News & Comment

  • News & Views |

    Plasmids coding for a toxin gene that is only expressed in the presence of a virulence-associated transcription factor lead to the killing of only the virulent form of the bacterium Vibrio cholerae in a mixed bacterial population.

    • Richard Novick
  • News & Views |

    An electrical biosensor that relies on the binding of target nucleic acid sequences to Cas9 immobilized on a graphene field-effect transistor enables the rapid detection of mutations in purified samples without the need for nucleic acid amplification.

    • Richard Bruch
    • , Gerald A. Urban
    •  & Can Dincer
  • News & Views |

    Histologically stained slides can be generated from unlabelled autofluorescence images of tissue samples via deep learning.

    • Spyridon Bakas
    •  & Michael D. Feldman
  • News & Views |

    A microfluidic assay that quantifies the abundance and degree of proliferation of migratory cells predicts the metastatic potential of breast-cancer cell lines and patient-derived cells.

    • Zhengpeng Wan
    •  & Roger D. Kamm
  • News & Views |

    Early-stage ovarian cancer can be detected in few-microlitre plasma samples via a microfluidic chip, patterned with nanoporous herringbone structures so as to enhance the capture of extracellular vesicles from the samples.

    • Yuan Wan
    •  & Si-Yang Zheng
  • Comment |

    The development of implantable electrode arrays that broadly and seamlessly integrate with brain tissue will require innovation that responsibly considers clinically relevant neuroethical concerns.

    • Laura Cabrera
    • , Charles Sadle
    •  & Erin Purcell
  • News & Views |

    The oxygen consumption rates of single tumour cells can be measured via photoacoustic microscopy, by leveraging haemoglobin as both an oxygen supplier and an oxygen sensor.

    • Alex J. Walsh
    • , Joe T. Sharick
    •  & Melissa C. Skala
  • News & Views |

    The biodistribution of the components of a messenger RNA vaccine following its administration in non-human primates can be non-invasively monitored by labelling the vaccine with a dual radionuclide–near-infrared probe.

    • Sebastian Ols
    •  & Karin Loré
  • Editorial |

    The development of imaging technology for the quantification of optical biomarkers of pathological processes should involve the validation of the biomarkers’ biological accuracy.

  • News & Views |

    High-speed optoacoustic tomography can monitor the neural activity of a whole mouse brain, by using a genetically encoded calcium sensor originally developed for fluorescence microscopy.

    • Alessio Andreoni
    •  & Lin Tian
  • News & Views |

    Inactivation of the major histocompatibility complex and overexpression of the transmembrane protein CD47 renders induced pluripotent stem cells invisible to the immune system of the host.

    • Tom Shani
    •  & Jacob H. Hanna
  • News & Views |

    Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.

    • Anita S. Chong
  • News & Views |

    Depletion of cells expressing the cell-membrane protein programmed cell-death protein-1 using an antibody-based toxin delays the onset of disease in a mouse model of diabetes and reverses paralysis in mice with experimental autoimmune encephalomyelitis, without compromising physiological immunity.

    • Zhirui Wang
    •  & Christene A. Huang
  • News & Views |

    High-throughput nanoparticle synthesis combined with machine learning speeds up the exploration of structure–activity relationships for nanomedicines, as shown for spherical nucleic acids functioning as cancer-vaccine candidates.

    • Yijing Liu
    •  & Xiaoyuan Chen
  • News & Views |

    An antibody-modified nanoparticle encapsulating a pH-sensitive taxane prodrug, and targeting an overexpressed receptor in tumours, improves the tolerability and anticancer efficacy of the active drug in multiple animal models.

    • Ernesto Moles
    •  & Maria Kavallaris
  • News & Views |

    Enhanced lysosomal degradation of the transmembrane protein programmed cell-death protein-1 ligand in tumour cells, enabled by blocking the protein’s post-translational lipid modification, promotes T-cell-mediated suppression of tumour growth in mice.

    • Stephane Lefrancois
  • News & Views |

    A bioprinted glioblastoma-on-a-chip model enables the evaluation of treatment responses for individual patients whose brain tumours resist standard chemoradiotherapy.

    • Natividad Gomez-Roman
    •  & Anthony J. Chalmers
  • Editorial |

    Peer review relies on organized scepticism and implicit trust. A healthy balance of both qualities should also prevail when peer review fails.

  • News & Views |

    Large-area electrode arrays for epidermal electrophysiology offer new possibilities for the control of prosthetic devices and the monitoring of brain function.

    • Damiano G. Barone
    •  & George G. Malliaras
  • News & Views |

    Accurate and explainable detection, via deep learning, of acute intracranial haemorrhage from computed tomography images of the head is achievable with small amounts of data for model training.

    • Michael C. Muelly
    •  & Lily Peng
  • News & Views |

    A patch that deposits an array of microneedle tips under the top layer of the skin enables weeks-long delivery of a contraceptive in rats.

