Articles

  • Article |

    An analysis of a proteomics database of leukaemia cell lines and samples from patients with acute myelogenous leukaemia uncovers heterogeneity in protein expression as well as proteomic hallmarks and signatures for patient stratification.

    • C. W. Hu
    • , Y. Qiu
    • , A. Ligeralde
    • , A. Y. Raybon
    • , S. Y. Yoo
    • , K. R. Coombes
    • , A. A. Qutub
    •  & S. M. Kornblau
  • Article |

    A viscoelastic adhesive patch that accommodates the myocardium’s cyclic deformation outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and in restoring heart function after myocardial infarction in rats.

    • Xiao Lin
    • , Yue Liu
    • , Aobing Bai
    • , Huanhuan Cai
    • , Yanjie Bai
    • , Wei Jiang
    • , Huilin Yang
    • , Xinhong Wang
    • , Lei Yang
    • , Ning Sun
    •  & Huajian Gao
  • Article |

    A comparison of the molecular, cellular and functional characteristics of three congruent patient-specific cell types for the modelling of Charcot−Marie−Tooth 1A reveals commonly upregulated chemokines.

    • Bipasha Mukherjee-Clavin
    • , Ruifa Mi
    • , Barbara Kern
    • , In Young Choi
    • , Hotae Lim
    • , Yohan Oh
    • , Benjamin Lannon
    • , Kevin J. Kim
    • , Shaughn Bell
    • , Junho K. Hur
    • , Woochang Hwang
    • , Young Hyun Che
    • , Omer Habib
    • , Robert H. Baloh
    • , Kevin Eggan
    • , Gerald Brandacher
    • , Ahmet Hoke
    • , Lorenz Studer
    • , Yong Jun Kim
    •  & Gabsang Lee
  • Article |

    A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.

    • Zengping Liu
    • , Sing Shy Liow
    • , Siew Li Lai
    • , Asfa Alli-Shaik
    • , Graham E. Holder
    • , Bhav Harshad Parikh
    • , Subramanian Krishnakumar
    • , Zibiao Li
    • , Mein Jin Tan
    • , Jayantha Gunaratne
    • , Veluchamy Amutha Barathi
    • , Walter Hunziker
    • , Rajamani Lakshminarayanan
    • , Clement Woon Teck Tan
    • , Caroline K. Chee
    • , Paul Zhao
    • , Gopal Lingam
    • , Xian Jun Loh
    •  & Xinyi Su
  • Article |

    A nanomedicine encapsulating a docetaxel prodrug, and conjugated to an antibody specific for the receptor EphA2, provides enhanced antitumour activity in multiple tumour-xenografted mice, and has minimal toxicity in rats and dogs.

    • Walid S. Kamoun
    • , Dmitri B. Kirpotin
    • , Zhaohua Richard Huang
    • , Suresh K. Tipparaju
    • , Charles O. Noble
    • , Mark E. Hayes
    • , Lia Luus
    • , Alexander Koshkaryev
    • , Jaeyeon Kim
    • , Ken Olivier
    • , Tad Kornaga
    • , Shinji Oyama
    • , Vasileios Askoxylakis
    • , Christine Pien
    • , Geoffrey Kuesters
    • , Nancy Dumont
    • , Alexey A. Lugovskoy
    • , Sarah A. Schihl
    • , John H. Wilton
    • , Melissa L. Geddie
    • , James Suchy
    • , Stephanie Grabow
    • , Neeraj Kohli
    • , C. Patrick Reynolds
    • , Rachel Blaydes
    • , Yu Zhou
    • , Andrew J. Sawyer
    • , James D. Marks
    •  & Daryl C. Drummond
  • Article |

    A dual positron emission tomography–near-infrared probe enables the visualization of the early trafficking dynamics of an injected model mRNA vaccine in non-human primates.

    • Kevin E. Lindsay
    • , Sushma M. Bhosle
    • , Chiara Zurla
    • , Jared Beyersdorf
    • , Kenneth A. Rogers
    • , Daryll Vanover
    • , Peng Xiao
    • , Mariluz Araínga
    • , Lisa M. Shirreff
    • , Bruno Pitard
    • , Patrick Baumhof
    • , Francois Villinger
    •  & Philip J. Santangelo
  • Article |

    A suite of glass pipettes with integrated microelectrodes that simultaneously acquire intracellular and extracellular data in living mice and rats yield ground-truth data for validation of the performance of spike-sorting algorithms.

