Articles

  • Article |

    A first-in-man study of robotic-assisted intraocular surgery shows the feasibility and safety of the robotic device for the peeling of retinal membranes and for the injection of a therapeutic under the retina.

    • T. L. Edwards
    • , K. Xue
    • , H. C. M. Meenink
    • , M. J. Beelen
    • , G. J. L. Naus
    • , M. P. Simunovic
    • , M. Latasiewicz
    • , A. D. Farmery
    • , M. D. de Smet
    •  & R. E. MacLaren
  • Article |

    An epicardial device that enables sustained and repeated administration of small molecules, macromolecules and cells directly to the epicardium provides therapeutic benefits in a rat model of myocardial infarction.

    • William Whyte
    • , Ellen T. Roche
    • , Claudia E. Varela
    • , Keegan Mendez
    • , Shahrin Islam
    • , Hugh O’Neill
    • , Fiona Weafer
    • , Reyhaneh Neghabat Shirazi
    • , James C. Weaver
    • , Nikolay V. Vasilyev
    • , Peter E. McHugh
    • , Bruce Murphy
    • , Garry P. Duffy
    • , Conor J. Walsh
    •  & David J. Mooney
  • Article |

    Uniaxial strain provided by compressed nitinol springs incorporated in human intestinal organoids transplanted into the mouse mesentery enhances organoid growth and maturation, and improves the similarity of the organoids to native human intestine.

    • Holly M. Poling
    • , David Wu
    • , Nicole Brown
    • , Michael Baker
    • , Taylor A. Hausfeld
    • , Nhan Huynh
    • , Samuel Chaffron
    • , James C. Y. Dunn
    • , Simon P. Hogan
    • , James M. Wells
    • , Michael A. Helmrath
    •  & Maxime M. Mahe
  • Article |

    β-Cyclodextrin nanoparticles carrying an antagonist of the toll-like receptors TLR7 and TLR8 drive the M1 phenotype in tumour-associated macrophages and improve immunotherapy response rates in tumour mouse models when used with checkpoint blockade.

    • Christopher B. Rodell
    • , Sean P. Arlauckas
    • , Michael F. Cuccarese
    • , Christopher S. Garris
    • , Ran Li
    • , Maaz S. Ahmed
    • , Rainer H. Kohler
    • , Mikael J. Pittet
    •  & Ralph Weissleder
  • Article |

    Intracellular, intercellular and extracellular silicon interfaces enable light-controlled non-genetic modulation of intracellular calcium dynamics, of cellular excitability, of neurotransmitter release from brain slices, and of brain activity in vivo.

    • Yuanwen Jiang
    • , Xiaojian Li
    • , Bing Liu
    • , Jaeseok Yi
    • , Yin Fang
    • , Fengyuan Shi
    • , Xiang Gao
    • , Edward Sudzilovsky
    • , Ramya Parameswaran
    • , Kelliann Koehler
    • , Vishnu Nair
    • , Jiping Yue
    • , KuangHua Guo
    • , Yin Fang
    • , Hsiu-Ming Tsai
    • , George Freyermuth
    • , Raymond C. S. Wong
    • , Chien-Min Kao
    • , Chin-Tu Chen
    • , Alan W. Nicholls
    • , Xiaoyang Wu
    • , Gordon M. G. Shepherd
    •  & Bozhi Tian
  • Article |

    The modification of protein and peptide therapeutics with tannic acid improves their ability to specifically target heart tissue, as shown with a rat model of myocardial ischaemia-reperfusion injury.

    • Mikyung Shin
    • , Hyang-Ae Lee
    • , Mihyun Lee
    • , Yoomi Shin
    • , Ji-Joon Song
    • , Sun-Woong Kang
    • , Dae-Hwan Nam
    • , Eun Je Jeon
    • , Mira Cho
    • , Minjae Do
    • , SunHyun Park
    • , Moon Sue Lee
    • , Jae-Hyung Jang
    • , Seung-Woo Cho
    • , Ki-Suk Kim
    •  & Haeshin Lee
  • Article |

    A hydrogel patch for the sustained delivery of extracellular vesicles from cardiomyocytes derived from induced pluripotent stem cells improves tissue regeneration in infarcted rat hearts.

