Latest Research

  • Article |

    Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.

    • Nicholas L. Opie
    • , Sam E. John
    • , Gil S. Rind
    • , Stephen M. Ronayne
    • , Yan T. Wong
    • , Giulia Gerboni
    • , Peter E. Yoo
    • , Timothy J. H. Lovell
    • , Theodore C. M. Scordas
    • , Stefan L. Wilson
    • , Anthony Dornom
    • , Thomas Vale
    • , Terence J. O’Brien
    • , David B. Grayden
    • , Clive N. May
    •  & Thomas J. Oxley
  • Article |

    CRISPR–Cas9-mediated genome editing can be activated locally in vivo via an applied magnetic field, after complexation of magnetic nanoparticles with recombinant baculoviral vectors packaging the CRISPR–Cas9 machinery.

    • Haibao Zhu
    • , Linlin Zhang
    • , Sheng Tong
    • , Ciaran M. Lee
    • , Harshavardhan Deshmukh
    •  & Gang Bao
  • Article |

    DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.

    • Dawei Jiang
    • , Zhilei Ge
    • , Hyung-Jun Im
    • , Christopher G. England
    • , Dalong Ni
    • , Junjun Hou
    • , Luhao Zhang
    • , Christopher J. Kutyreff
    • , Yongjun Yan
    • , Yan Liu
    • , Steve Y. Cho
    • , Jonathan W. Engle
    • , Jiye Shi
    • , Peng Huang
    • , Chunhai Fan
    • , Hao Yan
    •  & Weibo Cai
  • Article |

    The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.

    • Quanyin Hu
    • , Wujin Sun
    • , Jinqiang Wang
    • , Huitong Ruan
    • , Xudong Zhang
    • , Yanqi Ye
    • , Song Shen
    • , Chao Wang
    • , Weiyue Lu
    • , Ke Cheng
    • , Gianpietro Dotti
    • , Joshua F. Zeidner
    • , Jun Wang
    •  & Zhen Gu
  • Article |

    A deep-learning algorithm can detect polyps in the colon in real time and with high sensitivity and specificity, according to validation studies with prospectively collected images and videos from colonoscopies performed in 1,138 patients.

    • Pu Wang
    • , Xiao Xiao
    • , Jeremy R. Glissen Brown
    • , Tyler M. Berzin
    • , Mengtian Tu
    • , Fei Xiong
    • , Xiao Hu
    • , Peixi Liu
    • , Yan Song
    • , Di Zhang
    • , Xue Yang
    • , Liangping Li
    • , Jiong He
    • , Xin Yi
    • , Jingjia Liu
    •  & Xiaogang Liu
  • Article |

    The combination of mathematical modelling of tumour tissue, optical imaging of cleared tumours from animal models, and in vivo imaging of vascular perfusion in tumours predicts the tumour uptake and distribution of specific therapeutic agents.

    • Angela d’Esposito
    • , Paul W. Sweeney
    • , Morium Ali
    • , Magdy Saleh
    • , Rajiv Ramasawmy
    • , Thomas A. Roberts
    • , Giulia Agliardi
    • , Adrien Desjardins
    • , Mark F. Lythgoe
    • , R. Barbara Pedley
    • , Rebecca Shipley
    •  & Simon Walker-Samuel
  • Article |

    An alert system based on machine learning and trained on surgical data from electronic medical records helps anaesthesiologists prevent hypoxaemia during surgery by providing interpretable real-time predictions.

    • Scott M. Lundberg
    • , Bala Nair
    • , Monica S. Vavilala
    • , Mayumi Horibe
    • , Michael J. Eisses
    • , Trevor Adams
    • , David E. Liston
    • , Daniel King-Wai Low
    • , Shu-Fang Newman
    • , Jerry Kim
    •  & Su-In Lee
  • Review Article |

    This Review summarizes the medical applications of artificial intelligence, and its economic, legal and social implications for healthcare.

    • Kun-Hsing Yu
    • , Andrew L. Beam
    •  & Isaac S. Kohane
  • Article |

    Bioresorbable pressure sensors with significantly improved operational lifetimes, as exemplified via the monitoring of intracranial pressure in rats for over 25 days, can be similarly accurate to analogous non-resorbable clinical devices.