    • David L. Hunt
    • , Chongxi Lai
    • , Richard D. Smith
    • , Albert K. Lee
    • , Timothy D. Harris
    •  & Mladen Barbic
  • Article |

    Optoacoustic neuroimaging of mice expressing a genetically encoded calcium indicator allows for rapid, high-resolution, whole-brain 3D snapshots of neuronal calcium activity and haemodynamics.

    • Sven Gottschalk
    • , Oleksiy Degtyaruk
    • , Benedict Mc Larney
    • , Johannes Rebling
    • , Magdalena Anastasia Hutter
    • , Xosé Luís Deán-Ben
    • , Shy Shoham
    •  & Daniel Razansky
  • Article |

    An electrical biosensor combining CRISPR–Cas9 and a graphene field-effect transistor detects target genes in purified genomic samples at high sensitivity, within 15 minutes, and without the need for amplification.

    • Reza Hajian
    • , Sarah Balderston
    • , Thanhtra Tran
    • , Tara deBoer
    • , Jessy Etienne
    • , Mandeep Sandhu
    • , Noreen A. Wauford
    • , Jing-Yi Chung
    • , Jolie Nokes
    • , Mitre Athaiya
    • , Jacobo Paredes
    • , Regis Peytavi
    • , Brett Goldsmith
    • , Niren Murthy
    • , Irina M. Conboy
    •  & Kiana Aran
  • Article |

    The physiological degradation of programmed-death ligand 1 is reduced by the palmitoylation of its intracellular domain, and this process can be inhibited to promote T-cell immunity against tumours.

    • Han Yao
    • , Jiang Lan
    • , Chushu Li
    • , Hubing Shi
    • , Jean-Philippe Brosseau
    • , Huanbin Wang
    • , Haojie Lu
    • , Caiyun Fang
    • , Yao Zhang
    • , Lunxi Liang
    • , Xiaolin Zhou
    • , Chaojun Wang
    • , Yu Xue
    • , Yun Cui
    •  & Jie Xu
  • Article |

    A tumour-on-a-chip model featuring patient-derived glioblastoma cells, vascular endothelial cells and decellularized extracellular matrix from brain tissue can be used to identify patient-specific resistance to standard chemoradiotherapy.

    • Hee-Gyeong Yi
    • , Young Hun Jeong
    • , Yona Kim
    • , Yeong-Jin Choi
    • , Hyo Eun Moon
    • , Sung Hye Park
    • , Kyung Shin Kang
    • , Mihyeon Bae
    • , Jinah Jang
    • , Hyewon Youn
    • , Sun Ha Paek
    •  & Dong-Woo Cho
  • Article |

    A microphysiological model of the bronchial airways enables the study of the mechanochemical feedback interactions between smooth muscle cells and epithelial cells that underlie bronchospasm.

    • Onur Kilic
    • , Arum Yoon
    • , Sagar R. Shah
    • , Hwan Mee Yong
    • , Alejandro Ruiz-Valls
    • , Hao Chang
    • , Reynold A. Panettieri Jr
    • , Stephen B. Liggett
    • , Alfredo Quiñones-Hinojosa
    • , Steven S. An
    •  & Andre Levchenko
  • Article |

    Deep learning can be used to virtually stain autofluorescence images of unlabelled tissue sections, generating images that are equivalent to the histologically stained versions.

    • Yair Rivenson
    • , Hongda Wang
    • , Zhensong Wei
    • , Kevin de Haan
    • , Yibo Zhang
    • , Yichen Wu
    • , Harun Günaydın
    • , Jonathan E. Zuckerman
    • , Thomas Chong
    • , Anthony E. Sisk
    • , Lindsey M. Westbrook
    • , W. Dean Wallace
    •  & Aydogan Ozcan
  • Article |

    An immunotoxin incorporating an anti-programmed-cell-death-protein-1 (PD-1) single-chain variable fragment selectively eliminates PD-1-expressing cells, and suppresses autoimmunity while preserving adaptive immunity in mouse models of autoimmune disease.

