Articles

  • Article |

    The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.

    • Mohammad Ariful Islam
    • , Yingjie Xu
    • , Wei Tao
    • , Jessalyn M. Ubellacker
    • , Michael Lim
    • , Daniel Aum
    • , Gha Young Lee
    • , Kun Zhou
    • , Harshal Zope
    • , Mikyung Yu
    • , Wuji Cao
    • , James Trevor Oswald
    • , Meshkat Dinarvand
    • , Morteza Mahmoudi
    • , Robert Langer
    • , Philip W. Kantoff
    • , Omid C. Farokhzad
    • , Bruce R. Zetter
    •  & Jinjun Shi
  • Article |

    An assay that uses machine-learning algorithms on phenotypic-biomarker data from live primary cells predicts post-surgical adverse pathology in prostate-cancer and breast cancer tissue samples from patients.

    • Michael S. Manak
    • , Jonathan S. Varsanik
    • , Brad J. Hogan
    • , Matt J. Whitfield
    • , Wendell R. Su
    • , Nikhil Joshi
    • , Nicolai Steinke
    • , Andrew Min
    • , Delaney Berger
    • , Robert J. Saphirstein
    • , Gauri Dixit
    • , Thiagarajan Meyyappan
    • , Hui-May Chu
    • , Kevin B. Knopf
    • , David M. Albala
    • , Grannum R. Sant
    •  & Ashok C. Chander
  • Article |

    A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.

    • Ryan Snodgrass
    • , Andrea Gardner
    • , Aggrey Semeere
    • , Varun Lingaiah Kopparthy
    • , Jens Duru
    • , Toby Maurer
    • , Jeffrey Martin
    • , Ethel Cesarman
    •  & David Erickson
  • Article |

    An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

    • Chonghe Wang
    • , Xiaoshi Li
    • , Hongjie Hu
    • , Lin Zhang
    • , Zhenlong Huang
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Zhenan Yin
    • , Brady Huang
    • , Hua Gong
    • , Shubha Bhaskaran
    • , Yue Gu
    • , Mitsutoshi Makihata
    • , Yuxuan Guo
    • , Yusheng Lei
    • , Yimu Chen
    • , Chunfeng Wang
    • , Yang Li
    • , Tianjiao Zhang
    • , Zeyu Chen
    • , Albert P. Pisano
    • , Liangfang Zhang
    • , Qifa Zhou
    •  & Sheng Xu
  • Article |

    Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.

    • Zhen Ma
    • , Nathaniel Huebsch
    • , Sangmo Koo
    • , Mohammad A. Mandegar
    • , Brian Siemons
    • , Steven Boggess
    • , Bruce R. Conklin
    • , Costas P. Grigoropoulos
    •  & Kevin E. Healy
  • Article |

    A personalized virtual-heart model that determines optimal radio-frequency ablation targets for infarct-related tachycardia is validated in retrospective large-animal and patient studies, and in a prospective study in patients.

    • Adityo Prakosa
    • , Hermenegild J. Arevalo
    • , Dongdong Deng
    • , Patrick M. Boyle
    • , Plamen P. Nikolov
    • , Hiroshi Ashikaga
    • , Joshua J. E. Blauer
    • , Elyar Ghafoori
    • , Carolyn J. Park
    • , Robert C. Blake III
    • , Frederick T. Han
    • , Rob S. MacLeod
    • , Henry R. Halperin
    • , David J. Callans
    • , Ravi Ranjan
    • , Jonathan Chrispin
    • , Saman Nazarian
    •  & Natalia A. Trayanova
  • Article |

    Macromolecular telmisartan prodrugs optimized for preferential release in fibrotic liver tissue reduce liver fibrosis in mouse models, and are retained and well tolerated in the liver tissue of rats and dogs.