    • Jiho Shin
    • , Ying Yan
    • , Wubin Bai
    • , Yeguang Xue
    • , Paul Gamble
    • , Limei Tian
    • , Irawati Kandela
    • , Chad R. Haney
    • , William Spees
    • , Yechan Lee
    • , Minseok Choi
    • , Jonathan Ko
    • , Hangyu Ryu
    • , Jan-Kai Chang
    • , Maryam Pezhouh
    • , Seung-Kyun Kang
    • , Sang Min Won
    • , Ki Jun Yu
    • , Jianing Zhao
    • , Yoon Kyeung Lee
    • , Matthew R. MacEwan
    • , Sheng-Kwei Song
    • , Yonggang Huang
    • , Wilson Z. Ray
    •  & John A. Rogers
  • Article |

    The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.

    • Mohammad Ariful Islam
    • , Yingjie Xu
    • , Wei Tao
    • , Jessalyn M. Ubellacker
    • , Michael Lim
    • , Daniel Aum
    • , Gha Young Lee
    • , Kun Zhou
    • , Harshal Zope
    • , Mikyung Yu
    • , Wuji Cao
    • , James Trevor Oswald
    • , Meshkat Dinarvand
    • , Morteza Mahmoudi
    • , Robert Langer
    • , Philip W. Kantoff
    • , Omid C. Farokhzad
    • , Bruce R. Zetter
    •  & Jinjun Shi
  • Article |

    An assay that uses machine-learning algorithms on phenotypic-biomarker data from live primary cells predicts post-surgical adverse pathology in prostate-cancer and breast cancer tissue samples from patients.

    • Michael S. Manak
    • , Jonathan S. Varsanik
    • , Brad J. Hogan
    • , Matt J. Whitfield
    • , Wendell R. Su
    • , Nikhil Joshi
    • , Nicolai Steinke
    • , Andrew Min
    • , Delaney Berger
    • , Robert J. Saphirstein
    • , Gauri Dixit
    • , Thiagarajan Meyyappan
    • , Hui-May Chu
    • , Kevin B. Knopf
    • , David M. Albala
    • , Grannum R. Sant
    •  & Ashok C. Chander
  • Article |

    A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.

    • Ryan Snodgrass
    • , Andrea Gardner
    • , Aggrey Semeere
    • , Varun Lingaiah Kopparthy
    • , Jens Duru
    • , Toby Maurer
    • , Jeffrey Martin
    • , Ethel Cesarman
    •  & David Erickson
  • Perspective |

    This Perspective describes the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outlines opportunities for their use in improving the care of sepsis patients.

    • B. Reddy Jr
    • , U. Hassan
    • , C. Seymour
    • , D. C. Angus
    • , T. S. Isbell
    • , K. White
    • , W. Weir
    • , L. Yeh
    • , A. Vincent
    •  & R. Bashir
  • Article |

    An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

    • Chonghe Wang
    • , Xiaoshi Li
    • , Hongjie Hu
    • , Lin Zhang
    • , Zhenlong Huang
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Zhenan Yin
    • , Brady Huang
    • , Hua Gong
    • , Shubha Bhaskaran
    • , Yue Gu
    • , Mitsutoshi Makihata
    • , Yuxuan Guo
    • , Yusheng Lei
    • , Yimu Chen
    • , Chunfeng Wang
    • , Yang Li
    • , Tianjiao Zhang
    • , Zeyu Chen
    • , Albert P. Pisano
    • , Liangfang Zhang
    • , Qifa Zhou
    •  & Sheng Xu
  • Article |

    Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.

    • Zhen Ma
    • , Nathaniel Huebsch
    • , Sangmo Koo
    • , Mohammad A. Mandegar
    • , Brian Siemons
    • , Steven Boggess
    • , Bruce R. Conklin
    • , Costas P. Grigoropoulos
    •  & Kevin E. Healy
  • Publisher Correction |

    • Matthew R. Golder
    • , Jenny Liu
    • , Jannik N. Andersen
    • , Michail V. Shipitsin
    • , Farrukh Vohidov
    • , Hung V.-T. Nguyen
    • , Deborah C. Ehrlich
    • , Sung Jin Huh
    • , Bhavatarini Vangamudi
    • , Kyriakos D. Economides
    • , Allison M. Neenan
    • , James C. Ackley
    • , Joelle Baddour
    • , Sattanathan Paramasivan
    • , Samantha W. Brady
    • , Eric J. Held
    • , Lawrence A. Reiter
    • , Jennifer K. Saucier-Sawyer
    • , Paul W. Kopesky
    • , Donald E. Chickering
    • , Peter Blume-Jensen
    •  & Jeremiah A. Johnson
  • Article |

    A personalized virtual-heart model that determines optimal radio-frequency ablation targets for infarct-related tachycardia is validated in retrospective large-animal and patient studies, and in a prospective study in patients.

