Browse Articles

  • Article |

    A compact, self-contained device bearing an array of microneedles collects 100 μl of blood at the push of a button, and is more convenient and less painful than a fingerstick and venepuncture.

    • Timothy M. Blicharz
    • , Ping Gong
    • , Bernard M. Bunner
    • , Larry L. Chu
    • , Kaela M. Leonard
    • , Jessica A. Wakefield
    • , Richard E. Williams
    • , Maisam Dadgar
    • , Carlo A. Tagliabue
    • , Ragheb El Khaja
    • , Stephanie L. Marlin
    • , Ramin Haghgooie
    • , Shawn P. Davis
    • , Donald E. Chickering
    •  & Howard Bernstein
  • Article |

    The slow release of pro-survival peptide analogues crosslinked to an injectable collagen–dendrimer biomaterial significantly prolongs the engraftment and survival of transplanted stem cells in mouse models of ischaemic injury.

    • Andrew S. Lee
    • , Mohammed Inayathullah
    • , Maarten A. Lijkwan
    • , Xin Zhao
    • , Wenchao Sun
    • , Sujin Park
    • , Wan Xing Hong
    • , Mansi B. Parekh
    • , Andrey V. Malkovskiy
    • , Edward Lau
    • , Xulei Qin
    • , Venkata Raveendra Pothineni
    • , Verónica Sanchez-Freire
    • , Wendy Y. Zhang
    • , Nigel G. Kooreman
    • , Antje D. Ebert
    • , Charles K. F. Chan
    • , Patricia K. Nguyen
    • , Jayakumar Rajadas
    •  & Joseph C. Wu
  • News & Views |

    The combination of ultrafast ultrasound and positron emission tomography–computed tomography enables the simultaneous 3D imaging of anatomy and metabolism at high resolution.

    • Mark Dewhirst
  • Editorial |

    The communication of research findings, in both written and oral forms, would benefit from concepts used in cinematographic storytelling.

  • Article |

    Cells engineered to produce an analgesic in response to spearmint aroma and implanted in mouse models of chronic pain reduce the pain-associated behaviour after oral intake of spearmint essential oil with no adverse effects.

    • Hui Wang
    • , Mingqi Xie
    • , Ghislaine Charpin-El Hamri
    • , Haifeng Ye
    •  & Martin Fussenegger
  • News & Views |

    Synthetic mammalian cells engineered to synthesize a painkiller in response to volatile spearmint reduce chronic pain in mice and do not seem to elicit adverse effects.

    • Daniel D. Lewis
    •  & Cheemeng Tan
  • Article |

    A system that combines positron emission tomography, computed tomography and ultrafast ultrasound allows for simultaneous multi-parametric imaging in animal models.

    • Jean Provost
    • , Anikitos Garofalakis
    • , Joevin Sourdon
    • , Damien Bouda
    • , Béatrice Berthon
    • , Thomas Viel
    • , Mailyn Perez-Liva
    • , Charlotte Lussey-Lepoutre
    • , Judith Favier
    • , Mafalda Correia
    • , Mathieu Pernot
    • , Johanna Chiche
    • , Jacques Pouysségur
    • , Mickael Tanter
    •  & Bertrand Tavitian
  • Review Article |

    This Review discusses technology for the isolation and phenotypic profiling of circulating tumour cells from blood for the identification of those with high metastatic potential as well as requirements for clinical applications of the cells.

    • Mahla Poudineh
    • , Edward H. Sargent
    • , Klaus Pantel
    •  & Shana O. Kelley
  • Article |

    A microtechnology involving force sensors embedded in elastomers for cell culture enables the high-throughput measurement of single-cell force generation from contractile cells in a scalable and highly parallelized manner.

    • Ivan Pushkarsky
    • , Peter Tseng
    • , Dylan Black
    • , Bryan France
    • , Lyndon Warfe
    • , Cynthia J. Koziol-White
    • , William F. Jester Jr
    • , Ryan K. Trinh
    • , Jonathan Lin
    • , Philip O. Scumpia
    • , Sherie L. Morrison
    • , Reynold A. Panettieri Jr
    • , Robert Damoiseaux
    •  & Dino Di Carlo
  • News & Views |

    Nanoparticles carrying an antibiotic and bearing a peptide that targets the bacterium Staphylococcus aureus effectively suppress staphylococcal infections in mice.

    • Li-Li Li
    •  & Hao Wang
  • News & Views |

    Single-cell traction-force measurements performed on fluorescently labelled elastomeric surfaces can probe the physiological and pathological behaviour of thousands of cells in a single experiment.