    • Matthew R. Golder
    • , Jenny Liu
    • , Jannik N. Andersen
    • , Michail V. Shipitsin
    • , Farrukh Vohidov
    • , Hung V.-T. Nguyen
    • , Deborah C. Ehrlich
    • , Sung Jin Huh
    • , Bhavatarini Vangamudi
    • , Kyriakos D. Economides
    • , Allison M. Neenan
    • , James C. Ackley
    • , Joelle Baddour
    • , Sattanathan Paramasivan
    • , Samantha W. Brady
    • , Eric J. Held
    • , Lawrence A. Reiter
    • , Jennifer K. Saucier-Sawyer
    • , Paul W. Kopesky
    • , Donald E. Chickering
    • , Peter Blume-Jensen
    •  & Jeremiah A. Johnson
  • Article |

    Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.

    • Matthew A. Bochenek
    • , Omid Veiseh
    • , Arturo J. Vegas
    • , James J. McGarrigle
    • , Meirigeng Qi
    • , Enza Marchese
    • , Mustafa Omami
    • , Joshua C. Doloff
    • , Joshua Mendoza-Elias
    • , Mohammad Nourmohammadzadeh
    • , Arshad Khan
    • , Chun-Chieh Yeh
    • , Yuan Xing
    • , Douglas Isa
    • , Sofia Ghani
    • , Jie Li
    • , Casey Landry
    • , Andrew R. Bader
    • , Karsten Olejnik
    • , Michael Chen
    • , Jennifer Hollister-Lock
    • , Yong Wang
    • , Dale L. Greiner
    • , Gordon C. Weir
    • , Berit Løkensgard Strand
    • , Anne Mari A. Rokstad
    • , Igor Lacik
    • , Robert Langer
    • , Daniel G. Anderson
    •  & Jose Oberholzer
  • Article |

    Coating the sensor in continuous glucose monitors with a zwitterionic polymer significantly reduces signal noise and the need for frequent device recalibration.

    • Xi Xie
    • , Joshua C. Doloff
    • , Volkan Yesilyurt
    • , Atieh Sadraei
    • , James J. McGarrigle
    • , Mustafa Omami
    • , Omid Veiseh
    • , Shady Farah
    • , Douglas Isa
    • , Sofia Ghani
    • , Ira Joshi
    • , Arturo Vegas
    • , Jie Li
    • , Weiheng Wang
    • , Andrew Bader
    • , Hok Hei Tam
    • , Jun Tao
    • , Hui-jiuan Chen
    • , Boru Yang
    • , Katrina Ann Williamson
    • , Jose Oberholzer
    • , Robert Langer
    •  & Daniel G. Anderson
  • Article |

    Scale models of the human left ventricle made of tissue-engineered nanofibrous scaffolds and primary rat cardiomyocytes or human-stem-cell-derived cardiomyocytes enable the study of contractile function and the modelling of structural arrhythmia.

    • Luke A. MacQueen
    • , Sean P. Sheehy
    • , Christophe O. Chantre
    • , John F. Zimmerman
    • , Francesco S. Pasqualini
    • , Xujie Liu
    • , Josue A. Goss
    • , Patrick H. Campbell
    • , Grant M. Gonzalez
    • , Sung-Jin Park
    • , Andrew K. Capulli
    • , John P. Ferrier
    • , T. Fettah Kosar
    • , L. Mahadevan
    • , William T. Pu
    •  & Kevin Kit Parker
  • Article |

    A low-cost point-of-care device that uses contrast-enhanced microholography and deep learning accurately detects aggressive lymphomas in patients referred for aspiration and biopsy of enlarged lymph nodes.

    • Hyungsoon Im
    • , Divya Pathania
    • , Philip J. McFarland
    • , Aliyah R. Sohani
    • , Ismail Degani
    • , Matthew Allen
    • , Benjamin Coble
    • , Aoife Kilcoyne
    • , Seonki Hong
    • , Lucas Rohrer
    • , Jeremy S. Abramson
    • , Scott Dryden-Peterson
    • , Lioubov Fexon
    • , Misha Pivovarov
    • , Bruce Chabner
    • , Hakho Lee
    • , Cesar M. Castro
    •  & Ralph Weissleder
  • Article |

    The combination of systemic immune checkpoint inhibition with local administration of a hydrogel containing the enzyme catalase, a radioisotope and an immunostimulatory agent promotes effective antitumour immune responses in mice models.

