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    Systemically injected lipid–polymer nanoparticles delivering small interfering RNAs into bone-marrow endothelium modulate leukocyte trafficking from the bone marrow to the blood.

    • Ray P. Prajnamitra
    • , Hung-Chih Chen
    •  & Patrick C. H. Hsieh
  • News & Views |

    The delivery of drugs to the eye can be prolonged via a gelling hypotonic solution that forms a clear thin layer on the eye’s surface.

    • Ivan Seah
    • , Xian Jun Loh
    •  & Xinyi Su
  • News & Views |

    Systemic viral delivery of a gene encoding for a light-sensitive red-shifted ion channel enables non-invasive neuronal stimulation deep in the brain of rodents.

    • Shuo Chen
    •  & Thomas J. McHugh
  • News & Views |

    Wearable piezoelectric thin films integrated with multiphysics modelling and three-dimensional digital image correlation can decode facial expressions in real time.

    • Xiaoxiang Gao
    • , Xiangjun Chen
    •  & Sheng Xu
  • News & Views |

    Narrow-bandwidth signals and relaxed neural-recording parameters can substantially reduce the power requirements of brain–machine interfaces without degrading their performance.

    • Marc W. Slutzky
  • News & Views |

    Biomaterial structures can be printed with near-infrared light within the tissues of living animals by using photosensitive polymer hydrogels.

    • Mark W. Tibbitt
  • News & Views |

    Microwell arrays enable the culture of thousands of organoids with increased homogeneity, and facilitate high-content image-based analyses and high-throughput drug screens.

    • R. Jarrett Bliton
    •  & Scott T. Magness
  • News & Views |

    The oral delivery of a microencapsulated bacterial cocktail into animal models of kidney disease promotes the degradation of nitrogenous waste in the gut, thereby supporting renal function.

    • John Jarman
    •  & Dylan Dodd
  • News & Views |

    Positron emission tomography enables the tracking, in a mouse, of an intravenously injected cell radiolabelled with mesoporous silica nanoparticles containing 68Ga.

    • Guus A. M. S. van Dongen
    • , Ronald Boellaard
    •  & Danielle J. Vugts
  • News & Views |

    Lipofuscin, an endogenous pigment, can be used as a near-infrared fluorescent biomarker to stage and to monitor the progression of chronic liver disease, as shown in mice with induced liver disease and in human livers biopsied from patients with liver fibrosis.

    • Justin J. O’Sullivan
    • , Nathaniel H. O. Harder
    •  & Marie C. Heffern
  • News & Views |

    The cell-selective permeability of a retrievable microporous device encapsulating human therapeutic cells and implanted in the intraperitoneal space of mice provides long-term protection to the transplanted cells by dampening foreign-body responses and preventing the immune rejection of the graft.

    • Ken Coppieters
    • , Louise Winkel
    •  & Matthias von Herrath
  • News & Views |

    Neuropathologies can be classified, on the basis of post-mortem histopathology and by using machine learning, into six transdiagnostic clusters associated with clinical phenotypes.

    • Pablo Villoslada
    • , Ricardo Baeza-Yates
    •  & Joseph C. Masdeu
  • News & Views |

    Gold nanoclusters stabilized by the milk metalloprotein α-lactalbumin and displaying multicolour and multimodal fluorescence aid the detection, resection and treatment of breast tumours in mice.

    • Gang He
    • , Peng Huang
    •  & Xiaoyuan Chen
  • News & Views |

    In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.

    • Lahiru N. Wimalasena
    • , Lee E. Miller
    •  & Chethan Pandarinath
  • News & Views |

    The partial depletion of red blood cells via the administration of a low dose of anti-erythrocyte antibodies increases the circulation half-life of nanomedicines, as shown in rodent models of cancer.

    • Horacio Cabral
    •  & Kazunori Kataoka
  • News & Views |

    A custom fidget spinner that uses centrifugal forces to concentrate bacterial pathogens in urine samples enables the rapid on-device colorimetric detection of urinary tract infections and the testing of the pathogen’s susceptibility to antibiotics.

    • Hui Li
    • , Peter Torab
    •  & Pak Kin Wong
  • News & Views |

    An optofluidic chip incorporating a surface-enhanced Raman-scattering substrate rapidly detects picomolar concentrations of biomarkers of traumatic brain injury in finger-prick blood samples from patients.

    • Chunyan Li
    • , Kevin A. Shah
    •  & Raj K. Narayan
  • News & Views |

    The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.

    • Pedro Romero
    • , Alena Donda
    •  & Jeffrey A. Hubbell
  • News & Views |

    Biomarkers of health and disease in urine and stool can be longitudinally tracked with a ‘smart’ toilet incorporating biometric identification, pressure and motion sensors, urinalysis strips and a uroflowmeter.

    • Damir Brdjanovic
  • News & Views |

    The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.

    • Jürgen Scheller
    •  & Philipp A. Lang
  • News & Views |

    The selection of double-bridged peptides via in vitro phage display yields constrained cyclic peptides optimized for high therapeutic specificity and for stability against gastrointestinal proteases.

    • David J. Brayden
  • News & Views |

    The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.

    • Kim Henriksen
    •  & Morten A. Karsdal
  • News & Views |

    A robotic culture system for the high-throughput analysis of drug transport in porcine gastrointestinal tissue explants accurately predicts the absorption of orally taken drugs in the human gut.

    • Abdul W. Basit
    • , Christine M. Madla
    •  & Francesca K. H. Gavins
  • News & Views |

    Enhancing the binding of growth factors to heparan sulfate proteoglycans in the extracellular matrix and on cell surfaces improves wound healing and bone regeneration in mice.