    • Ryan F. Donnelly
    •  & Eneko Larraňeta
  • News & Views |

    An inexpensive assay that uses thermophoresis to concentrate cancer extracellular vesicles bound to aptamers specific for target proteins on the vesicles’ surface, can classify cancer patients according to cancer type and stage.

    • Hakho Lee
    •  & Cesar M. Castro
  • News & Views |

    By compressing blood vessels and neurons, globular tumours in the brain can cause neuronal damage, which can be partially reversed by relieving the stress via tumour removal or by administering lithium.

    • Paul A. Janmey
    •  & Katarzyna Pogoda
  • News & Views |

    A computationally designed small molecule inhibits the replication of prion-protein aggregates and ameliorates neurological symptoms in mouse and non-human-primate models of transmissible spongiform encephalopathy.

    • Emiliano Biasini
  • News & Views |

    Magnetic nanoparticles complexed with recombinant baculoviral vectors containing the CRISPR–Cas9 machinery enable the local magnetic activation of genome editing.

    • Mu-Nung Hsu
    •  & Yu-Chen Hu
  • Editorial |

    The simplicity and powerful capabilities of CRISPR have led to an explosion of genome-editing applications. Their continued development should be nurtured by scientific and legal environments that discourage and penalize irresponsible uses of the technology.

  • News & Views |

    The stiffness associated with cardiac fibrosis activates the expression of a common genetic polymorphism associated with cardiac pathology.

    • Todd Joseph Herron
  • News & Views |

    Graftable skin expressing an enzyme that metabolizes cocaine may offer a new strategy to treat cocaine addiction.

    • Xin-an Liu
    •  & Paul J. Kenny
  • News & Views |

    Human cardiomyocytes and mice edited to harbour gene variants found in patients with dilated cardiomyopathy reveal combinatorial genetic interactions that contribute to the complex genetic heritability of the disease.

    • Ning Ma
    • , Sophia L. Zhang
    •  & Joseph C. Wu
  • News & Views |

    A microdevice implanted in deep tissue can measure electromagnetic signals and convert them to magnetic-resonance-imaging-detectable signals.

    • Zhijie Zhu
    • , Ghazaleh Haghiashtiani
    •  & Michael C. McAlpine
  • News & Views |

    A miniaturized 128-electrode brain implant enables wireless closed-loop neuromodulation with artefact cancellation in a non-human primate.

    • Chia-Han Chiang
    •  & Jonathan Viventi
  • Editorial |

    Implantable sensors and electrodes that take advantage of new materials, device designs and fabrication strategies enable new and improved biomedical applications.

  • News & Views |

    A wirelessly powered optoelectronic device that adheres to internal tissue facilitates the application of low-dose, long-term photodynamic cancer therapy.

    • Youngsik Lee
    •  & Dae-Hyeong Kim
  • News & Views |

    A tissue-engineered scale model of the human ventricle made of nanofibrous scaffolds and human-stem-cell-derived cardiomyocytes enables the modelling of arrhythmia.

    • Wolfram-Hubertus Zimmermann
  • News & Views |

    A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.

    • Irina Matei
    • , Sham Rampersaud
    •  & David Lyden
  • News & Views |

    Coating continuous glucose-monitoring sensors with zwitterionic polymer reduces early inflammatory responses and signal noise after sensor implantation in live animals, and improves the performance of the sensors without the need for additional recalibration.

    • Ershuai Zhang
    •  & Zhiqiang Cao
  • Editorial |

    Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease.

  • News & Views |

    Minimally invasive intravascular electrodes chronically implanted via the superior sagittal sinus can stimulate the motor cortex of sheep, and elicit muscular activity.

    • Robert S. Fisher
  • News & Views |

    Co-cultures of muscle cells and optogenetic motor neurons derived from patient-specific human stem cells make a physiologically relevant model of amyotrophic lateral sclerosis.

    • Ariel Ionescu
    •  & Eran Perlson
  • News & Views |

    A machine-learning algorithm reliably predicts Cas9-edited genotypes arising from the repair of DNA double-strand breaks in mouse cells and human cells.

    • Sangsu Bae
    •  & Jin-Soo Kim
  • News & Views |

    Transplanting allogeneic pancreatic islets intraperitoneally by first encapsulating the islets within an alginate-based formulation results in reduced fibrosis and capsule clumping, and thus in improved islet survival.

    • Alexander E. Vlahos
    •  & Michael V. Sefton
  • News & Views |

    The coupling of blood platelets bearing anti-programmed cell death protein 1 antibodies to haematopoietic stem cells enables delivery of checkpoint-blockade therapy to bone marrow to promote T-cell-mediated control of leukaemia in mice.

    • Martina Seiffert
  • News & Views |

    Widespread editing of the mutated DMD gene by CRISPR–Cas9, systemically delivered via an adeno-associated virus, restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

    • Dongsheng Duan
  • News & Views |

    A computational model of the heart that finds the optimal ablation sites to treat infarct-related ventricular tachycardia eliminates the need for invasive electrical mapping.

    • Michael S. Sacks