    • Adityo Prakosa
    • , Hermenegild J. Arevalo
    • , Dongdong Deng
    • , Patrick M. Boyle
    • , Plamen P. Nikolov
    • , Hiroshi Ashikaga
    • , Joshua J. E. Blauer
    • , Elyar Ghafoori
    • , Carolyn J. Park
    • , Robert C. Blake III
    • , Frederick T. Han
    • , Rob S. MacLeod
    • , Henry R. Halperin
    • , David J. Callans
    • , Ravi Ranjan
    • , Jonathan Chrispin
    • , Saman Nazarian
    •  & Natalia A. Trayanova
  • Article |

    Macromolecular telmisartan prodrugs optimized for preferential release in fibrotic liver tissue reduce liver fibrosis in mouse models, and are retained and well tolerated in the liver tissue of rats and dogs.

    • Matthew R. Golder
    • , Jenny Liu
    • , Jannik N. Andersen
    • , Michail V. Shipitsin
    • , Farrukh Vohidov
    • , Hung V.-T. Nguyen
    • , Deborah C. Ehrlich
    • , Sung Jin Huh
    • , Bhavatarini Vangamudi
    • , Kyriakos D. Economides
    • , Allison M. Neenan
    • , James C. Ackley
    • , Joelle Baddour
    • , Sattanathan Paramasivan
    • , Samantha W. Brady
    • , Eric J. Held
    • , Lawrence A. Reiter
    • , Jennifer K. Saucier-Sawyer
    • , Paul W. Kopesky
    • , Donald E. Chickering
    • , Peter Blume-Jensen
    •  & Jeremiah A. Johnson
  • Article |

    Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.

    • Matthew A. Bochenek
    • , Omid Veiseh
    • , Arturo J. Vegas
    • , James J. McGarrigle
    • , Meirigeng Qi
    • , Enza Marchese
    • , Mustafa Omami
    • , Joshua C. Doloff
    • , Joshua Mendoza-Elias
    • , Mohammad Nourmohammadzadeh
    • , Arshad Khan
    • , Chun-Chieh Yeh
    • , Yuan Xing
    • , Douglas Isa
    • , Sofia Ghani
    • , Jie Li
    • , Casey Landry
    • , Andrew R. Bader
    • , Karsten Olejnik
    • , Michael Chen
    • , Jennifer Hollister-Lock
    • , Yong Wang
    • , Dale L. Greiner
    • , Gordon C. Weir
    • , Berit Løkensgard Strand
    • , Anne Mari A. Rokstad
    • , Igor Lacik
    • , Robert Langer
    • , Daniel G. Anderson
    •  & Jose Oberholzer
  • Article |

    Coating the sensor in continuous glucose monitors with a zwitterionic polymer significantly reduces signal noise and the need for frequent device recalibration.

    • Xi Xie
    • , Joshua C. Doloff
    • , Volkan Yesilyurt
    • , Atieh Sadraei
    • , James J. McGarrigle
    • , Mustafa Omami
    • , Omid Veiseh
    • , Shady Farah
    • , Douglas Isa
    • , Sofia Ghani
    • , Ira Joshi
    • , Arturo Vegas
    • , Jie Li
    • , Weiheng Wang
    • , Andrew Bader
    • , Hok Hei Tam
    • , Jun Tao
    • , Hui-jiuan Chen
    • , Boru Yang
    • , Katrina Ann Williamson
    • , Jose Oberholzer
    • , Robert Langer
    •  & Daniel G. Anderson
  • Author Correction |

    • Marnix Lameijer
    • , Tina Binderup
    • , Mandy M. T. van Leent
    • , Max L. Senders
    • , Francois Fay
    • , Joost Malkus
    • , Brenda L. Sanchez-Gaytan
    • , Abraham J. P. Teunissen
    • , Nicolas Karakatsanis
    • , Philip Robson
    • , Xianxiao Zhou
    • , Yuxiang Ye
    • , Gregory Wojtkiewicz
    • , Jun Tang
    • , Tom T. P. Seijkens
    • , Jeffrey Kroon
    • , Erik S. G. Stroes
    • , Andreas Kjaer
    • , Jordi Ochando
    • , Thomas Reiner
    • , Carlos Pérez-Medina
    • , Claudia Calcagno
    • , Edward A. Fisher
    • , Bin Zhang
    • , Ryan E. Temel
    • , Filip K. Swirski
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    • , Esther Lutgens
    • , Willem J. M. Mulder
    •  & Raphaël Duivenvoorden
  • Article |

    Scale models of the human left ventricle made of tissue-engineered nanofibrous scaffolds and primary rat cardiomyocytes or human-stem-cell-derived cardiomyocytes enable the study of contractile function and the modelling of structural arrhythmia.

