Latest Research

  • Article |

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso
  • Perspective |

    This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

    • Sine Reker Hadrup
    •  & Evan W. Newell
  • Article |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas
  • Article |

    An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.

    • Eric N. Feins
    • , Yuhan Lee
    • , Eoin D. O’Cearbhaill
    • , Nikolay V. Vasilyev
    • , Shogo Shimada
    • , Ingeborg Friehs
    • , Douglas Perrin
    • , Peter E. Hammer
    • , Haruo Yamauchi
    • , Gerald Marx
    • , Andrew Gosline
    • , Veaceslav Arabagi
    • , Jeffrey M. Karp
    •  & Pedro J. del Nido
  • Article |

    The expression of two specific DNA-repair factors promotes homology-directed repair and enhances the precision of CRISPR–Cas9 gene editing at multiple loci in human cells, including patient-derived induced pluripotent stem cells.

    • Bruna S. Paulsen
    • , Pankaj K. Mandal
    • , Richard L. Frock
    • , Baris Boyraz
    • , Rachita Yadav
    • , Srigokul Upadhyayula
    • , Paula Gutierrez-Martinez
    • , Wataru Ebina
    • , Anders Fasth
    • , Tomas Kirchhausen
    • , Michael E. Talkowski
    • , Suneet Agarwal
    • , Frederick W. Alt
    •  & Derrick J. Rossi
  • Article |

    Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.

    • Jared M. Churko
    • , Jaecheol Lee
    • , Mohamed Ameen
    • , Mingxia Gu
    • , Meenakshi Venkatasubramanian
    • , Sebastian Diecke
    • , Karim Sallam
    • , Hogune Im
    • , Gavin Wang
    • , Joseph D. Gold
    • , Nathan Salomonis
    • , Michael P. Snyder
    •  & Joseph C. Wu
  • Article |

    A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Raju Tomer
    • , Cecilia Sahlgren
    • , Pauliina Kronqvist
    • , Dagmara Kaczynska
    • , Lauri Louhivuori
    • , Lorand Kis
    • , Claes Lindh
    • , Przemysław Mitura
    • , Andrzej Stepulak
    • , Sara Corvigno
    • , Johan Hartman
    • , Patrick Micke
    • , Artur Mezheyeuski
    • , Carina Strell
    • , Joseph W. Carlson
    • , Carlos Fernández Moro
    • , Hanna Dahlstrand
    • , Arne Östman
    • , Kazuhiro Matsumoto
    • , Peter Wiklund
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Karl Deisseroth
    •  & Per Uhlén
  • Article |

    Gold nanoparticles carrying Cas9 ribonucleoprotein and donor DNA, and complexed with endosomal disruptive polymers, correct the DNA mutation that causes Duchenne muscular dystrophy in mice, with minimal off-target effects.

    • Kunwoo Lee
    • , Michael Conboy
    • , Hyo Min Park
    • , Fuguo Jiang
    • , Hyun Jin Kim
    • , Mark A. Dewitt
    • , Vanessa A. Mackley
    • , Kevin Chang
    • , Anirudh Rao
    • , Colin Skinner
    • , Tamanna Shobha
    • , Melod Mehdipour
    • , Hui Liu
    • , Wen-chin Huang
    • , Freeman Lan
    • , Nicolas L. Bray
    • , Song Li
    • , Jacob E. Corn
    • , Kazunori Kataoka
    • , Jennifer A. Doudna
    • , Irina Conboy
    •  & Niren Murthy
  • Review Article |

    This Review discusses imaging approaches that benefit from the combination of signals and modalities to enhance patient diagnosis and the monitoring of therapy.

    • Kathrin Heinzmann
    • , Lukas M. Carter
    • , Jason S. Lewis
    •  & Eric O. Aboagye
  • Article |

    Nanoscale vibrations provided by a bioreactor induce the differentiation of mesenchymal stem cells into mineralized tissue in three dimensions, independently of other environmental factors.

    • Penelope M. Tsimbouri
    • , Peter G. Childs
    • , Gabriel D. Pemberton
    • , Jingli Yang
    • , Vineetha Jayawarna
    • , Wich Orapiriyakul
    • , Karl Burgess
    • , Cristina González-García
    • , Gavin Blackburn
    • , Dilip Thomas
    • , Catalina Vallejo-Giraldo
    • , Manus J. P Biggs
    • , Adam S. G. Curtis
    • , Manuel Salmerón-Sánchez
    • , Stuart Reid
    •  & Matthew J. Dalby
  • Article |

    Ultrasound pulses controlling the release of an anaesthetic encapsulated in liposomes allow for the timing, intensity and duration of sciatic-nerve blocks in rats.

    • Alina Y. Rwei
    • , Juan L. Paris
    • , Bruce Wang
    • , Weiping Wang
    • , Christopher D. Axon
    • , María Vallet-Regí
    • , Robert Langer
    •  & Daniel S. Kohane
  • Article |

    A system consisting of a glass microelectrode and a boron-doped diamond microsensor can simultaneously track, in rat brains and in the guinea pig cochlea, the local real-time kinetics of injected drugs and the resulting electrophysiological activity.