    • Yu Chao
    • , Ligeng Xu
    • , Chao Liang
    • , Liangzhu Feng
    • , Jun Xu
    • , Ziliang Dong
    • , Longlong Tian
    • , Xuan Yi
    • , Kai Yang
    •  & Zhuang Liu
  • Article |

    A magnetic wire for the intravascular recovery of labelled circulating tumour cells improves cell capture in anaesthetized pigs by up to two orders of magnitude with respect to a standard blood draw.

    • Ophir Vermesh
    • , Amin Aalipour
    • , T. Jessie Ge
    • , Yamil Saenz
    • , Yue Guo
    • , Israt S. Alam
    • , Seung-min Park
    • , Charlie N. Adelson
    • , Yoshiaki Mitsutake
    • , Jose Vilches-Moure
    • , Elias Godoy
    • , Michael H. Bachmann
    • , Chin Chun Ooi
    • , Jennifer K. Lyons
    • , Kerstin Mueller
    • , Hamed Arami
    • , Alfredo Green
    • , Edward I. Solomon
    • , Shan X. Wang
    •  & Sanjiv S. Gambhir
  • Article |

    Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

    • Yoonhee Jin
    • , Jung Seung Lee
    • , Jin Kim
    • , Sungjin Min
    • , Soohyun Wi
    • , Ji Hea Yu
    • , Gyeong-Eon Chang
    • , Ann-Na Cho
    • , Yeeun Choi
    • , Da-Hee Ahn
    • , Sung-Rae Cho
    • , Eunji Cheong
    • , Yun-Gon Kim
    • , Hyong-Pyo Kim
    • , Yonghwan Kim
    • , Dong Seok Kim
    • , Hyun Woo Kim
    • , Zhejiu Quan
    • , Hoon-Chul Kang
    •  & Seung-Woo Cho
  • Article |

    The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.

    • Jerzy O. Szablowski
    • , Audrey Lee-Gosselin
    • , Brian Lue
    • , Dina Malounda
    •  & Mikhail G. Shapiro
  • Article |

    A portable device enables the automated manufacturing of therapeutic-grade biologics in a few hours and under current good-manufacturing-practice conditions.

    • Rajani Adiga
    • , Mustafa Al-adhami
    • , Abhay Andar
    • , Shayan Borhani
    • , Sheniqua Brown
    • , David Burgenson
    • , Merideth A. Cooper
    • , Sevda Deldari
    • , Douglas D. Frey
    • , Xudong Ge
    • , Hui Guo
    • , Chandrasekhar Gurramkonda
    • , Penny Jensen
    • , Yordan Kostov
    • , William LaCourse
    • , Yang Liu
    • , Antonio Moreira
    • , KarunaSri Mupparapu
    • , Chariz Peñalber-Johnstone
    • , Manohar Pilli
    • , Benjamin Punshon-Smith
    • , Aniruddha Rao
    • , Govind Rao
    • , Priyanka Rauniyar
    • , Sergei Snovida
    • , Kanika Taurani
    • , Dagmawi Tilahun
    • , Leah Tolosa
    • , Michael Tolosa
    • , Kevin Tran
    • , Krishna Vattem
    • , Sudha Veeraraghavan
    • , Brandon Wagner
    • , Joshua Wilhide
    • , David W. Wood
    •  & Adil Zuber
  • Article |

    A supramolecule that inhibits the colony stimulating factor 1 and SIRPα receptors on macrophages significantly enhances antitumour and antimetastatic efficacies in two aggressive animal models of melanoma and breast cancer.