    • Megan Lord
    • , John Whitelock
    •  & Jeremy E. Turnbull
  • News & Views |

    A vascularized bone-marrow-on-a-chip incorporating patient-derived CD34+ cells recapitulates haematopoietic defects associated with bone-marrow injury.

    • Michael Kyba
  • News & Views |

    Structural and functional changes following infarction in a human heart can be modelled with human cardiac organoids set in a hypoxic gradient and stimulated with the neurotransmitter noradrenaline.

    • Richard Mills
    •  & James Hudson
  • News & Views |

    The conversion of a deuterated substrate into cellular metabolites in vivo can be quantified via decreases in the proton nuclear magnetic resonance signals of these metabolites.

    • Peter C. M. van Zijl
    •  & Kevin M. Brindle
  • News & Views |

    The photothermal and magnetothermal properties of carbon-coated iron cobalt nanoparticles with a polymer shell make them sensitive tracers for in vivo magnetic particle imaging, magnetic resonance imaging and photoacoustic imaging.

    • Jose E. Perez
    • , Aurore Van de Walle
    •  & Claire Wilhelm
  • News & Views |

    An optical-imaging instrument that integrates multispectral imaging for the detection of fluorescence in the first and second near-infrared windows aids the surgical resection of liver tumours in patients.

    • Hak Soo Choi
    •  & Hyun Koo Kim
  • News & Views |

    The detection of small tumours with positron emission tomography is significantly enhanced by 64Cu-labelled polycationic polymers sensitive to the acidic pH of tumours.

    • Jianghong Rao
  • News & Views |

    Epithelial cancers of the upper intestinal tract in animals, in biopsied human tissue and in a human patient can be detected via a fluorescently labelled inhibitor of the DNA-repair enzyme poly(ADP-ribose) polymerase 1.

    • Guolan Lu
    •  & Eben L. Rosenthal
  • News & Views |

    Nanoscale strains in the intact whole joints of young, old and osteoarthritic mice can be resolved ex vivo via synchrotron X-ray tomography when combined with nanometrically precise mechanical loading.

    • Mariana E. Kersh
  • News & Views |

    Wireless and leadless millimetre-scale implantable pulse generators, powered and controlled by ultrasonic links, enable the electrical stimulation of neural pathways in anaesthetized rats.

    • Max Ortiz-Catalan
  • News & Views |

    Functionalized flexible helical bundles of carbon nanotubes serve as electrochemical sensors for long-term in vivo monitoring of disease biomarkers.

    • Ron Feiner
    •  & Tal Dvir
  • News & Views |

    An array of 4,096 nanoelectrodes can record and stimulate intracellular action potentials, as well as excitatory and inhibitory post-synaptic potentials, from thousands of connected mammalian neurons in culture.

    • Micha Spira
  • News & Views |

    An electrode array implanted into the optic nerve of rabbits selectively activates discrete regions of the primary visual cortex.

    • Shelley I. Fried
    •  & Mohit N. Shivdasani
  • News & Views |

    Locally delivering therapeutic T cells into solid tumours in mice via thin nitinol films loaded with the cells lengthens the animals’ survival.

    • Kwasi Adu-Berchie
    •  & David J. Mooney
  • News & Views |

    Negatively charged nanoparticles of about 50 nm in size permit the oral delivery of insulin and other peptide drugs by temporally enhancing the permeability of the intestinal wall.

    • Per Artursson
    •  & Patrik Lundquist
  • News & Views |

    In an adult mouse model of tyrosinaemia, a base editor correcting an A-to-G splice-site mutation in the Fah gene restores the translation of the functional enzyme, promoting the repopulation of the liver with the corrected cells.

    • Kiran Musunuru
  • News & Views |

    An injectable biomaterial vaccine encapsulating antigens associated with acute myeloid leukaemia, dendritic-cell-targeting pro-inflammatory cytokines and an adjuvant protects mice from the disease.

    • Guojun Chen
    •  & Zhen Gu
  • News & Views |

    The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

    • Monique A. J. van Eijndhoven
    • , S. Rubina Baglio
    •  & D. Michiel Pegtel
  • News & Views |

    Large quantities of extracellular vesicles produced via cellular nanoporation, and loaded with endogenously transcribed therapeutic mRNAs and targeting peptides, boost therapeutic outcomes in vivo.

    • Antje M. Zickler
    •  & Samir EL Andaloussi
  • News & Views |

    The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

    • Martin W. LaFleur
    • , Brian C. Miller
    •  & Arlene H. Sharpe
  • News & Views |

    A deep-learning algorithm trained with retinal images and subject metadata from the UK Biobank predicts blood-haemoglobin levels.

    • Yih-Chung Tham
    • , Ching Yu Cheng
    •  & Tien Yin Wong
  • News & Views |

    A non-invasive biomarker of the degree of collective order of monolayers of corneal endothelial cells cultured for transplantation predicts the long-term prognosis of corneal restoration in patients.

    • Jodhbir S. Mehta
    • , Viridiana Kocaba
    •  & Gary S. Peh
  • News & Views |

    The simultaneous removal of endogenous T-cell receptor α-chains and β-chains, and the orthotopic placement of an exogenous receptor in human T cells via CRISPR gene-editing, prevents the mispairing between endogenous and transgenic receptors while preserving the cells’ function.

    • Dian Kortleve
    • , Dora Hammerl
    •  & Reno Debets
  • News & Views |

    In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.

    • Tyler J. DiStefano
    • , Svenja Illien-Jünger
    •  & James C. Iatridis
  • News & Views |

    Functional changes in leukocytes isolated from 50-μL samples of peripheral blood from sepsis patients correlate with the patients’ clinical status.

    • Daniel Irimia