    • Luke A. MacQueen
    • , Sean P. Sheehy
    • , Christophe O. Chantre
    • , John F. Zimmerman
    • , Francesco S. Pasqualini
    • , Xujie Liu
    • , Josue A. Goss
    • , Patrick H. Campbell
    • , Grant M. Gonzalez
    • , Sung-Jin Park
    • , Andrew K. Capulli
    • , John P. Ferrier
    • , T. Fettah Kosar
    • , L. Mahadevan
    • , William T. Pu
    •  & Kevin Kit Parker
  • Article |

    A low-cost point-of-care device that uses contrast-enhanced microholography and deep learning accurately detects aggressive lymphomas in patients referred for aspiration and biopsy of enlarged lymph nodes.

    • Hyungsoon Im
    • , Divya Pathania
    • , Philip J. McFarland
    • , Aliyah R. Sohani
    • , Ismail Degani
    • , Matthew Allen
    • , Benjamin Coble
    • , Aoife Kilcoyne
    • , Seonki Hong
    • , Lucas Rohrer
    • , Jeremy S. Abramson
    • , Scott Dryden-Peterson
    • , Lioubov Fexon
    • , Misha Pivovarov
    • , Bruce Chabner
    • , Hakho Lee
    • , Cesar M. Castro
    •  & Ralph Weissleder
  • Article |

    The combination of systemic immune checkpoint inhibition with local administration of a hydrogel containing the enzyme catalase, a radioisotope and an immunostimulatory agent promotes effective antitumour immune responses in mice models.

    • Yu Chao
    • , Ligeng Xu
    • , Chao Liang
    • , Liangzhu Feng
    • , Jun Xu
    • , Ziliang Dong
    • , Longlong Tian
    • , Xuan Yi
    • , Kai Yang
    •  & Zhuang Liu
  • Article |

    A magnetic wire for the intravascular recovery of labelled circulating tumour cells improves cell capture in anaesthetized pigs by up to two orders of magnitude with respect to a standard blood draw.

    • Ophir Vermesh
    • , Amin Aalipour
    • , T. Jessie Ge
    • , Yamil Saenz
    • , Yue Guo
    • , Israt S. Alam
    • , Seung-min Park
    • , Charlie N. Adelson
    • , Yoshiaki Mitsutake
    • , Jose Vilches-Moure
    • , Elias Godoy
    • , Michael H. Bachmann
    • , Chin Chun Ooi
    • , Jennifer K. Lyons
    • , Kerstin Mueller
    • , Hamed Arami
    • , Alfredo Green
    • , Edward I. Solomon
    • , Shan X. Wang
    •  & Sanjiv S. Gambhir
  • Article |

    Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

    • Yoonhee Jin
    • , Jung Seung Lee
    • , Jin Kim
    • , Sungjin Min
    • , Soohyun Wi
    • , Ji Hea Yu
    • , Gyeong-Eon Chang
    • , Ann-Na Cho
    • , Yeeun Choi
    • , Da-Hee Ahn
    • , Sung-Rae Cho
    • , Eunji Cheong
    • , Yun-Gon Kim
    • , Hyong-Pyo Kim
    • , Yonghwan Kim
    • , Dong Seok Kim
    • , Hyun Woo Kim
    • , Zhejiu Quan
    • , Hoon-Chul Kang
    •  & Seung-Woo Cho
  • Article |

    The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.

    • Jerzy O. Szablowski
    • , Audrey Lee-Gosselin
    • , Brian Lue
    • , Dina Malounda
    •  & Mikhail G. Shapiro
  • Article |

    A portable device enables the automated manufacturing of therapeutic-grade biologics in a few hours and under current good-manufacturing-practice conditions.