    • Genki Ogata
    • , Yuya Ishii
    • , Kai Asai
    • , Yamato Sano
    • , Fumiaki Nin
    • , Takamasa Yoshida
    • , Taiga Higuchi
    • , Seishiro Sawamura
    • , Takeru Ota
    • , Karin Hori
    • , Kazuya Maeda
    • , Shizuo Komune
    • , Katsumi Doi
    • , Madoka Takai
    • , Ian Findlay
    • , Hiroyuki Kusuhara
    • , Yasuaki Einaga
    •  & Hiroshi Hibino
  • Article |

    Uniform iron oxide nanoparticle clusters are highly biocompatible and can be used as contrast agents for high-resolution magnetic resonance angiography of large animals.

    • Yang Lu
    • , Yun-Jun Xu
    • , Guo-bing Zhang
    • , Daishun Ling
    • , Ming-quan Wang
    • , Yong Zhou
    • , Ya-Dong Wu
    • , Tao Wu
    • , Michael J. Hackett
    • , Byung Hyo Kim
    • , Hogeun Chang
    • , Jonghoon Kim
    • , Xin-Tian Hu
    • , Liang Dong
    • , Nohyun Lee
    • , Fangyuan Li
    • , Jia-Cai He
    • , Li Zhang
    • , Hui-Qin Wen
    • , Bo Yang
    • , Seung Hong Choi
    • , Taeghwan Hyeon
    •  & Duo-Hong Zou
  • Article |

    Polymer–lipid–peptide nanoparticles carrying an antiplatelet antibody and a chemotherapy drug deplete tumour-associated platelets to increase vascular permeability and augment the accumulation of the drug in tumours.

    • Suping Li
    • , Yinlong Zhang
    • , Jing Wang
    • , Ying Zhao
    • , Tianjiao Ji
    • , Xiao Zhao
    • , Yanping Ding
    • , Xiaozheng Zhao
    • , Ruifang Zhao
    • , Feng Li
    • , Xiao Yang
    • , Shaoli Liu
    • , Zhaofei Liu
    • , Jianhao Lai
    • , Andrew K. Whittaker
    • , Gregory J. Anderson
    • , Jingyan Wei
    •  & Guangjun Nie
  • Article |

    An array-based method can identify synthetic hydrogels that outperform Matrigel in screening for vascular-disruptor compounds and in supporting the expansion and pluripotency of human embryonic stem cells.

    • Eric H. Nguyen
    • , William T. Daly
    • , Ngoc Nhi T. Le
    • , Mitra Farnoodian
    • , David G. Belair
    • , Michael P. Schwartz
    • , Connie S. Lebakken
    • , Gene E. Ananiev
    • , Mohammad Ali Saghiri
    • , Thomas B. Knudsen
    • , Nader Sheibani
    •  & William L. Murphy
  • Article |

    The biophysical properties of cells can be used to predict the cellular age of humans with higher accuracy than conventional biomolecular markers.

    • Jude M. Phillip
    • , Pei-Hsun Wu
    • , Daniele M. Gilkes
    • , Wadsworth Williams
    • , Shaun McGovern
    • , Jena Daya
    • , Jonathan Chen
    • , Ivie Aifuwa
    • , Jerry S. H. Lee
    • , Rong Fan
    • , Jeremy Walston
    •  & Denis Wirtz
  • Article |

    Large microscale arrays of zymosan particle clusters enable the characterization of human-neutrophil swarming, including the presence of start and stop signals, and the deficient swarming behaviour of neutrophils from patients following major trauma.

    • Eduardo Reátegui
    • , Fatemeh Jalali
    • , Aimal H. Khankhel
    • , Elisabeth Wong
    • , Hansang Cho
    • , Jarone Lee
    • , Charles N. Serhan
    • , Jesmond Dalli
    • , Hunter Elliott
    •  & Daniel Irimia
  • Article |

    A library of single-strand oligonucleotide probes with a common long-adapter sequence can clone, in a single reaction, thousands of open reading frames spanning 400–5,000 bp, and has been applied to DNA from human stool and microbiome samples.

    • Lorenzo Tosi
    • , Viswanadham Sridhara
    • , Yunlong Yang
    • , Dongli Guan
    • , Polina Shpilker
    • , Nicola Segata
    • , H. Benjamin Larman
    •  & Biju Parekkadan
  • Article |

    A light-sheet microscope images large surgical and biopsy specimens non-destructively over large fields of view in two and three dimensions, with the same level of detail as traditional slide-based histopathology.

    • Adam K. Glaser
    • , Nicholas P. Reder
    • , Ye Chen
    • , Erin F. McCarty
    • , Chengbo Yin
    • , Linpeng Wei
    • , Yu Wang
    • , Lawrence D. True
    •  & Jonathan T. C. Liu