    • Bohao Liu
    • , Benjamin W. Lee
    • , Koki Nakanishi
    • , Aranzazu Villasante
    • , Rebecca Williamson
    • , Jordan Metz
    • , Jinho Kim
    • , Mariko Kanai
    • , Lynn Bi
    • , Kristy Brown
    • , Gilbert Di Paolo
    • , Shunichi Homma
    • , Peter A. Sims
    • , Veli K. Topkara
    •  & Gordana Vunjak-Novakovic
  • Article |

    A cell-culture method involving decellularized tissue scaffolds enables the spontaneous formation of cell colonies that phenotypically recapitulate in vivo organ-specific cancer metastases.

    • Xi Tian
    • , Michael E. Werner
    • , Kyle C. Roche
    • , Ariel D. Hanson
    • , Henry P. Foote
    • , Stephanie K. Yu
    • , Samuel B. Warner
    • , Jonathan A. Copp
    • , Haydee Lara
    • , Eliane L. Wauthier
    • , Joseph M. Caster
    • , Laura E. Herring
    • , Longzhen Zhang
    • , Joel E. Tepper
    • , David S. Hsu
    • , Tian Zhang
    • , Lola M. Reid
    •  & Andrew Z. Wang
  • Article |

    An endothelialized microfluidic system that recapitulates physiological properties of the microvasculature enables the real-time visualization of vascular-pathology features associated with sickle-cell disease and malaria, with high spatiotemporal resolution.

    • Yongzhi Qiu
    • , Byungwook Ahn
    • , Yumiko Sakurai
    • , Caroline E. Hansen
    • , Reginald Tran
    • , Patrice N. Mimche
    • , Robert G. Mannino
    • , Jordan C. Ciciliano
    • , Tracey J. Lamb
    • , Clinton H. Joiner
    • , Solomon F. Ofori-Acquah
    •  & Wilbur A. Lam
  • Article |

    A nanoparticle-based immunotherapy targeted to a protein responsible for signalling between monocytes and macrophages reduces plaque inflammation in atherosclerotic mice and appears to be safe in non-human primates.

    • Marnix Lameijer
    • , Tina Binderup
    • , Mandy M. T. van Leent
    • , Max L. Senders
    • , Francois Fay
    • , Joost Malkus
    • , Brenda L. Sanchez-Gaytan
    • , Abraham J. P. Teunissen
    • , Nicolas Karakatsanis
    • , Philip Robson
    • , Xianxiao Zhou
    • , Yuxiang Ye
    • , Gregory Wojtkiewicz
    • , Jun Tang
    • , Tom T. P. Seijkens
    • , Jeffrey Kroon
    • , Erik S. G. Stroes
    • , Andreas Kjaer
    • , Jordi Ochando
    • , Thomas Reiner
    • , Carlos Pérez-Medina
    • , Claudia Calcagno
    • , Edward A. Fischer
    • , Bin Zhang
    • , Ryan E. Temel
    • , Filip K. Swirski
    • , Matthias Nahrendorf
    • , Zahi A. Fayad
    • , Esther Lutgens
    • , Willem J. M. Mulder
    •  & Raphaël Duivenvoorden
  • Article |

    Topically applied imaging nanoprobes for the detection of intracellular mRNA expression from connective tissue growth factor enable the detection of hypertrophic scars and keloids in the skin of small live animals and in ex vivo human skin.

    • David C. Yeo
    • , Christian Wiraja
    • , Amy S. Paller
    • , Chad A. Mirkin
    •  & Chenjie Xu
  • Article |

    A method that uses thin sheets of X-ray radiation to generate emissions of Cherenkov luminescence can image an oxygen-sensitive molecular probe to map oxygenation in tumours in vivo at submillimetre resolution and nanomolar sensitivity.

    • Brian W. Pogue
    • , Jinchao Feng
    • , Ethan P. LaRochelle
    • , Petr Bruža
    • , Huiyun Lin
    • , Rongxiao Zhang
    • , Jennifer R. Shell
    • , Hamid Dehghani
    • , Scott C. Davis
    • , Sergei A. Vinogradov
    • , David J. Gladstone
    •  & Lesley A. Jarvis
  • Article |

    A continuous-acquisition method for reducing artefacts caused by the beating heart and other body motions in cardiovascular magnetic resonance imaging reduces the reliance on electrocardiography triggering and breath holds.

    • Anthony G. Christodoulou
    • , Jaime L. Shaw
    • , Christopher Nguyen
    • , Qi Yang
    • , Yibin Xie
    • , Nan Wang
    •  & Debiao Li
  • Article |

    Culturing conditions affect the transcriptomic profiles of induced neuronal cells, and 3D co-cultures of induced neuronal cells and astrocytic cells can be rapidly generated from the same pool of human embryonic stem cells.

