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  • Article |

    An integrated system consisting of conformable piezoelectric devices, three-dimensional digital image correlation, multiphysics modelling and real-time classification algorithms predicts facial kinematics and decodes facial deformations.

    • Tao Sun
    • , Farita Tasnim
    • , Rachel T. McIntosh
    • , Nikta Amiri
    • , Dana Solav
    • , Mostafa Tavakkoli Anbarani
    • , David Sadat
    • , Lin Zhang
    • , Yuandong Gu
    • , M. Amin Karami
    •  & Canan Dagdeviren
  • Article |

    Two clinically relevant subtypes of post-traumatic stress disorder and major depressive disorder have been identified via machine learning analyses of functional connectivity patterns in resting-state electroencephalography.

    • Yu Zhang
    • , Wei Wu
    • , Russell T. Toll
    • , Sharon Naparstek
    • , Adi Maron-Katz
    • , Mallissa Watts
    • , Joseph Gordon
    • , Jisoo Jeong
    • , Laura Astolfi
    • , Emmanuel Shpigel
    • , Parker Longwell
    • , Kamron Sarhadi
    • , Dawlat El-Said
    • , Yuanqing Li
    • , Crystal Cooper
    • , Cherise Chin-Fatt
    • , Martijn Arns
    • , Madeleine S. Goodkind
    • , Madhukar H. Trivedi
    • , Charles R. Marmar
    •  & Amit Etkin
  • Article |

    Deep-learning models for the automated measurement of retinal-vessel calibre in retinal photographs perform comparably to or better than expert graders in associations of measurements of retinal-vessel calibre with cardiovascular risk factors.

    • Carol Y. Cheung
    • , Dejiang Xu
    • , Ching-Yu Cheng
    • , Charumathi Sabanayagam
    • , Yih-Chung Tham
    • , Marco Yu
    • , Tyler Hyungtaek Rim
    • , Chew Yian Chai
    • , Bamini Gopinath
    • , Paul Mitchell
    • , Richie Poulton
    • , Terrie E. Moffitt
    • , Avshalom Caspi
    • , Jason C. Yam
    • , Clement C. Tham
    • , Jost B. Jonas
    • , Ya Xing Wang
    • , Su Jeong Song
    • , Louise M. Burrell
    • , Omar Farouque
    • , Ling Jun Li
    • , Gavin Tan
    • , Daniel S. W. Ting
    • , Wynne Hsu
    • , Mong Li Lee
    •  & Tien Y. Wong
  • Article |

    The sustained release of a leukaemia-associated epitope peptide and of anti-PD-1 antibody co-encapsulated in degradable microcapsules results in superior therapeutic outcomes in mouse models of leukaemia.

    • Xiaoling Xie
    • , Yuxing Hu
    • , Tong Ye
    • , Yiran Chen
    • , Lijuan Zhou
    • , Feng Li
    • , Xiaobo Xi
    • , Shuang Wang
    • , Yanjie He
    • , Xiaoyong Gao
    • , Wei Wei
    • , Guanghui Ma
    •  & Yuhua Li
  • Article |

    The enhanced accumulation and residence time of systemically administered interleukin-4 fused to serum albumin in lymph nodes and in the spleen prevents the development of multiple sclerosis in mice.

    • Ako Ishihara
    • , Jun Ishihara
    • , Elyse A. Watkins
    • , Andrew C. Tremain
    • , Mindy Nguyen
    • , Ani Solanki
    • , Kiyomitsu Katsumata
    • , Aslan Mansurov
    • , Erica Budina
    • , Aaron T. Alpar
    • , Peyman Hosseinchi
    • , Lea Maillat
    • , Joseph W. Reda
    • , Takahiro Kageyama
    • , Melody A. Swartz
    • , Eiji Yuba
    •  & Jeffrey A. Hubbell
  • Article |

    Systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA for silencing genes in bone-marrow endothelial cells of mice improved the healing of the mice after myocardial infarction.

    • Marvin Krohn-Grimberghe
    • , Michael J. Mitchell
    • , Maximilian J. Schloss
    • , Omar F. Khan
    • , Gabriel Courties
    • , Pedro P. G. Guimaraes
    • , David Rohde
    • , Sebastian Cremer
    • , Piotr S. Kowalski
    • , Yuan Sun
    • , Mingchee Tan
    • , Jamie Webster
    • , Karin Wang
    • , Yoshiko Iwamoto
    • , Stephen P. Schmidt
    • , Gregory R. Wojtkiewicz
    • , Ribhu Nayar
    • , Vanessa Frodermann
    • , Maarten Hulsmans
    • , Amanda Chung
    • , Friedrich Felix Hoyer
    • , Filip K. Swirski
    • , Robert Langer
    • , Daniel G. Anderson
    •  & Matthias Nahrendorf
  • Article
    | Open Access

    An open-source integrated knee–ankle robotic prosthesis facilitates the testing of control strategies and biomechanics in real-world environments.

    • Alejandro F. Azocar
    • , Luke M. Mooney
    • , Jean-François Duval
    • , Ann M. Simon
    • , Levi J. Hargrove
    •  & Elliott J. Rouse
  • Article |

    A web tool enables the rapid design of prime-editing guide RNAs from reference and edited DNA sequences, for diverse prime-editing applications.

    • Ryan D. Chow
    • , Jennifer S. Chen
    • , Johanna Shen
    •  & Sidi Chen
  • Article |

    Optical contrast agents using AND-gate logic enhance the specificity and sensitivity of fluorescence-guided imaging in the resection of tumours and in the detection of metastases in mouse models of cancer.

    • John C. Widen
    • , Martina Tholen
    • , Joshua J. Yim
    • , Alexander Antaris
    • , Kerriann M. Casey
    • , Stephan Rogalla
    • , Alwin Klaassen
    • , Jonathan Sorger
    •  & Matthew Bogyo
  • Article |

    A microfluidic assay that quantifies cell migration and proliferation can prospectively categorize patients with glioblastoma according to progression-free survival.

    • Bin Sheng Wong
    • , Sagar R. Shah
    • , Christopher L. Yankaskas
    • , Vivek K. Bajpai
    • , Pei-Hsun Wu
    • , Deborah Chin
    • , Brent Ifemembi
    • , Karim ReFaey
    • , Paula Schiapparelli
    • , Xiaobin Zheng
    • , Stuart S. Martin
    • , Chen-Ming Fan
    • , Alfredo Quiñones-Hinojosa
    •  & Konstantinos Konstantopoulos
  • Article |

    An intravenously administered electric-field-sensitive contrast agent for magnetic resonance imaging that crosses the blood–brain barrier improves lesion visualization with high sensitivity and target-to-background ratio in mice.

    • Cong Wang
    • , Wanbing Sun
    • , Jun Zhang
    • , Jianping Zhang
    • , Qinghua Guo
    • , Xingyu Zhou
    • , Dandan Fan
    • , Haoran Liu
    • , Ming Qi
    • , Xihui Gao
    • , Haiyan Xu
    • , Zhaobing Gao
    • , Mei Tian
    • , Hong Zhang
    • , Jianhong Wang
    • , Zixuan Wei
    • , Nicholas J. Long
    • , Ying Mao
    •  & Cong Li
  • Article |

    Pigs can be genetically modified to inactivate endogenous retroviruses and to display enhanced compatibility with the human immune system using a combination of CRISPR–Cas9 and transposon technologies.

    • Yanan Yue
    • , Weihong Xu
    • , Yinan Kan
    • , Hong-Ye Zhao
    • , Yixuan Zhou
    • , Xiaobin Song
    • , Jiajia Wu
    • , Juan Xiong
    • , Dharmendra Goswami
    • , Meng Yang
    • , Lydia Lamriben
    • , Mengyuan Xu
    • , Qi Zhang
    • , Yu Luo
    • , Jianxiong Guo
    • , Shengyi Mao
    • , Deling Jiao
    • , Tien Dat Nguyen
    • , Zhuo Li
    • , Jacob V. Layer
    • , Mailin Li
    • , Violette Paragas
    • , Michele E. Youd
    • , Zhongquan Sun
    • , Yuan Ding
    • , Weilin Wang
    • , Hongwei Dou
    • , Lingling Song
    • , Xueqiong Wang
    • , Lei Le
    • , Xin Fang
    • , Haydy George
    • , Ranjith Anand
    • , Shi Yun Wang
    • , William F. Westlin
    • , Marc Güell
    • , James Markmann
    • , Wenning Qin
    • , Yangbin Gao
    • , Hong-Jiang Wei
    • , George M. Church
    •  & Luhan Yang
  • Article |

    Customized soft electrode arrays that are well adjusted to specific anatomical environments, functions and experimental models can be rapidly prototyped via the robotically controlled deposition of conductive inks and insulating inks.

    • Dzmitry Afanasenkau
    • , Daria Kalinina
    • , Vsevolod Lyakhovetskii
    • , Christoph Tondera
    • , Oleg Gorsky
    • , Seyyed Moosavi
    • , Natalia Pavlova
    • , Natalia Merkulyeva
    • , Allan V. Kalueff
    • , Ivan R. Minev
    •  & Pavel Musienko
  • Article |

    A multiplexed fluorescence-based assay detects seroconversion in individuals infected with SARS-CoV-2 from less than 1 µl of blood as early as the day of the first positive nasopharyngeal nucleic acid test after symptom onset.

    • Maia Norman
    • , Tal Gilboa
    • , Alana F. Ogata
    • , Adam M. Maley
    • , Limor Cohen
    • , Evan L. Busch
    • , Roey Lazarovits
    • , Chih-Ping Mao
    • , Yongfei Cai
    • , Jun Zhang
    • , Jared E. Feldman
    • , Blake M. Hauser
    • , Timothy M. Caradonna
    • , Bing Chen
    • , Aaron G. Schmidt
    • , Galit Alter
    • , Richelle C. Charles
    • , Edward T. Ryan
    •  & David R. Walt
  • Article |

    Molecular and physiological phenotypes in mouse models of myotonic dystrophy type I can be sustainably reversed by CRISPR-mediated targeting of toxic RNA repeats.

    • Ranjan Batra
    • , David A. Nelles
    • , Daniela M. Roth
    • , Florian Krach
    • , Curtis A. Nutter
    • , Takahiro Tadokoro
    • , James D. Thomas
    • , Łukasz J. Sznajder
    • , Steven M. Blue
    • , Haydee L. Gutierrez
    • , Patrick Liu
    • , Stefan Aigner
    • , Oleksandr Platoshyn
    • , Atsushi Miyanohara
    • , Martin Marsala
    • , Maurice S. Swanson
    •  & Gene W. Yeo
  • Article |

    A gelling hypotonic solution for ocular delivery that forms a uniform and clear thin layer conformal to the ocular surface resists clearance from blinking and extends the residence time of the delivered drugs.

    • Yoo Chun Kim
    • , Matthew D. Shin
    • , Sean F. Hackett
    • , Henry T. Hsueh
    • , Raquel Lima e Silva
    • , Abhijit Date
    • , Hyounkoo Han
    • , Byung-Jin Kim
    • , Amy Xiao
    • , Youngwook Kim
    • , Laolu Ogunnaike
    • , Nicole M. Anders
    • , Avelina Hemingway
    • , Ping He
    • , Albert S. Jun
    • , Peter J. McDonnell
    • , Charles Eberhart
    • , Ian Pitha
    • , Donald J. Zack
    • , Peter A. Campochiaro
    • , Justin Hanes
    •  & Laura M. Ensign
  • Article |

    Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts.

    • Mengdi Han
    • , Lin Chen
    • , Kedar Aras
    • , Cunman Liang
    • , Xuexian Chen
    • , Hangbo Zhao
    • , Kan Li
    • , Ndeye Rokhaya Faye
    • , Bohan Sun
    • , Jae-Hwan Kim
    • , Wubin Bai
    • , Quansan Yang
    • , Yuhang Ma
    • , Wei Lu
    • , Enming Song
    • , Janice Mihyun Baek
    • , Yujin Lee
    • , Clifford Liu
    • , Jeffrey B. Model
    • , Guanjun Yang
    • , Roozbeh Ghaffari
    • , Yonggang Huang
    • , Igor R. Efimov
    •  & John A. Rogers
  • Article |

    The specific high-sensitivity enzymatic reporter unlocking (SHERLOCK) assay detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA with high sensitivity and specificity in hundreds of nasopharyngeal and throat swab samples collected at Siriraj Hospital in Thailand.

    • Maturada Patchsung
    • , Krittapas Jantarug
    • , Archiraya Pattama
    • , Kanokpol Aphicho
    • , Surased Suraritdechachai
    • , Piyachat Meesawat
    • , Khomkrit Sappakhaw
    • , Nattawat Leelahakorn
    • , Theerawat Ruenkam
    • , Thanakrit Wongsatit
    • , Niracha Athipanyasilp
    • , Bhumrapee Eiamthong
    • , Benya Lakkanasirorat
    • , Thitima Phoodokmai
    • , Nootaree Niljianskul
    • , Danaya Pakotiprapha
    • , Sittinan Chanarat
    • , Aimorn Homchan
    • , Ruchanok Tinikul
    • , Philaiwarong Kamutira
    • , Kochakorn Phiwkaow
    • , Sahachat Soithongcharoen
    • , Chadaporn Kantiwiriyawanitch
    • , Vinutsada Pongsupasa
    • , Duangthip Trisrivirat
    • , Juthamas Jaroensuk
    • , Thanyaporn Wongnate
    • , Somchart Maenpuen
    • , Pimchai Chaiyen
    • , Sirichai Kamnerdnakta
    • , Jirawat Swangsri
    • , Suebwong Chuthapisith
    • , Yongyut Sirivatanauksorn
    • , Chutikarn Chaimayo
    • , Ruengpung Sutthent
    • , Wannee Kantakamalakul
    • , Julia Joung
    • , Alim Ladha
    • , Xin Jin
    • , Jonathan S. Gootenberg
    • , Omar O. Abudayyeh
    • , Feng Zhang
    • , Navin Horthongkham
    •  & Chayasith Uttamapinant
  • Article |

    Intratumoural injection of a self-assembling supramolecular hydrogel that slowly releases a STING agonist and a chemotherapeutic agent reduces tumour immunosuppression and increases antitumour responses in mice.

    • Feihu Wang
    • , Hao Su
    • , Dongqing Xu
    • , Wenbing Dai
    • , Weijie Zhang
    • , Zongyuan Wang
    • , Caleb F. Anderson
    • , Mengzhen Zheng
    • , Richard Oh
    • , Fengyi Wan
    •  & Honggang Cui
  • Article |

    Analyses of data from intracortical brain–computer interfaces implanted in rhesus macaques and in a human suggest that the circuit design parameters of current recording interfaces can be relaxed considerably without loss of performance.

    • Nir Even-Chen
    • , Dante G. Muratore
    • , Sergey D. Stavisky
    • , Leigh R. Hochberg
    • , Jaimie M. Henderson
    • , Boris Murmann
    •  & Krishna V. Shenoy
  • Article |

    Post-mortem histopathological data can be used to classify neuropathologies into six transdiagnostic clusters, and patient membership to these clusters can be predicted from cognitive scores, genotype and protein levels in cerebrospinal fluid.

    • Eli J. Cornblath
    • , John L. Robinson
    • , David J. Irwin
    • , Edward B. Lee
    • , Virginia M.-Y. Lee
    • , John Q. Trojanowski
    •  & Danielle S. Bassett
  • Article |

    An antibody-discovery pipeline integrating single-cell mRNA-sequence analysis, bioinformatics, synthetic biology and high-throughput functional analyses enables the rapid discovery of potent human monoclonal antibodies against viral pathogens.

    • Pavlo Gilchuk
    • , Robin G. Bombardi
    • , Jesse H. Erasmus
    • , Qing Tan
    • , Rachel Nargi
    • , Cinque Soto
    • , Peter Abbink
    • , Todd J. Suscovich
    • , Lorellin A. Durnell
    • , Amit Khandhar
    • , Jacob Archer
    • , Jenny Liang
    • , Mallorie E. Fouch
    • , Edgar Davidson
    • , Benjamin J. Doranz
    • , Taylor Jones
    • , Elise Larson
    • , Stacey Ertel
    • , Brian Granger
    • , Jasmine Fuerte-Stone
    • , Vicky Roy
    • , Thomas Broge
    • , Thomas C. Linnekin
    • , Caitlyn H. Linde
    • , Matthew J. Gorman
    • , Joseph Nkolola
    • , Galit Alter
    • , Steven G. Reed
    • , Dan H. Barouch
    • , Michael S. Diamond
    • , James E. Crowe Jr
    • , Neal Van Hoeven
    • , Larissa B. Thackray
    •  & Robert H. Carnahan
  • Article |

    T cells can be classified according to their activation state and subtype on the basis of their autofluorescence lifetime patterns.

    • Alex J. Walsh
    • , Katherine P. Mueller
    • , Kelsey Tweed
    • , Isabel Jones
    • , Christine M. Walsh
    • , Nicole J. Piscopo
    • , Natalie M. Niemi
    • , David J. Pagliarini
    • , Krishanu Saha
    •  & Melissa C. Skala
  • Article |

    The 300–1,000 Hz band of spiking activity, dominated by local single-unit spikes, can enhance the decoding performance of neural interfaces.

    • Samuel R. Nason
    • , Alex K. Vaskov
    • , Matthew S. Willsey
    • , Elissa J. Welle
    • , Hyochan An
    • , Philip P. Vu
    • , Autumn J. Bullard
    • , Chrono S. Nu
    • , Jonathan C. Kao
    • , Krishna V. Shenoy
    • , Taekwang Jang
    • , Hun-Seok Kim
    • , David Blaauw
    • , Parag G. Patil
    •  & Cynthia A. Chestek
  • Article |

    The expression of therapeutic protein targets in circulating tumour cells isolated from blood samples of patients with cancer can be tracked at the single-cell level by antibody-mediated magnetic labelling and microfluidic sorting.

    • Mahmoud Labib
    • , Zongjie Wang
    • , Sharif U. Ahmed
    • , Reza M. Mohamadi
    • , Bill Duong
    • , Brenda Green
    • , Edward H. Sargent
    •  & Shana O. Kelley
  • Article |

    An integrative strategy based on mass spectrometry for the phosphoproteomic profiling of normal and fibrotic cardiac tissue from diverse sources identifies key signalling pathways involved in cardiac fibrosis.

    • Uros Kuzmanov
    • , Erika Yan Wang
    • , Rachel Vanderlaan
    • , Da Hye Kim
    • , Shin-Haw Lee
    • , Sina Hadipour-Lakmehsari
    • , Hongbo Guo
    • , Yimu Zhao
    • , Meghan McFadden
    • , Parveen Sharma
    • , Filio Billia
    • , Milica Radisic
    • , Anthony Gramolini
    •  & Andrew Emili
  • Article |

    Renally clearable gold quantum clusters that are stabilized by the milk metalloprotein alpha-lactalbumin and display multicolour fluorescence aid the detection, resection and treatment of breast cancer in mice.

    • Jiang Yang
    • , Tai Wang
    • , Lina Zhao
    • , Vinagolu K. Rajasekhar
    • , Suhasini Joshi
    • , Chrysafis Andreou
    • , Suchetan Pal
    • , Hsiao-ting Hsu
    • , Hanwen Zhang
    • , Ivan J. Cohen
    • , Ruimin Huang
    • , Ronald C. Hendrickson
    • , Matthew M. Miele
    • , Wenbo Pei
    • , Matthew B. Brendel
    • , John H. Healey
    • , Gabriela Chiosis
    •  & Moritz F. Kircher
  • Article |

    Methotrexate-loaded tumour-cell-derived microvesicles induce neutrophil-mediated antitumour activity and can relieve biliary obstructions in patients with extrahepatic cholangiocarcinoma.

