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A bead-based fluorescence sandwich immunoassay implemented in a custom microfluidic chip can continuously measure glucose and insulin with picomolar sensitivity and sub-second resolution.
Upcoming inexpensive assays for the detection of SARS-CoV-2 RNA in less than one hour at points of care or at home should help suppress the COVID-19 pandemic.
Data from consumer smartwatches can improve the detection of COVID-19 when combined with symptom self-reporting, and can also detect the disease in pre-symptomatic individuals.
Proactive efforts towards the development of new vaccines and antivirals, and the elimination of bottlenecks in vaccine development, will be essential to containing and eradicating future pandemics.
More clinical trial data are needed to determine whether sera from COVID-19-convalescent patients and neutralizing monoclonal antibodies specific to SARS-CoV-2 antigens can prevent COVID-19 or reduce the severity of the disease in high-risk populations.
The stiffness of the extracellular matrix of gastric tumours reversibly regulates DNA methylation of the promoter region of the oncogenic Yes-associated protein.
A portable device integrating reverse transcription, fast thermocycling and in situ fluorescence detection accurately detects SARS-CoV-2 RNA in patient samples in 17 min.
Patches of transdermal core–shell microneedles, fabricated via additive manufacturing of polymer shells with varying degradability kinetics, enable the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month.
A portable prototype scanner for brain MRI that uses a compact and lightweight permanent rare-earth magnet with a built-in readout field gradient generates clinically relevant images of the brain, as shown in adult volunteers.
An open resource comprising chest computed tomography images and 130 clinical features of 1,521 patients with pneumonia, including COVID-19 pneumonia, facilitates the prediction of morbidity and mortality outcomes via deep learning.
Analysis of physiological and activity data from consumer smartwatches enables real-time detection, often before symptom onset, of COVID-19, as well as other respiratory illnesses and stress inducers.
The systemic administration of erythrocytes with chemokine-encapsulating nanoparticles non-covalently anchored to their surface results in local and systemic tumour suppression in mouse models of lung metastasis.