Latest Research

  • Article |

    A compact, self-contained device bearing an array of microneedles collects 100 μl of blood at the push of a button, and is more convenient and less painful than a fingerstick and venepuncture.

    • Timothy M. Blicharz
    • , Ping Gong
    • , Bernard M. Bunner
    • , Larry L. Chu
    • , Kaela M. Leonard
    • , Jessica A. Wakefield
    • , Richard E. Williams
    • , Maisam Dadgar
    • , Carlo A. Tagliabue
    • , Ragheb El Khaja
    • , Stephanie L. Marlin
    • , Ramin Haghgooie
    • , Shawn P. Davis
    • , Donald E. Chickering
    •  & Howard Bernstein
  • Article |

    The slow release of pro-survival peptide analogues crosslinked to an injectable collagen–dendrimer biomaterial significantly prolongs the engraftment and survival of transplanted stem cells in mouse models of ischaemic injury.

    • Andrew S. Lee
    • , Mohammed Inayathullah
    • , Maarten A. Lijkwan
    • , Xin Zhao
    • , Wenchao Sun
    • , Sujin Park
    • , Wan Xing Hong
    • , Mansi B. Parekh
    • , Andrey V. Malkovskiy
    • , Edward Lau
    • , Xulei Qin
    • , Venkata Raveendra Pothineni
    • , Verónica Sanchez-Freire
    • , Wendy Y. Zhang
    • , Nigel G. Kooreman
    • , Antje D. Ebert
    • , Charles K. F. Chan
    • , Patricia K. Nguyen
    • , Jayakumar Rajadas
    •  & Joseph C. Wu
  • Article |

    Cells engineered to produce an analgesic in response to spearmint aroma and implanted in mouse models of chronic pain reduce the pain-associated behaviour after oral intake of spearmint essential oil with no adverse effects.

    • Hui Wang
    • , Mingqi Xie
    • , Ghislaine Charpin-El Hamri
    • , Haifeng Ye
    •  & Martin Fussenegger
  • Article |

    A system that combines positron emission tomography, computed tomography and ultrafast ultrasound allows for simultaneous multi-parametric imaging in animal models.

    • Jean Provost
    • , Anikitos Garofalakis
    • , Joevin Sourdon
    • , Damien Bouda
    • , Béatrice Berthon
    • , Thomas Viel
    • , Mailyn Perez-Liva
    • , Charlotte Lussey-Lepoutre
    • , Judith Favier
    • , Mafalda Correia
    • , Mathieu Pernot
    • , Johanna Chiche
    • , Jacques Pouysségur
    • , Mickael Tanter
    •  & Bertrand Tavitian
  • Review Article |

    This Review discusses technology for the isolation and phenotypic profiling of circulating tumour cells from blood for the identification of those with high metastatic potential as well as requirements for clinical applications of the cells.

    • Mahla Poudineh
    • , Edward H. Sargent
    • , Klaus Pantel
    •  & Shana O. Kelley
  • Article |

    A microtechnology involving force sensors embedded in elastomers for cell culture enables the high-throughput measurement of single-cell force generation from contractile cells in a scalable and highly parallelized manner.

    • Ivan Pushkarsky
    • , Peter Tseng
    • , Dylan Black
    • , Bryan France
    • , Lyndon Warfe
    • , Cynthia J. Koziol-White
    • , William F. Jester Jr
    • , Ryan K. Trinh
    • , Jonathan Lin
    • , Philip O. Scumpia
    • , Sherie L. Morrison
    • , Reynold A. Panettieri Jr
    • , Robert Damoiseaux
    •  & Dino Di Carlo
  • Article |

    Nanoparticles carrying an antibiotic and conjugated with a peptide identified via phage display that binds specifically to Staphylococcus aureus effectively suppress staphylococcal infections in vivo.

    • Sazid Hussain
    • , Jinmyoung Joo
    • , Jinyoung Kang
    • , Byungji Kim
    • , Gary B. Braun
    • , Zhi-Gang She
    • , Dokyoung Kim
    • , Aman P. Mann
    • , Tarmo Mölder
    • , Tambet Teesalu
    • , Santina Carnazza
    • , Salvatore Guglielmino
    • , Michael J. Sailor
    •  & Erkki Ruoslahti
  • Perspective |

    This Perspective argues that a significant number of bone fractures in the elderly are insufficiency fractures caused by cyclic loading from daily activities, which induces fatigue cracking, rather than the result of impacts or trauma.

    • Claire Acevedo
    • , Vincent A. Stadelmann
    • , Dominique P. Pioletti
    • , Tamara Alliston
    •  & Robert O. Ritchie
  • Article |

    Engineered commensal microbes that transform natural compounds present in cruciferous vegetables into an anticancer molecule prevent carcinogenesis and promote the regression of colorectal cancer in mice fed with the microbes and the vegetables.

    • Chun Loong Ho
    • , Hui Qing Tan
    • , Koon Jiew Chua
    • , Aram Kang
    • , Kiat Hon Lim
    • , Khoon Lin Ling
    • , Wen Shan Yew
    • , Yung Seng Lee
    • , Jean Paul Thiery
    •  & Matthew Wook Chang
  • Article |

    A cloud-based machine-learning software that scores individual guide–target pairs and provides an overall summary score for a given guide that outperforms competing algorithms for the prediction of CRISPR–Cas9 off-target effects.