    • Agnes M. Resto-Irizarry
    •  & Jianping Fu
  • Article |

    Nanoparticles carrying an antibiotic and conjugated with a peptide identified via phage display that binds specifically to Staphylococcus aureus effectively suppress staphylococcal infections in vivo.

    • Sazid Hussain
    • , Jinmyoung Joo
    • , Jinyoung Kang
    • , Byungji Kim
    • , Gary B. Braun
    • , Zhi-Gang She
    • , Dokyoung Kim
    • , Aman P. Mann
    • , Tarmo Mölder
    • , Tambet Teesalu
    • , Santina Carnazza
    • , Salvatore Guglielmino
    • , Michael J. Sailor
    •  & Erkki Ruoslahti
  • Perspective |

    This Perspective argues that a significant number of bone fractures in the elderly are insufficiency fractures caused by cyclic loading from daily activities, which induces fatigue cracking, rather than the result of impacts or trauma.

    • Claire Acevedo
    • , Vincent A. Stadelmann
    • , Dominique P. Pioletti
    • , Tamara Alliston
    •  & Robert O. Ritchie
  • Editorial |

    The translational achievements, commercialization prospects and eventual clinical and societal impacts of biomedical work accrue over a long time. They should be better captured and publicized.

  • News & Views |

    Commensal microbes engineered to convert natural compounds found in cruciferous vegetables into molecules with anticancer properties prevent carcinogenesis and cause the regression of colorectal cancer in mice fed with a vegetable diet.

    • David A. Drew
    •  & Andrew T. Chan
  • News & Views |

    Occluders for the left atrial appendage that are patient-specific, thus ensuring better fitting and potentially less complications, can be made by 3D-printing inflatable polymer devices on the basis of data derived from computed tomography scans.

    • Carola Gianni
    •  & Andrea Natale
  • Article |

    Engineered commensal microbes that transform natural compounds present in cruciferous vegetables into an anticancer molecule prevent carcinogenesis and promote the regression of colorectal cancer in mice fed with the microbes and the vegetables.

    • Chun Loong Ho
    • , Hui Qing Tan
    • , Koon Jiew Chua
    • , Aram Kang
    • , Kiat Hon Lim
    • , Khoon Lin Ling
    • , Wen Shan Yew
    • , Yung Seng Lee
    • , Jean Paul Thiery
    •  & Matthew Wook Chang
  • Article |

    A cloud-based machine-learning software that scores individual guide–target pairs and provides an overall summary score for a given guide that outperforms competing algorithms for the prediction of CRISPR–Cas9 off-target effects.

    • Jennifer Listgarten
    • , Michael Weinstein
    • , Benjamin P. Kleinstiver
    • , Alexander A. Sousa
    • , J. Keith Joung
    • , Jake Crawford
    • , Kevin Gao
    • , Luong Hoang
    • , Melih Elibol
    • , John G. Doench
    •  & Nicolo Fusi
  • News & Views |

    Grafting platelet-derived nanovesicles onto the surface of cardiosphere-derived cardiac stem cells enables the cells to better engraft in infarcted tissue following systemic injection in rats and pigs.

    • Philippe Menasché
  • Article |

    The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.

    • Junnan Tang
    • , Teng Su
    • , Ke Huang
    • , Phuong-Uyen Dinh
    • , Zegen Wang
    • , Adam Vandergriff
    • , Michael T. Hensley
    • , Jhon Cores
    • , Tyler Allen
    • , Taosheng Li
    • , Erin Sproul
    • , Emily Mihalko
    • , Leonard J. Lobo
    • , Laura Ruterbories
    • , Alex Lynch
    • , Ashley Brown
    • , Thomas G. Caranasos
    • , Deliang Shen
    • , George A. Stouffer
    • , Zhen Gu
    • , Jinying Zhang
    •  & Ke Cheng
  • Publisher Correction |

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas
  • Publisher Correction |

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Raju Tomer
    • , Cecilia Sahlgren
    • , Pauliina Kronqvist
    • , Dagmara Kaczynska
    • , Lauri Louhivuori
    • , Lorand Kis
    • , Claes Lindh
    • , Przemysław Mitura
    • , Andrzej Stepulak
    • , Sara Corvigno
    • , Johan Hartman
    • , Patrick Micke
    • , Artur Mezheyeuski
    • , Carina Strell
    • , Joseph W. Carlson
    • , Carlos Fernández Moro
    • , Hanna Dahlstrand
    • , Arne Östman
    • , Kazuhiro Matsumoto
    • , Peter Wiklund
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Karl Deisseroth
    •  & Per Uhlén