    • Ashish Kulkarni
    • , Vineethkrishna Chandrasekar
    • , Siva Kumar Natarajan
    • , Anujan Ramesh
    • , Prithvi Pandey
    • , Jayashree Nirgud
    • , Harshangda Bhatnagar
    • , Driti Ashok
    • , Amrendra Kumar Ajay
    •  & Shiladitya Sengupta
  • Article |

    Gene editing of a single gene in the brain of an adult mouse model of fragile X syndrome, achieved via the intracranial injection of a nonviral Cas9 delivery vehicle, rescues mice from the exaggerated repetitive behaviours caused by the disease.

    • Bumwhee Lee
    • , Kunwoo Lee
    • , Shree Panda
    • , Rodrigo Gonzales-Rojas
    • , Anthony Chong
    • , Vladislav Bugay
    • , Hyo Min Park
    • , Robert Brenner
    • , Niren Murthy
    •  & Hye Young Lee
  • Article |

    A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.

    • T. L. Edwards
    • , K. Xue
    • , H. C. M. Meenink
    • , M. J. Beelen
    • , G. J. L. Naus
    • , M. P. Simunovic
    • , M. Latasiewicz
    • , A. D. Farmery
    • , M. D. de Smet
    •  & R. E. MacLaren
  • Article |

    An epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium provides therapeutic benefits in a rat model of myocardial infarction.

    • William Whyte
    • , Ellen T. Roche
    • , Claudia E. Varela
    • , Keegan Mendez
    • , Shahrin Islam
    • , Hugh O’Neill
    • , Fiona Weafer
    • , Reyhaneh Neghabat Shirazi
    • , James C. Weaver
    • , Nikolay V. Vasilyev
    • , Peter E. McHugh
    • , Bruce Murphy
    • , Garry P. Duffy
    • , Conor J. Walsh
    •  & David J. Mooney
  • Article |

    Uniaxial strain provided by compressed nitinol springs incorporated in human intestinal organoids transplanted into the mouse mesentery enhances organoid growth and maturation, and improves the similarity of the organoids to native human intestine.

    • Holly M. Poling
    • , David Wu
    • , Nicole Brown
    • , Michael Baker
    • , Taylor A. Hausfeld
    • , Nhan Huynh
    • , Samuel Chaffron
    • , James C. Y. Dunn
    • , Simon P. Hogan
    • , James M. Wells
    • , Michael A. Helmrath
    •  & Maxime M. Mahe
  • Article |

    β-Cyclodextrin nanoparticles carrying an antagonist of the toll-like receptors TLR7 and TLR8 drive the M1 phenotype in tumour-associated macrophages and improve immunotherapy response rates in tumour mouse models when used with checkpoint blockade.

    • Christopher B. Rodell
    • , Sean P. Arlauckas
    • , Michael F. Cuccarese
    • , Christopher S. Garris
    • , Ran Li
    • , Maaz S. Ahmed
    • , Rainer H. Kohler
    • , Mikael J. Pittet
    •  & Ralph Weissleder
  • Article |

    Intracellular, intercellular and extracellular silicon interfaces enable light-controlled non-genetic modulation of intracellular calcium dynamics, of cellular excitability, of neurotransmitter release from brain slices, and of brain activity in vivo.

    • Yuanwen Jiang
    • , Xiaojian Li
    • , Bing Liu
    • , Jaeseok Yi
    • , Yin Fang
    • , Fengyuan Shi
    • , Xiang Gao
    • , Edward Sudzilovsky
    • , Ramya Parameswaran
    • , Kelliann Koehler
    • , Vishnu Nair
    • , Jiping Yue
    • , KuangHua Guo
    • , Yin Fang
    • , Hsiu-Ming Tsai
    • , George Freyermuth
    • , Raymond C. S. Wong
    • , Chien-Min Kao
    • , Chin-Tu Chen
    • , Alan W. Nicholls
    • , Xiaoyang Wu
    • , Gordon M. G. Shepherd
    •  & Bozhi Tian
  • Article |

    The modification of protein and peptide therapeutics with tannic acid improves their ability to specifically target heart tissue, as shown with a rat model of myocardial ischaemia-reperfusion injury.