    • Peng Zhao
    • , Peng Wang
    • , Shuyun Dong
    • , Zemin Zhou
    • , Yanguang Cao
    • , Hideo Yagita
    • , Xiao He
    • , Song Guo Zheng
    • , Simon J. Fisher
    • , Robert S. Fujinami
    •  & Mingnan Chen
  • Article |

    A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.

    • Girish D. Chitnis
    • , Mohan K. S. Verma
    • , Julien Lamazouade
    • , Miguel Gonzalez-Andrades
    • , Kisuk Yang
    • , Ali Dergham
    • , Peter Anthony Jones
    • , Benjamin E. Mead
    • , Andrea Cruzat
    • , Zhixiang Tong
    • , Keir Martyn
    • , Aniruddh Solanki
    • , Natalie Landon-Brace
    •  & Jeffrey M. Karp
  • Article |

    Intravenous delivery of an adenine base editor and a single-guide RNA for the Fah gene can correct an A>G splice-site mutation in an adult mouse model of tyrosinaemia.

    • Chun-Qing Song
    • , Tingting Jiang
    • , Michelle Richter
    • , Luke H. Rhym
    • , Luke W. Koblan
    • , Maria Paz Zafra
    • , Emma M. Schatoff
    • , Jordan L. Doman
    • , Yueying Cao
    • , Lukas E. Dow
    • , Lihua Julie Zhu
    • , Daniel G Anderson
    • , David R. Liu
    • , Hao Yin
    •  & Wen Xue
  • Article |

    Body-scale epidermal electronic interfaces for electrophysiological recordings enable the control of a transhumeral prosthesis, long-term electroencephalography, and simultaneous electroencephalography and structural and functional MRI.

    • Limei Tian
    • , Benjamin Zimmerman
    • , Aadeel Akhtar
    • , Ki Jun Yu
    • , Matthew Moore
    • , Jian Wu
    • , Ryan J. Larsen
    • , Jung Woo Lee
    • , Jinghua Li
    • , Yuhao Liu
    • , Brian Metzger
    • , Subing Qu
    • , Xiaogang Guo
    • , Kyle E. Mathewson
    • , Jonathan A. Fan
    • , Jesse Cornman
    • , Michael Fatina
    • , Zhaoqian Xie
    • , Yinji Ma
    • , Jue Zhang
    • , Yihui Zhang
    • , Florin Dolcos
    • , Monica Fabiani
    • , Gabriele Gratton
    • , Timothy Bretl
    • , Levi J. Hargrove
    • , Paul V. Braun
    • , Yonggang Huang
    •  & John A. Rogers
  • Article |

    A computationally designed molecular chaperone inhibits the interaction of normal prions with abnormal isoforms associated with transmissible spongiform encephalopathy, prolongs survival in infected mice and limits symptoms in infected macaques.

    • Keiichi Yamaguchi
    • , Yuji O. Kamatari
    • , Fumiko Ono
    • , Hiroaki Shibata
    • , Takayuki Fuse
    • , Abdelazim Elsayed Elhelaly
    • , Mayuko Fukuoka
    • , Tsutomu Kimura
    • , Junji Hosokawa-Muto
    • , Takeshi Ishikawa
    • , Minoru Tobiume
    • , Yoshinori Takeuchi
    • , Yutaka Matsuyama
    • , Daisuke Ishibashi
    • , Noriyuki Nishida
    •  & Kazuo Kuwata
  • Article |

    Genome-edited human pluripotent stem cells and genome-edited mouse models reveal that combinatorial genetic interactions contribute to the complex genetic heritability of human cardiomyopathy.

    • Dekker C. Deacon
    • , Cassandra L. Happe
    • , Chao Chen
    • , Neil Tedeschi
    • , Ana Maria Manso
    • , Ting Li
    • , Nancy D. Dalton
    • , Qian Peng
    • , Elie N. Farah
    • , Yusu Gu
    • , Kevin P. Tenerelli
    • , Vivien D. Tran
    • , Ju Chen
    • , Kirk L. Peterson
    • , Nicholas J. Schork
    • , Eric D. Adler
    • , Adam J. Engler
    • , Robert S. Ross
    •  & Neil C. Chi
  • Article |

    Mechanical stress associated with cardiac fibrosis, modelled by a hydrogel with controllable stiffness, affects regulation of the phenotypes of human cardiomyocytes by a portion of the long noncoding RNA ANRIL.