    • Halil Tekin
    • , Sean Simmons
    • , Beryl Cummings
    • , Linyi Gao
    • , Xian Adiconis
    • , Cynthia C. Hession
    • , Ayan Ghoshal
    • , Danielle Dionne
    • , Sourav R. Choudhury
    • , Volkan Yesilyurt
    • , Neville E. Sanjana
    • , Xi Shi
    • , Congyi Lu
    • , Matthias Heidenreich
    • , Jen Q. Pan
    • , Joshua Z. Levin
    •  & Feng Zhang
  • Article |

    Self-assembled ribonucleoprotein octamers bearing an endosomolytic peptide and a siRNA–targeting-ligand conjugate facilitate endosomal destabilization and targeted delivery, achieving efficient gene silencing in mouse models of prostate cancer.

    • Wanyi Tai
    • , Junwei Li
    • , Eva Corey
    •  & Xiaohu Gao
  • Article |

    The characterization of protein–protein interactions by combined single-molecule pull-down and single-molecule co-immunoprecipitation assays uncovers, for specific cancers, their dependence on signalling complexes of the human epidermal growth-factor receptor.

    • Hong-Won Lee
    • , Byoungsan Choi
    • , Han Na Kang
    • , Hyunwoo Kim
    • , Ahrum Min
    • , Minkwon Cha
    • , Ji Young Ryu
    • , Sangwoo Park
    • , Jinyoung Sohn
    • , Kihyuk Shin
    • , Mi Ran Yun
    • , Joo Yeun Han
    • , Min Ju Shon
    • , Cherlhyun Jeong
    • , Junho Chung
    • , Seung-Hyo Lee
    • , Seock-Ah Im
    • , Byoung Chul Cho
    •  & Tae-Young Yoon
  • Article |

    Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.

    • Kuangda Lu
    • , Chunbai He
    • , Nining Guo
    • , Christina Chan
    • , Kaiyuan Ni
    • , Guangxu Lan
    • , Haidong Tang
    • , Charles Pelizzari
    • , Yang-Xin Fu
    • , Michael T. Spiotto
    • , Ralph R. Weichselbaum
    •  & Wenbin Lin
  • Article |

    A microfluidics-based sequencing method that profiles genome-wide DNA methylation using only sub-nanogram quantities of DNA finds distinct DNA methylome patterns in glial and neuronal cell nuclei from mouse brains treated with an antipsychotic drug.

    • Sai Ma
    • , Mario de la Fuente Revenga
    • , Zhixiong Sun
    • , Chen Sun
    • , Travis W. Murphy
    • , Hehuang Xie
    • , Javier González-Maeso
    •  & Chang Lu
  • Article |

    A new chemically defined culture medium for the long-term culture of human pluripotent stem cells uses only three chemical compounds and a lower number of recombinant proteins than used in commercially available media.

    • Shin-ya Yasuda
    • , Tatsuhiko Ikeda
    • , Hosein Shahsavarani
    • , Noriko Yoshida
    • , Bhavana Nayer
    • , Motoki Hino
    • , Neha Vartak-Sharma
    • , Hirofumi Suemori
    •  & Kouichi Hasegawa
  • Article |

    An ultrathin, needle-shaped piezoelectric microsystem that can be injected or mounted onto conventional biopsy needles measures variations in tissue modulus in real time and can thus be used to distinguish abnormal from healthy tissue.

    • Xinge Yu
    • , Heling Wang
    • , Xin Ning
    • , Rujie Sun
    • , Hassan Albadawi
    • , Marcela Salomao
    • , Alvin C. Silva
    • , Yang Yu
    • , Limei Tian
    • , Ahyeon Koh
    • , Chan Mi Lee
    • , Aditya Chempakasseril
    • , Peilin Tian
    • , Matt Pharr
    • , Jianghong Yuan
    • , Yonggang Huang
    • , Rahmi Oklu
    •  & John A. Rogers
  • Article |

    A compact, self-contained device bearing an array of microneedles collects 100 μl of blood at the push of a button, and is more convenient and less painful than a fingerstick and venepuncture.

    • Timothy M. Blicharz
    • , Ping Gong
    • , Bernard M. Bunner
    • , Larry L. Chu
    • , Kaela M. Leonard
    • , Jessica A. Wakefield
    • , Richard E. Williams
    • , Maisam Dadgar
    • , Carlo A. Tagliabue
    • , Ragheb El Khaja
    • , Stephanie L. Marlin
    • , Ramin Haghgooie
    • , Shawn P. Davis
    • , Donald E. Chickering
    •  & Howard Bernstein