    • Mikyung Shin
    • , Hyang-Ae Lee
    • , Mihyun Lee
    • , Yoomi Shin
    • , Ji-Joon Song
    • , Sun-Woong Kang
    • , Dae-Hwan Nam
    • , Eun Je Jeon
    • , Mira Cho
    • , Minjae Do
    • , SunHyun Park
    • , Moon Sue Lee
    • , Jae-Hyung Jang
    • , Seung-Woo Cho
    • , Ki-Suk Kim
    •  & Haeshin Lee
  • Article |

    A hydrogel patch for the sustained delivery of extracellular vesicles from cardiomyocytes derived from induced pluripotent stem cells improves tissue regeneration in infarcted rat hearts.

    • Bohao Liu
    • , Benjamin W. Lee
    • , Koki Nakanishi
    • , Aranzazu Villasante
    • , Rebecca Williamson
    • , Jordan Metz
    • , Jinho Kim
    • , Mariko Kanai
    • , Lynn Bi
    • , Kristy Brown
    • , Gilbert Di Paolo
    • , Shunichi Homma
    • , Peter A. Sims
    • , Veli K. Topkara
    •  & Gordana Vunjak-Novakovic
  • Article |

    A cell-culture method involving decellularized tissue scaffolds enables the spontaneous formation of cell colonies that phenotypically recapitulate in vivo organ-specific cancer metastases.

    • Xi Tian
    • , Michael E. Werner
    • , Kyle C. Roche
    • , Ariel D. Hanson
    • , Henry P. Foote
    • , Stephanie K. Yu
    • , Samuel B. Warner
    • , Jonathan A. Copp
    • , Haydee Lara
    • , Eliane L. Wauthier
    • , Joseph M. Caster
    • , Laura E. Herring
    • , Longzhen Zhang
    • , Joel E. Tepper
    • , David S. Hsu
    • , Tian Zhang
    • , Lola M. Reid
    •  & Andrew Z. Wang
  • Article |

    An endothelialized microfluidic system that recapitulates physiological properties of the microvasculature enables the real-time visualization of vascular-pathology features associated with sickle-cell disease and malaria, with high spatiotemporal resolution.

    • Yongzhi Qiu
    • , Byungwook Ahn
    • , Yumiko Sakurai
    • , Caroline E. Hansen
    • , Reginald Tran
    • , Patrice N. Mimche
    • , Robert G. Mannino
    • , Jordan C. Ciciliano
    • , Tracey J. Lamb
    • , Clinton H. Joiner
    • , Solomon F. Ofori-Acquah
    •  & Wilbur A. Lam
  • Article |

    A nanoparticle-based immunotherapy targeted to a protein responsible for signalling between monocytes and macrophages reduces plaque inflammation in atherosclerotic mice and appears to be safe in non-human primates.

    • Marnix Lameijer
    • , Tina Binderup
    • , Mandy M. T. van Leent
    • , Max L. Senders
    • , Francois Fay
    • , Joost Malkus
    • , Brenda L. Sanchez-Gaytan
    • , Abraham J. P. Teunissen
    • , Nicolas Karakatsanis
    • , Philip Robson
    • , Xianxiao Zhou
    • , Yuxiang Ye
    • , Gregory Wojtkiewicz
    • , Jun Tang
    • , Tom T. P. Seijkens
    • , Jeffrey Kroon
    • , Erik S. G. Stroes
    • , Andreas Kjaer
    • , Jordi Ochando
    • , Thomas Reiner
    • , Carlos Pérez-Medina
    • , Claudia Calcagno
    • , Edward A. Fisher
    • , Bin Zhang
    • , Ryan E. Temel
    • , Filip K. Swirski
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    • , Esther Lutgens
    • , Willem J. M. Mulder
    •  & Raphaël Duivenvoorden
  • Article |

    Topically applied imaging nanoprobes for the detection of intracellular mRNA expression from connective tissue growth factor enable the detection of hypertrophic scars and keloids in the skin of small live animals and in ex vivo human skin.

    • David C. Yeo
    • , Christian Wiraja
    • , Amy S. Paller
    • , Chad A. Mirkin
    •  & Chenjie Xu
  • Article |

    A method that uses thin sheets of X-ray radiation to generate emissions of Cherenkov luminescence can image an oxygen-sensitive molecular probe to map oxygenation in tumours in vivo at submillimetre resolution and nanomolar sensitivity.

    • Brian W. Pogue
    • , Jinchao Feng
    • , Ethan P. LaRochelle
    • , Petr Bruža
    • , Huiyun Lin
    • , Rongxiao Zhang
    • , Jennifer R. Shell
    • , Hamid Dehghani
    • , Scott C. Davis
    • , Sergei A. Vinogradov
    • , David J. Gladstone
    •  & Lesley A. Jarvis
  • Article |

    A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.

    • Anthony G. Christodoulou
    • , Jaime L. Shaw
    • , Christopher Nguyen
    • , Qi Yang
    • , Yibin Xie
    • , Nan Wang
    •  & Debiao Li
  • Article |

    Culturing conditions affect the transcriptomic profiles of induced neuronal cells, and 3D co-cultures of induced neuronal cells and astrocytic cells can be rapidly generated from the same pool of human embryonic stem cells.

    • Halil Tekin
    • , Sean Simmons
    • , Beryl Cummings
    • , Linyi Gao
    • , Xian Adiconis
    • , Cynthia C. Hession
    • , Ayan Ghoshal
    • , Danielle Dionne
    • , Sourav R. Choudhury
    • , Volkan Yesilyurt
    • , Neville E. Sanjana
    • , Xi Shi
    • , Congyi Lu
    • , Matthias Heidenreich
    • , Jen Q. Pan
    • , Joshua Z. Levin
    •  & Feng Zhang
  • Article |

    Self-assembled ribonucleoprotein octamers bearing an endosomolytic peptide and a siRNA–targeting-ligand conjugate facilitate endosomal destabilization and targeted delivery, achieving efficient gene silencing in mouse models of prostate cancer.

    • Wanyi Tai
    • , Junwei Li
    • , Eva Corey
    •  & Xiaohu Gao
  • Article |

    The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.

    • Hong-Won Lee
    • , Byoungsan Choi
    • , Han Na Kang
    • , Hyunwoo Kim
    • , Ahrum Min
    • , Minkwon Cha
    • , Ji Young Ryu
    • , Sangwoo Park
    • , Jinyoung Sohn
    • , Kihyuk Shin
    • , Mi Ran Yun
    • , Joo Yeun Han
    • , Min Ju Shon
    • , Cherlhyun Jeong
    • , Junho Chung
    • , Seung-Hyo Lee
    • , Seock-Ah Im
    • , Byoung Chul Cho
    •  & Tae-Young Yoon
  • Article |

    Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.

    • Kuangda Lu
    • , Chunbai He
    • , Nining Guo
    • , Christina Chan
    • , Kaiyuan Ni
    • , Guangxu Lan
    • , Haidong Tang
    • , Charles Pelizzari
    • , Yang-Xin Fu
    • , Michael T. Spiotto
    • , Ralph R. Weichselbaum
    •  & Wenbin Lin
  • Article |

    A microfluidics-based sequencing method that profiles genome-wide DNA methylation using only sub-nanogram quantities of DNA finds distinct DNA methylome patterns in glial and neuronal cell nuclei from mouse brains treated with an antipsychotic drug.