    • Jennifer Listgarten
    • , Michael Weinstein
    • , Benjamin P. Kleinstiver
    • , Alexander A. Sousa
    • , J. Keith Joung
    • , Jake Crawford
    • , Kevin Gao
    • , Luong Hoang
    • , Melih Elibol
    • , John G. Doench
    •  & Nicolo Fusi
  • Article |

    The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.

    • Junnan Tang
    • , Teng Su
    • , Ke Huang
    • , Phuong-Uyen Dinh
    • , Zegen Wang
    • , Adam Vandergriff
    • , Michael T. Hensley
    • , Jhon Cores
    • , Tyler Allen
    • , Taosheng Li
    • , Erin Sproul
    • , Emily Mihalko
    • , Leonard J. Lobo
    • , Laura Ruterbories
    • , Alex Lynch
    • , Ashley Brown
    • , Thomas G. Caranasos
    • , Deliang Shen
    • , George A. Stouffer
    • , Zhen Gu
    • , Jinying Zhang
    •  & Ke Cheng
  • Publisher Correction |

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas
  • Publisher Correction |

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Raju Tomer
    • , Cecilia Sahlgren
    • , Pauliina Kronqvist
    • , Dagmara Kaczynska
    • , Lauri Louhivuori
    • , Lorand Kis
    • , Claes Lindh
    • , Przemysław Mitura
    • , Andrzej Stepulak
    • , Sara Corvigno
    • , Johan Hartman
    • , Patrick Micke
    • , Artur Mezheyeuski
    • , Carina Strell
    • , Joseph W. Carlson
    • , Carlos Fernández Moro
    • , Hanna Dahlstrand
    • , Arne Östman
    • , Kazuhiro Matsumoto
    • , Peter Wiklund
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Karl Deisseroth
    •  & Per Uhlén
  • Article |

    A patient-specific soft cardiovascular occluder made via three-dimensional printing and static moulding of an inflatable polymer balloon on the basis of data derived from computed tomography scans of a large animal is implanted in the same animal.

    • Sanlin S. Robinson
    • , Seyedhamidreza Alaie
    • , Hannah Sidoti
    • , Jordyn Auge
    • , Lohendran Baskaran
    • , Kenneth Avilés-Fernández
    • , Samantha D. Hollenberg
    • , Robert F. Shepherd
    • , James K. Min
    • , Simon N. Dunham
    •  & Bobak Mosadegh
  • Article |

    Rare-earth-doped albumin-encapsulated nanoparticles emitting short-wave infrared light enable whole-body real-time tracking of metastatic lesions in multiple organs in mice.

    • Harini Kantamneni
    • , Margot Zevon
    • , Michael J. Donzanti
    • , Xinyu Zhao
    • , Yang Sheng
    • , Shravani R. Barkund
    • , Lucas H. McCabe
    • , Whitney Banach-Petrosky
    • , Laura M. Higgins
    • , Shridar Ganesan
    • , Richard E. Riman
    • , Charles M. Roth
    • , Mei-Chee Tan
    • , Mark C. Pierce
    • , Vidya Ganapathy
    •  & Prabhas V. Moghe
  • Article |

    A biodegradable probe made of dextran and a urea-based targeting ligand for prostate-specific membrane antigen enables targeted magnetic resonance imaging of tumours expressing the receptor in a xenograft mouse model of prostate cancer.

    • Guanshu Liu
    • , Sangeeta Ray Banerjee
    • , Xing Yang
    • , Nirbhay Yadav
    • , Ala Lisok
    • , Anna Jablonska
    • , Jiadi Xu
    • , Yuguo Li
    • , Martin G. Pomper
    •  & Peter van Zijl
  • Article |

    A computational approach that uses the statistics of movement to find a mapping between neural activity and motor variables decodes the intended movements of monkeys with performance comparable to that of supervised methods.

    • Eva L. Dyer
    • , Mohammad Gheshlaghi Azar
    • , Matthew G. Perich
    • , Hugo L. Fernandes
    • , Stephanie Naufel
    • , Lee E. Miller
    •  & Konrad P. Körding
  • Article |

    A slide-free, inexpensive and non-destructive microscopy technique rapidly provides high-resolution histology images that resemble those obtained from conventional haematoxylin-and-eosin-stained specimens.

    • Farzad Fereidouni
    • , Zachary T. Harmany
    • , Miao Tian
    • , Austin Todd
    • , John A. Kintner
    • , John D. McPherson
    • , Alexander D. Borowsky
    • , John Bishop
    • , Mirna Lechpammer
    • , Stavros G. Demos
    •  & Richard Levenson
  • Article |

    An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in mice after myocardial infarction.

    • Leo L. Wang
    • , Ying Liu
    • , Jennifer J. Chung
    • , Tao Wang
    • , Ann C. Gaffey
    • , Minmin Lu
    • , Christina A. Cavanaugh
    • , Su Zhou
    • , Rahul Kanade
    • , Pavan Atluri
    • , Edward E. Morrisey
    •  & Jason A. Burdick