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Machine-learning algorithms trained with retinal fundus images, with
subject metadata or with both data types, predict haemoglobin concentration with
mean absolute errors lower than 0.75 g dl–1 and anaemia
with areas under the curve in the range of 0.74–0.89.
Structural and functional analyses of the remodelling of intact lymphatic vasculature after the ligation of a hind-limb lymphatic vessel in sheep reveal the adaptations to the changes in fluid load that occur after lymphatic injury.
An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients.
A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.
Micropatterned nitinol (a nickel titanium alloy) thin films loaded with human CAR-T cells and implanted into tumours foster the expansion of the cells and extend animal survival in mouse models of human tumours.
A near-infrared-light-sensitive photovoltaic subretinal prosthesis triggers behavioural responses in awake macaques, even two years after device implantation.
The local delivery of a calcium channel blocker and a Rho-kinase inhibitor, determined by screening for small molecules that cause ureteral relaxation, significantly reduce ureteral contraction in pigs.
Pink-beam synchrotron X-ray tomography combined with mechanical loading at nanometric precision enables the in situ imaging of intact untreated joints, resolving strains at sub-100 nm resolution.
A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.
The serial assessment of the functional parameters of leukocytes isolated via an inertial microfluidic system from 50 μl of peripheral blood from sepsis patients provides significantly more prognostic information than leukocyte counting.
Anionic nanoparticles increase intestinal permeability and enable the oral delivery of proteins, as shown with the delivery of insulin in healthy, hyperglycaemic, and diabetic mice.
A computational approach for the design of self-assembling antibody–drug conjugates via affinity ligands for specific conserved amino acid residues in antibodies yields homogenous and stable antibody–drug conjugates that form in less than 8 min.
Attaching a syndecan-binding domain to vascular endothelial and platelet-derived growth factor variants enhances their binding to syndecans and triggers tonic signalling for enhanced bone regeneration and wound repair in mice.
Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.
A deep-learning model trained to map 2D projection views of a patient to the corresponding 3D anatomy can subsequently generate volumetric tomographic X-ray images of the patient from a single projection view.
Downregulation of the transcription factor KLF4 in keratinocyte precursors improves the proliferation and maintenance of immature keratinocytes in vitro and the generation of epidermis in vivo.
The analysis of behavioural patterns from standardized video recordings of infants with varying degrees of visual impairment enables, via deep learning, classification of the infants by visual-impairment severity and by ophthalmological condition.
Decellularized whole porcine livers revascularized with human endothelial cells and implanted heterotopically into immunosuppressed pigs whose spleens had been removed can sustain perfusion for up to 15 days.
The loss of residual strains in the intervertebral disc alters the microenvironment and instigates aberrant tissue remodelling and the adoption of atypical cellular phenotypes, promoting disease progression.
An electronic interface with 4,096 electrodes can intracellularly record postsynaptic potentials and action potentials from thousands of connected mammalian neurons in vitro.