    • Aditya Kumar
    • , Stephanie K. Thomas
    • , Kirsten C. Wong
    • , Valentina Lo Sardo
    • , Daniel S. Cheah
    • , Yang-Hsun Hou
    • , Jesse K. Placone
    • , Kevin P. Tenerelli
    • , William C. Ferguson
    • , Ali Torkamani
    • , Eric J. Topol
    • , Kristin K. Baldwin
    •  & Adam J. Engler
  • Article |

    An assay that thermophoretically profiles surface proteins from serum extracellular vesicles labelled with a panel of fluorescent aptamers detects and classifies patients according to cancer type and cancer stage.

    • Chao Liu
    • , Junxiang Zhao
    • , Fei Tian
    • , Lili Cai
    • , Wei Zhang
    • , Qiang Feng
    • , Jianqiao Chang
    • , Fangning Wan
    • , Yunjie Yang
    • , Bo Dai
    • , Yulong Cong
    • , Baoquan Ding
    • , Jiashu Sun
    •  & Weihong Tan
  • Article |

    Conductive and elastic hydrogel-based microelectronic arrays with high current-injection density and low interfacial impedance with tissue enable the localized low-voltage electrical stimulation of the sciatic nerve in live mice.

    • Yuxin Liu
    • , Jia Liu
    • , Shucheng Chen
    • , Ting Lei
    • , Yeongin Kim
    • , Simiao Niu
    • , Huiliang Wang
    • , Xiao Wang
    • , Amir M. Foudeh
    • , Jeffrey B.-H. Tok
    •  & Zhenan Bao
  • Article |

    A battery-free implantable pressure sensor made entirely of biodegradable materials and based on fringe-field capacitor technology can wirelessly measure arterial blood flow in live rats.

    • Clementine M. Boutry
    • , Levent Beker
    • , Yukitoshi Kaizawa
    • , Christopher Vassos
    • , Helen Tran
    • , Allison C. Hinckley
    • , Raphael Pfattner
    • , Simiao Niu
    • , Junheng Li
    • , Jean Claverie
    • , Zhen Wang
    • , James Chang
    • , Paige M. Fox
    •  & Zhenan Bao
  • Article |

    Solid stress generated by brain tumours can cause neurological dysfunction in patients, and this could be countered by administering lithium, according to magnetic resonance imaging of patient brains and mouse models of human brain tumours.

    • Giorgio Seano
    • , Hadi T. Nia
    • , Kyrre E. Emblem
    • , Meenal Datta
    • , Jun Ren
    • , Shanmugarajan Krishnan
    • , Jonas Kloepper
    • , Marco C. Pinho
    • , William W. Ho
    • , Mitrajit Ghosh
    • , Vasileios Askoxylakis
    • , Gino B. Ferraro
    • , Lars Riedemann
    • , Elizabeth R. Gerstner
    • , Tracy T. Batchelor
    • , Patrick Y. Wen
    • , Nancy U. Lin
    • , Alan J. Grodzinsky
    • , Dai Fukumura
    • , Peigen Huang
    • , James W. Baish
    • , Timothy P. Padera
    • , Lance L. Munn
    •  & Rakesh K. Jain
  • Article |

    A closed-loop and wireless 128-channel neuromodulation device enables electrical stimulation as well as artefact-free long-term recording of local field potentials in the brain of an untethered non-human primate.

    • Andy Zhou
    • , Samantha R. Santacruz
    • , Benjamin C. Johnson
    • , George Alexandrov
    • , Ali Moin
    • , Fred L. Burghardt
    • , Jan M. Rabaey
    • , Jose M. Carmena
    •  & Rikky Muller
  • Article |

    A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.

    • Linda Nocchi
    • , Nainika Roy
    • , Mariangela D’Attilia
    • , Rahul Dhandapani
    • , Mariano Maffei
    • , Andrei Traista
    • , Laura Castaldi
    • , Emerald Perlas
    • , Cora Hallie Chadick
    •  & Paul A. Heppenstall
  • Article |

    An interpretable deep-learning algorithm trained on a small dataset of computed-tomography scans of the head detects acute ICH and classifies the pathology subtypes, with a performance comparable to expert radiologists.

    • Hyunkwang Lee
    • , Sehyo Yune
    • , Mohammad Mansouri
    • , Myeongchan Kim
    • , Shahein H. Tajmir
    • , Claude E. Guerrier
    • , Sarah A. Ebert
    • , Stuart R. Pomerantz
    • , Javier M. Romero
    • , Shahmir Kamalian
    • , Ramon G. Gonzalez
    • , Michael H. Lev
    •  & Synho Do
  • Article |

    Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.

    • Nicholas L. Opie
    • , Sam E. John
    • , Gil S. Rind
    • , Stephen M. Ronayne
    • , Yan T. Wong
    • , Giulia Gerboni
    • , Peter E. Yoo
    • , Timothy J. H. Lovell
    • , Theodore C. M. Scordas
    • , Stefan L. Wilson
    • , Anthony Dornom
    • , Thomas Vale
    • , Terence J. O’Brien
    • , David B. Grayden
    • , Clive N. May
    •  & Thomas J. Oxley
  • Article |

    CRISPR–Cas9-mediated genome editing can be activated locally in vivo via an applied magnetic field, after complexation of magnetic nanoparticles with recombinant baculoviral vectors packaging the CRISPR–Cas9 machinery.

    • Haibao Zhu
    • , Linlin Zhang
    • , Sheng Tong
    • , Ciaran M. Lee
    • , Harshavardhan Deshmukh
    •  & Gang Bao
  • Article |

    DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.

    • Dawei Jiang
    • , Zhilei Ge
    • , Hyung-Jun Im
    • , Christopher G. England
    • , Dalong Ni
    • , Junjun Hou
    • , Luhao Zhang
    • , Christopher J. Kutyreff
    • , Yongjun Yan
    • , Yan Liu
    • , Steve Y. Cho
    • , Jonathan W. Engle
    • , Jiye Shi
    • , Peng Huang
    • , Chunhai Fan
    • , Hao Yan
    •  & Weibo Cai
  • Article |

    The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.

    • Quanyin Hu
    • , Wujin Sun
    • , Jinqiang Wang
    • , Huitong Ruan
    • , Xudong Zhang
    • , Yanqi Ye
    • , Song Shen
    • , Chao Wang
    • , Weiyue Lu
    • , Ke Cheng
    • , Gianpietro Dotti
    • , Joshua F. Zeidner
    • , Jun Wang
    •  & Zhen Gu
  • Article |

    A deep-learning algorithm can detect polyps in the colon in real time and with high sensitivity and specificity, according to validation studies with prospectively collected images and videos from colonoscopies performed in 1,138 patients.

    • Pu Wang
    • , Xiao Xiao
    • , Jeremy R. Glissen Brown
    • , Tyler M. Berzin
    • , Mengtian Tu
    • , Fei Xiong
    • , Xiao Hu
    • , Peixi Liu
    • , Yan Song
    • , Di Zhang
    • , Xue Yang
    • , Liangping Li
    • , Jiong He
    • , Xin Yi
    • , Jingjia Liu
    •  & Xiaogang Liu
  • Article |

    The combination of mathematical modelling of tumour tissue, optical imaging of cleared tumours from animal models, and in vivo imaging of vascular perfusion in tumours predicts the tumour uptake and distribution of specific therapeutic agents.

    • Angela d’Esposito
    • , Paul W. Sweeney
    • , Morium Ali
    • , Magdy Saleh
    • , Rajiv Ramasawmy
    • , Thomas A. Roberts
    • , Giulia Agliardi
    • , Adrien Desjardins
    • , Mark F. Lythgoe
    • , R. Barbara Pedley
    • , Rebecca Shipley
    •  & Simon Walker-Samuel
  • Article |

    An alert system based on machine learning and trained on surgical data from electronic medical records helps anaesthesiologists prevent hypoxaemia during surgery by providing interpretable real-time predictions.

