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This Review Article provides an overview of chimeric antigen receptors (CARs) for T cells and discusses engineering strategies for the design of next-generation CAR-T therapies for haematologic and solid cancers.
This Review discusses technology for the isolation and phenotypic profiling of circulating tumour cells from blood for the identification of those with high metastatic potential as well as requirements for clinical applications of the cells.
This Review discusses the role of glia as an effector of the performance and integration of devices implanted in the brain, and the implications of this for device development.
This Review discusses imaging approaches that benefit from the combination of signals and modalities to enhance patient diagnosis and the monitoring of therapy.
This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.
This Review provides a broad account of the applications of light in imaging, diagnosis, therapy and surgery, and discusses the promise of emerging light-based technologies.
