapparent caveats.

News and Views

  • News and Views |

    Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

    • Boyan K. Garvalov
    •  & Ali Ertürk
  • News and Views |

    Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

    • Ghazaleh Haghiashtiani
    •  & Michael C. McAlpine
  • News and Views |

    Devices made with resorbable polymers and braided materials can accommodate tissue growth in long-bone and heart-valve animal models.

    • Scott J. Hollister
  • News and Views |

    The genetic, epigenetic and transcriptomic profiles of human-induced pluripotent stem cells are shaped by the reprogramming route.

    • Thomas F. Allison
    •  & William E. Lowry
  • News and Views |

    High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

    • Tobias Langenberg
    • , Joost Schymkowitz
    •  & Frederic Rousseau

Reviews

  • Perspective |

    This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

    • Sine Reker Hadrup
    •  & Evan W. Newell

Research

  • Article |

    A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Raju Tomer
    • , Cecilia Sahlgren
    • , Pauliina Kronqvist
    • , Dagmara Kaczynska
    • , Lauri Louhivuori
    • , Lorand Kis
    • , Claes Lindh
    • , Przemysław Mitura
    • , Andrzej Stepulak
    • , Sara Corvigno
    • , Johan Hartman
    • , Patrick Micke
    • , Artur Mezheyeuski
    • , Carina Strell
    • , Joseph W. Carlson
    • , Carlos Fernández Moro
    • , Hanna Dahlstrand
    • , Arne Östman
    • , Kazuhiro Matsumoto
    • , Peter Wiklund
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Karl Deisseroth
    •  & Per Uhlén
  • Article |

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso
  • Article |

    An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.

    • Eric N. Feins
    • , Yuhan Lee
    • , Eoin D. O’Cearbhaill
    • , Nikolay V. Vasilyev
    • , Shogo Shimada
    • , Ingeborg Friehs
    • , Douglas Perrin
    • , Peter E. Hammer
    • , Haruo Yamauchi
    • , Gerald Marx
    • , Andrew Gosline
    • , Veaceslav Arabagi
    • , Jeffrey M. Karp
    •  & Pedro J. del Nido
  • Article |

    Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.

    • Jared M. Churko
    • , Jaecheol Lee
    • , Mohamed Ameen
    • , Mingxia Gu
    • , Meenakshi Venkatasubramanian
    • , Sebastian Diecke
    • , Karim Sallam
    • , Hogune Im
    • , Gavin Wang
    • , Joseph D. Gold
    • , Nathan Salomonis
    • , Michael P. Snyder
    •  & Joseph C. Wu
  • Article |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas