Cancer diagnostics

Editorial

Editorial | 12 April 2017

Brighter cancer probes

The early detection of cancer demands translatable light-emitting or light-collecting probes with unprecedented levels of sensitivity and specificity.

Comment

Comment | 12 April 2017

Clinical prospects of liquid biopsies​

The clinical utility of diagnostic markers extracted from liquid biopsies from cancer patients is hampered by knowledge gaps in biological understanding but can be aided by technological developments.

Catherine Alix-Panabières & Klaus Pantel

News & Views

News and Views | 12 April 2017

Cancer diagnostics: Light scattering by pancreatic cysts

Pancreatic cysts can be detected via the optical-scatter patterns of these submicroscopic sack-like pockets of tissue.

Brian W. Pogue & Kenneth K. Wang

News and Views | 12 April 2017

Cancer diagnostics: Extracting extraceullar vesicles

Two approaches for quantifying extracellular vesicles in blood samples facilitate the search for highly specific cancer biomarkers.

Ting-Wen Lo & Sunitha Nagrath

News and Views | 12 April 2017

Optical diagnostics: Nanosensors for liquid biopsies​

Carbon nanotubes enable the optical detection of nucleic acids in biofluids.

Irene de Lázaro & Kostas Kostarelos

News and Views | 12 April 2017

Cancer diagnostics: On-target probes for early detection

Optical probes that are activated only in the tumour microenvironment dramatically improve the sensitivity of cancer detection.

Sharon S. Hori, Willemieke S. Tummers & Sanjiv S. Gambhir

News and Views | 12 April 2017

Cancer: Seeing the ebb of a tumour virus

A fluorescent peptide that blocks the dimerization of a protein associated with the Epstein–Barr virus enables the imaging and growth inhibition of tumours attributed to the pathogen.

John G. Kosowicz, Jaeyeun Lee & Richard F. Ambinder

News and Views | 12 April 2017

Optical imaging: Resolutely deep and fast

Functionalized quantum dots emitting short-wavelength infrared light enable small-animal imaging with deep penetration, high spatial resolution and fast acquisition speeds.

Eva M. Sevick-Muraca

Articles

Article | 06 February 2017

Nanoplasmonic quantification of tumour-derived extracellular vesicles in plasma microsamples for diagnosis and treatment monitoring

A rapid, inexpensive and ultrasensitive assay that uses antibody-conjugated nanoparticle probes on the surface of a sensor chip quantifies tumour-derived extracellular vesicles to detect pancreatic cancer from 1 μl of blood plasma.

Kai Liang, Fei Liu […] & Ye Hu

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Article | 13 March 2017

Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy

An optical spectroscopic technique and fibre-optic probe, compatible with clinical ultrasound-guided fine-needle aspiration, accurately distinguishes cancerous, precancerous and benign pancreatic cysts.

Lei Zhang, Douglas K. Pleskow […] & Lev T. Perelman

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Article | 13 March 2017

A carbon nanotube reporter of microRNA hybridization events in vivo

A carbon nanotube sensor enables real-time optical quantification of hybridization events of microRNA and other oligonucleotides in vivo and in whole urine and serum.

Jackson D. Harvey, Prakrit V. Jena […] & Daniel A. Heller

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Article | 13 March 2017

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus

A peptide-based fluorescent inhibitor of the dimerization of an oncoprotein of the Epstein–Barr virus blocks the proliferation of tumours associated with the virus in mice.

Lijun Jiang, Rongfeng Lan […] & Ka-Leung Wong

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Article | 10 April 2017

Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes

Nanoscale extracellular vesicles can be efficiently isolated in about 15 minutes, for downstream analyses of nucleic acids and proteins, via spontaneous labelling through a lipid nanoprobe and subsequent magnetic capture of the labelled vesicles.

Yuan Wan, Gong Cheng […] & Si-Yang Zheng

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Article | 10 April 2017

Ultrasensitive tumour-penetrating nanosensors of protease activity

An optimized nanosensor with tumour-penetrating ligands and with peptide substrates that lead to maximal tumour-specific protease cleavage detects sub-5 mm lesions in human epithelial tumour xenografts and in an orthotopic model of ovarian cancer.

Ester J. Kwon, Jaideep S. Dudani & Sangeeta N. Bhatia

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Article | 10 April 2017

Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia

A macromolecular near-infrared probe that successively responds to tumour acidity and hypoxia while amplifying detection sensitivity via signal propagation detects metastatic tumour nodules as small as 1 mm in mice.

Xianchuang Zheng, Hui Mao […] & Xiqun Jiang

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Article | 10 April 2017

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Functionalized InAs quantum dots emitting in the short-wavelength infrared spectral region enable functional biomedical imaging at unprecedentedly high spatial resolution, deep penetration and fast acquisition speeds.

Oliver T. Bruns, Thomas S. Bischof […] & Moungi G. Bawendi