    • Sai Ma
    • , Mario de la Fuente Revenga
    • , Zhixiong Sun
    • , Chen Sun
    • , Travis W. Murphy
    • , Hehuang Xie
    • , Javier González-Maeso
    •  & Chang Lu
  • Article |

    A new chemically defined culture medium for the long-term culture of human pluripotent stem cells uses only three chemical compounds and a lower number of recombinant proteins than used in commercially available media.

    • Shin-ya Yasuda
    • , Tatsuhiko Ikeda
    • , Hosein Shahsavarani
    • , Noriko Yoshida
    • , Bhavana Nayer
    • , Motoki Hino
    • , Neha Vartak-Sharma
    • , Hirofumi Suemori
    •  & Kouichi Hasegawa
  • Article |

    An ultrathin, needle-shaped piezoelectric microsystem that can be injected or mounted onto conventional biopsy needles measures variations in tissue modulus in real time and can thus be used to distinguish abnormal from healthy tissue.

    • Xinge Yu
    • , Heling Wang
    • , Xin Ning
    • , Rujie Sun
    • , Hassan Albadawi
    • , Marcela Salomao
    • , Alvin C. Silva
    • , Yang Yu
    • , Limei Tian
    • , Ahyeon Koh
    • , Chan Mi Lee
    • , Aditya Chempakasseril
    • , Peilin Tian
    • , Matt Pharr
    • , Jianghong Yuan
    • , Yonggang Huang
    • , Rahmi Oklu
    •  & John A. Rogers
  • Article |

    A compact, self-contained device bearing an array of microneedles collects 100 μl of blood at the push of a button, and is more convenient and less painful than a fingerstick and venepuncture.

    • Timothy M. Blicharz
    • , Ping Gong
    • , Bernard M. Bunner
    • , Larry L. Chu
    • , Kaela M. Leonard
    • , Jessica A. Wakefield
    • , Richard E. Williams
    • , Maisam Dadgar
    • , Carlo A. Tagliabue
    • , Ragheb El Khaja
    • , Stephanie L. Marlin
    • , Ramin Haghgooie
    • , Shawn P. Davis
    • , Donald E. Chickering
    •  & Howard Bernstein
  • Article |

    The slow release of pro-survival peptide analogues crosslinked to an injectable collagen–dendrimer biomaterial significantly prolongs the engraftment and survival of transplanted stem cells in mouse models of ischaemic injury.

    • Andrew S. Lee
    • , Mohammed Inayathullah
    • , Maarten A. Lijkwan
    • , Xin Zhao
    • , Wenchao Sun
    • , Sujin Park
    • , Wan Xing Hong
    • , Mansi B. Parekh
    • , Andrey V. Malkovskiy
    • , Edward Lau
    • , Xulei Qin
    • , Venkata Raveendra Pothineni
    • , Verónica Sanchez-Freire
    • , Wendy Y. Zhang
    • , Nigel G. Kooreman
    • , Antje D. Ebert
    • , Charles K. F. Chan
    • , Patricia K. Nguyen
    • , Jayakumar Rajadas
    •  & Joseph C. Wu
  • Article |

    Cells engineered to produce an analgesic in response to spearmint aroma and implanted in mouse models of chronic pain reduce the pain-associated behaviour after oral intake of spearmint essential oil with no adverse effects.

    • Hui Wang
    • , Mingqi Xie
    • , Ghislaine Charpin-El Hamri
    • , Haifeng Ye
    •  & Martin Fussenegger
  • Article |

    A system that combines positron emission tomography, computed tomography and ultrafast ultrasound allows for simultaneous multi-parametric imaging in animal models.

    • Jean Provost
    • , Anikitos Garofalakis
    • , Joevin Sourdon
    • , Damien Bouda
    • , Béatrice Berthon
    • , Thomas Viel
    • , Mailyn Perez-Liva
    • , Charlotte Lussey-Lepoutre
    • , Judith Favier
    • , Mafalda Correia
    • , Mathieu Pernot
    • , Johanna Chiche
    • , Jacques Pouysségur
    • , Mickael Tanter
    •  & Bertrand Tavitian