    • Yunfeng Gao
    • , Hui Zhang
    • , Nannan Zhou
    • , Pingwei Xu
    • , Jianxiong Wang
    • , Yuan Gao
    • , Xun Jin
    • , Xiaoyu Liang
    • , Jiadi Lv
    • , Yamin Zhang
    • , Ke Tang
    • , Jingwei Ma
    • , Huafeng Zhang
    • , Jing Xie
    • , Fang Yao
    • , Weimin Tong
    • , Yuying Liu
    • , Ximo Wang
    •  & Bo Huang
  • Article |

    Cell-laden hydrogels can be patterned with algorithmically generated sacrificial dendritic vessel networks made of laser-sintered carbohydrate powders.

    • Ian S. Kinstlinger
    • , Sarah H. Saxton
    • , Gisele A. Calderon
    • , Karen Vasquez Ruiz
    • , David R. Yalacki
    • , Palvasha R. Deme
    • , Jessica E. Rosenkrantz
    • , Jesse D. Louis-Rosenberg
    • , Fredrik Johansson
    • , Kevin D. Janson
    • , Daniel W. Sazer
    • , Saarang S. Panchavati
    • , Karl-Dimiter Bissig
    • , Kelly R. Stevens
    •  & Jordan S. Miller
  • Article |

    A method for the multimodal volumetric imaging of RNAs and proteins in intact tumour volumes and organoids enables the spatial transcriptional profiling of coding RNAs and non-coding RNAs at single-cell resolution in cancer tissues.

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Dagmara Kaczynska
    • , Keishiro Fukumoto
    • , Lauri Louhivuori
    • , Tomohiro Mizutani
    • , Oded Kopper
    • , Pauliina Kronqvist
    • , Stephanie Robertson
    • , Claes Lindh
    • , Lorand Kis
    • , Robin Pronk
    • , Naoya Niwa
    • , Kazuhiro Matsumoto
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Anna Falk
    • , Johan Hartman
    • , Cecilia Sahlgren
    • , Hans Clevers
    •  & Per Uhlén
  • Article |

    Label-free imaging of the endogenous pigment lipofuscin at near-infrared and shortwave-infrared wavelengths enables the longitudinal monitoring of liver injury in mice and in biopsied human livers.

    • Mari Saif
    • , Wilhelmus J. Kwanten
    • , Jessica A. Carr
    • , Ivy X. Chen
    • , Jessica M. Posada
    • , Amitabh Srivastava
    • , Juanye Zhang
    • , Yi Zheng
    • , Matthias Pinter
    • , Sampurna Chatterjee
    • , Samir Softic
    • , C. Ronald Kahn
    • , Klaus van Leyen
    • , Oliver T. Bruns
    • , Rakesh K. Jain
    •  & Moungi G. Bawendi
  • Article |

    A workflow that segments anatomical structures in slit-lamp images and that annotates pathological features in each image improves the performance of a deep-learning algorithm for the diagnosis of ophthalmic disorders.

    • Wangting Li
    • , Yahan Yang
    • , Kai Zhang
    • , Erping Long
    • , Lin He
    • , Lei Zhang
    • , Yi Zhu
    • , Chuan Chen
    • , Zhenzhen Liu
    • , Xiaohang Wu
    • , Dongyuan Yun
    • , Jian Lv
    • , Yizhi Liu
    • , Xiyang Liu
    •  & Haotian Lin
  • Article |

    Three-dimensional cell-laden photosensitive polymer hydrogels can be bioprinted in tissues of live animals, by bio-orthogonal two-photon cycloaddition and crosslinking of the polymers.

    • Anna Urciuolo
    • , Ilaria Poli
    • , Luca Brandolino
    • , Paolo Raffa
    • , Valentina Scattolini
    • , Cecilia Laterza
    • , Giovanni G. Giobbe
    • , Elisa Zambaiti
    • , Giulia Selmin
    • , Michael Magnussen
    • , Laura Brigo
    • , Paolo De Coppi
    • , Stefano Salmaso
    • , Monica Giomo
    •  & Nicola Elvassore
  • Article |

    The combination of tumour-infarction therapy and chemotherapy, delivered via nanoparticles decorated with a tumour-homing peptide and encapsulating thrombin and doxorubicin, outperforms the corresponding monotherapies in tumour-bearing mice and rabbits.