    • Rajani Adiga
    • , Mustafa Al-adhami
    • , Abhay Andar
    • , Shayan Borhani
    • , Sheniqua Brown
    • , David Burgenson
    • , Merideth A. Cooper
    • , Sevda Deldari
    • , Douglas D. Frey
    • , Xudong Ge
    • , Hui Guo
    • , Chandrasekhar Gurramkonda
    • , Penny Jensen
    • , Yordan Kostov
    • , William LaCourse
    • , Yang Liu
    • , Antonio Moreira
    • , KarunaSri Mupparapu
    • , Chariz Peñalber-Johnstone
    • , Manohar Pilli
    • , Benjamin Punshon-Smith
    • , Aniruddha Rao
    • , Govind Rao
    • , Priyanka Rauniyar
    • , Sergei Snovida
    • , Kanika Taurani
    • , Dagmawi Tilahun
    • , Leah Tolosa
    • , Michael Tolosa
    • , Kevin Tran
    • , Krishna Vattem
    • , Sudha Veeraraghavan
    • , Brandon Wagner
    • , Joshua Wilhide
    • , David W. Wood
    •  & Adil Zuber
  • Article |

    A supramolecule that inhibits the colony stimulating factor 1 and SIRPα receptors on macrophages significantly enhances antitumour and antimetastatic efficacies in two aggressive animal models of melanoma and breast cancer.

    • Ashish Kulkarni
    • , Vineethkrishna Chandrasekar
    • , Siva Kumar Natarajan
    • , Anujan Ramesh
    • , Prithvi Pandey
    • , Jayashree Nirgud
    • , Harshangda Bhatnagar
    • , Driti Ashok
    • , Amrendra Kumar Ajay
    •  & Shiladitya Sengupta
  • Article |

    Gene editing of a single gene in the brain of an adult mouse model of fragile X syndrome, achieved via the intracranial injection of a nonviral Cas9 delivery vehicle, rescues mice from the exaggerated repetitive behaviours caused by the disease.

    • Bumwhee Lee
    • , Kunwoo Lee
    • , Shree Panda
    • , Rodrigo Gonzales-Rojas
    • , Anthony Chong
    • , Vladislav Bugay
    • , Hyo Min Park
    • , Robert Brenner
    • , Niren Murthy
    •  & Hye Young Lee
  • Article |

    A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.

    • T. L. Edwards
    • , K. Xue
    • , H. C. M. Meenink
    • , M. J. Beelen
    • , G. J. L. Naus
    • , M. P. Simunovic
    • , M. Latasiewicz
    • , A. D. Farmery
    • , M. D. de Smet
    •  & R. E. MacLaren
  • Review Article |

    This Review discusses the manufacturing of cell products for clinically advanced cell therapies, and highlights potential manufacturing bottlenecks and solutions towards the cost-effective commercialization of the therapies.

    • Ayesha Aijaz
    • , Matthew Li
    • , David Smith
    • , Danika Khong
    • , Courtney LeBlon
    • , Owen S. Fenton
    • , Ronke M. Olabisi
    • , Steven Libutti
    • , Jay Tischfield
    • , Marcela V. Maus
    • , Robert Deans
    • , Rita N. Barcia
    • , Daniel G. Anderson
    • , Jerome Ritz
    • , Robert Preti
    •  & Biju Parekkadan
  • Article |

    An epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium provides therapeutic benefits in a rat model of myocardial infarction.

    • William Whyte
    • , Ellen T. Roche
    • , Claudia E. Varela
    • , Keegan Mendez
    • , Shahrin Islam
    • , Hugh O’Neill
    • , Fiona Weafer
    • , Reyhaneh Neghabat Shirazi
    • , James C. Weaver
    • , Nikolay V. Vasilyev
    • , Peter E. McHugh
    • , Bruce Murphy
    • , Garry P. Duffy
    • , Conor J. Walsh
    •  & David J. Mooney
  • Review Article |

    This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.

    • Louai Labanieh
    • , Robbie G. Majzner
    •  & Crystal L. Mackall
  • Article |

    Uniaxial strain provided by compressed nitinol springs incorporated in human intestinal organoids transplanted into the mouse mesentery enhances organoid growth and maturation, and improves the similarity of the organoids to native human intestine.

    • Holly M. Poling
    • , David Wu
    • , Nicole Brown
    • , Michael Baker
    • , Taylor A. Hausfeld
    • , Nhan Huynh
    • , Samuel Chaffron
    • , James C. Y. Dunn
    • , Simon P. Hogan
    • , James M. Wells
    • , Michael A. Helmrath
    •  & Maxime M. Mahe