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The growth of aortic aneurysms can be predicted via a dimensionless physiomarker, derived from first principles and calculated from data acquired via 4D flow magnetic resonance imaging, that describes a transition from stable blood flow to unstable aortic fluttering.
The composition of lipid nanoparticles for the delivery of tumour-antigen-encoding mRNA can be optimized via a screening method to enhance antitumour activity via the modulation of the immune activity of helper T cells.
Linear mathematical models derived from measurements of local field potentials and of whole-brain blood-oxygen-level-dependent neural activity predict resting-state neural dynamics at least as accurately as nonlinear models.
Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.
A wide-field fluorescence microscope leveraging a spinning disc and high-speed cameras enables the recording of neural activities and neutrophil trajectories at micrometric resolution on curved cortical surfaces in live mice.
Optimized base editors targeting the exon-7 mutation in SMN2 restore expression of the survival motor neuron (SMN) protein to normal levels, as shown in mice with spinal muscular atrophy and in fibroblasts from patients with this genetic disease.
A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.
The transplantation and long-term survival of hydrogel-encapsulated islets can be enhanced by first using a catheter to create a subcutaneous cavity and to trigger inflammation-induced local neovascularization.
A subcutaneous colon-specific niche consisting of colon epithelial cells, decellularized colon extracellular matrix and immunosuppressive nanofibres reduced inflammation in the gastrointestinal tract of mice with established ulcerative colitis.
Skin-microangiopathy phenotypes can be correlated with diabetes stage by leveraging clinically explainable morphophysiological features obtained from the analysis, via machine learning, of raster-scan optoacoustic mesoscopy images of skin on the leg.
Photoacoustic tomography using a single laser pulse and a single element functioning as thousands of virtual detectors allows for the volumetric capture of fast haemodynamic changes in the feet of human volunteers.
Barcoding individual cells with microparticles emitting near-infrared laser light enables the use of flow cytometry for the measurement of time-resolved single-cell dynamics with more markers and fewer colours.
Replacing the extracellular domains of heterodimeric cytokine receptors in chimeric antigen receptor T cells with two leucine zipper motifs leads to optimal JAK/STAT signalling and augments the effector function of the T cells.
Successive single-shot wide-field photoacoustic images can be used to estimate the speed and direction of blood flow at more than 5 mm deep from the skin’s surface.
Metabolic rewiring during tachycardia promotes tissue hypoxia, elevated glucose utilization and the suppression of oxidative phosphorylation, driving contractile dysfunction.
The immunization of mice with colitis with self-assembling supramolecular peptide nanofibres bearing phosphorylcholine epitopes induced sustained levels of anti-phosphorylcholine antibodies that were both protective and therapeutic.
A high-throughput microfluidic method for the analysis of the secretion levels of large populations of immune cells allows for the identification of kinase-coding genes regulating interferon-gamma secretion by CD4+ T cells.
Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting domains and fusogenic glycoproteins.
Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.
The overexpression of eight immunomodulatory transgenes in mouse embryonic stem cells allows these immunologically ‘cloaked’ cells as well as tissues derived from them to escape rejection and to survive for months in immunocompetent allogeneic recipients.