    • Suping Li
    • , Yinlong Zhang
    • , Shih-Hsin Ho
    • , Bozhao Li
    • , Meifang Wang
    • , Xiongwei Deng
    • , Na Yang
    • , Guangna Liu
    • , Zefang Lu
    • , Junchao Xu
    • , Quanwei Shi
    • , Jing-Yan Han
    • , Lirong Zhang
    • , Yan Wu
    • , Yuliang Zhao
    •  & Guangjun Nie
  • Article |

    The travelling kinetics of single cells loaded with mesoporous silica nanoparticles concentrating the 68Ga radioisotope can be tracked in real time in vivo from the patterns of coincident gamma rays detected by positron emission tomography.

    • Kyung Oh Jung
    • , Tae Jin Kim
    • , Jung Ho Yu
    • , Siyeon Rhee
    • , Wei Zhao
    • , Byunghang Ha
    • , Kristy Red-Horse
    • , Sanjiv Sam Gambhir
    •  & Guillem Pratx
  • Article |

    Thousands of individual gastrointestinal organoids cultured on microcavity arrays without a solid extracellular matrix allow for high-throughput drug screening and for high-content image-based phenotypic analyses.

    • Nathalie Brandenberg
    • , Sylke Hoehnel
    • , Fabien Kuttler
    • , Krisztian Homicsko
    • , Camilla Ceroni
    • , Till Ringel
    • , Nikolce Gjorevski
    • , Gerald Schwank
    • , George Coukos
    • , Gerardo Turcatti
    •  & Matthias P. Lutolf
  • Article |

    Buckling kirigami structures applied to footwear outsoles generate higher friction forces transversally to the direction of movement.

    • Sahab Babaee
    • , Simo Pajovic
    • , Ahmad Rafsanjani
    • , Yichao Shi
    • , Katia Bertoldi
    •  & Giovanni Traverso
  • Article |

    A custom-made fidget spinner rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification.

    • Issac Michael
    • , Dongyoung Kim
    • , Oleksandra Gulenko
    • , Sumit Kumar
    • , Saravana Kumar
    • , Jothi Clara
    • , Dong Yeob Ki
    • , Juhee Park
    • , Hyun Yong Jeong
    • , Taek Soo Kim
    • , Sunghoon Kwon
    •  & Yoon-Kyoung Cho
  • Article |

    The co-administration of insulin and pramlintide stabilized with cucurbit[7]uril-conjugated polyethylene glycol in diabetic pigs improves the mealtime suppression of glucagon over the separate administration of the two hormones.

    • Caitlin L. Maikawa
    • , Anton A. A. Smith
    • , Lei Zou
    • , Gillie A. Roth
    • , Emily C. Gale
    • , Lyndsay M. Stapleton
    • , Sam W. Baker
    • , Joseph L. Mann
    • , Anthony C. Yu
    • , Santiago Correa
    • , Abigail K. Grosskopf
    • , Celine S. Liong
    • , Catherine M. Meis
    • , Doreen Chan
    • , Megan Troxell
    • , David M. Maahs
    • , Bruce A. Buckingham
    • , Matthew J. Webber
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    A robotically handled culture system using porcine gastrointestinal tissue explants for the high-throughput interrogation of the gastrointestinal tract predicts the absorption of oral drugs in the human gut better than Caco-2 Transwells.

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    • , Sarah Saxton
    • , Yunhua Shi
    • , Daniel Minahan
    • , Daniel Reker
    • , Farhad Javid
    • , Young-Ah Lucy Lee
    • , Carl Schoellhammer
    • , Tina Esfandiary
    • , Cody Cleveland
    • , Lucas Booth
    • , Jiaqi Lin
    • , Hannah Levy
    • , Sophie Blackburn
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso