Review Articles

Filter By:

Article Type
  • This Review discusses the advantages and limitations of self-supervised methods and models for use in medicine and healthcare, and the challenges in collecting unbiased data for their training.

    • Rayan Krishnan
    • Pranav Rajpurkar
    • Eric J. Topol
    Review Article
  • This Review discusses established and emerging techniques for the multiplexed imaging of isolated tissues and cells and for non-invasive whole-body imaging.

    • Chrysafis Andreou
    • Ralph Weissleder
    • Moritz F. Kircher
    Review Article
  • This Review discusses the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal degeneration, as well as upcoming technologies for enhancing vision restoration.

    • Jasmina Cehajic-Kapetanovic
    • Mandeep S. Singh
    • Robert E. MacLaren
    Review Article
  • This Review describes the current optogenetics toolkit, and discusses its preclinical and translational applicability.

    • Akshaya Bansal
    • Swati Shikha
    • Yong Zhang
    Review Article
  • This Review examines classical methods for the preservation of mammalian biospecimens and the associated mechanisms of cryoinjury and discusses how the methods’ applicability limitations are being addressed.

    • Haishui Huang
    • Xiaoming He
    • Martin L. Yarmush
    Review Article
  • This Review summarizes the rapidly expanding toolbox of assays for CRISPR-based diagnostics and highlights their point-of-care applications.

    • Michael M. Kaminski
    • Omar O. Abudayyeh
    • James J. Collins
    Review Article
  • This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.

    • Ava M. Vargason
    • Aaron C. Anselmo
    • Samir Mitragotri
    Review Article
  • This Review Article discusses progress in the development of miniaturized and ultralightweight devices for neuroengineering that are wireless, battery-free and fully implantable.

    • Sang Min Won
    • Le Cai
    • John A. Rogers
    Review Article
  • This Review discusses methods for the creation of microphysiological human brain models that recapitulate aspects of major neurological disorders.

    • Hsih-Yin Tan
    • Hansang Cho
    • Luke P. Lee
    Review Article
  • This Review discusses non-invasive and invasive technologies for conveying artificial sensory feedback through bionic hands.

    • Sliman J. Bensmaia
    • Dustin J. Tyler
    • Silvestro Micera
    Review Article
  • This Review summarizes progress in the development of engineering strategies employed in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches.

    • Emma S. Gargus
    • Hunter B. Rogers
    • Teresa K. Woodruff
    Review Article
  • This Review summarizes the development of optoacoustic imaging with acoustic resolution and wide-bandwidth ultrasound detection, and the applicability of this mesoscopic imaging modality in the label-free visualization of tissue pathophysiology.

    • Murad Omar
    • Juan Aguirre
    • Vasilis Ntziachristos
    Review Article
  • This Review discusses the factors that affect the phenotypes of mesenchymal stromal cells, and the need for standardized assays that provide quality assurance for clinical uses of the cells.

    • James Q. Yin
    • Jun Zhu
    • James A. Ankrum
    Review Article
  • This Review summarizes the medical applications of artificial intelligence, and its economic, legal and social implications for healthcare.

    • Kun-Hsing Yu
    • Andrew L. Beam
    • Isaac S. Kohane
    Review Article
  • This Review discusses the manufacturing of cell products for clinically advanced cell therapies, and highlights potential manufacturing bottlenecks and solutions towards the cost-effective commercialization of the therapies.

    • Ayesha Aijaz
    • Matthew Li
    • Biju Parekkadan
    Review Article
  • This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.

    • Louai Labanieh
    • Robbie G. Majzner
    • Crystal L. Mackall
    Review Article