    • Scott M. Lundberg
    • , Bala Nair
    • , Monica S. Vavilala
    • , Mayumi Horibe
    • , Michael J. Eisses
    • , Trevor Adams
    • , David E. Liston
    • , Daniel King-Wai Low
    • , Shu-Fang Newman
    • , Jerry Kim
    •  & Su-In Lee
  • Article |

    Bioresorbable pressure sensors with significantly improved operational lifetimes, as exemplified via the monitoring of intracranial pressure in rats for over 25 days, can be similarly accurate to analogous non-resorbable clinical devices.

    • Jiho Shin
    • , Ying Yan
    • , Wubin Bai
    • , Yeguang Xue
    • , Paul Gamble
    • , Limei Tian
    • , Irawati Kandela
    • , Chad R. Haney
    • , William Spees
    • , Yechan Lee
    • , Minseok Choi
    • , Jonathan Ko
    • , Hangyu Ryu
    • , Jan-Kai Chang
    • , Maryam Pezhouh
    • , Seung-Kyun Kang
    • , Sang Min Won
    • , Ki Jun Yu
    • , Jianing Zhao
    • , Yoon Kyeung Lee
    • , Matthew R. MacEwan
    • , Sheng-Kwei Song
    • , Yonggang Huang
    • , Wilson Z. Ray
    •  & John A. Rogers
  • Article |

    The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.

    • Mohammad Ariful Islam
    • , Yingjie Xu
    • , Wei Tao
    • , Jessalyn M. Ubellacker
    • , Michael Lim
    • , Daniel Aum
    • , Gha Young Lee
    • , Kun Zhou
    • , Harshal Zope
    • , Mikyung Yu
    • , Wuji Cao
    • , James Trevor Oswald
    • , Meshkat Dinarvand
    • , Morteza Mahmoudi
    • , Robert Langer
    • , Philip W. Kantoff
    • , Omid C. Farokhzad
    • , Bruce R. Zetter
    •  & Jinjun Shi
  • Article |

    An assay that uses machine-learning algorithms on phenotypic-biomarker data from live primary cells predicts post-surgical adverse pathology in prostate-cancer and breast cancer tissue samples from patients.

    • Michael S. Manak
    • , Jonathan S. Varsanik
    • , Brad J. Hogan
    • , Matt J. Whitfield
    • , Wendell R. Su
    • , Nikhil Joshi
    • , Nicolai Steinke
    • , Andrew Min
    • , Delaney Berger
    • , Robert J. Saphirstein
    • , Gauri Dixit
    • , Thiagarajan Meyyappan
    • , Hui-May Chu
    • , Kevin B. Knopf
    • , David M. Albala
    • , Grannum R. Sant
    •  & Ashok C. Chander
  • Article |

    A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.

    • Ryan Snodgrass
    • , Andrea Gardner
    • , Aggrey Semeere
    • , Varun Lingaiah Kopparthy
    • , Jens Duru
    • , Toby Maurer
    • , Jeffrey Martin
    • , Ethel Cesarman
    •  & David Erickson
  • Article |

    An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.

    • Chonghe Wang
    • , Xiaoshi Li
    • , Hongjie Hu
    • , Lin Zhang
    • , Zhenlong Huang
    • , Muyang Lin
    • , Zhuorui Zhang
    • , Zhenan Yin
    • , Brady Huang
    • , Hua Gong
    • , Shubha Bhaskaran
    • , Yue Gu
    • , Mitsutoshi Makihata
    • , Yuxuan Guo
    • , Yusheng Lei
    • , Yimu Chen
    • , Chunfeng Wang
    • , Yang Li
    • , Tianjiao Zhang
    • , Zeyu Chen
    • , Albert P. Pisano
    • , Liangfang Zhang
    • , Qifa Zhou
    •  & Sheng Xu
  • Article |

    Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.

    • Zhen Ma
    • , Nathaniel Huebsch
    • , Sangmo Koo
    • , Mohammad A. Mandegar
    • , Brian Siemons
    • , Steven Boggess
    • , Bruce R. Conklin
    • , Costas P. Grigoropoulos
    •  & Kevin E. Healy