A framework for integrating continuous therapeutic monitoring and the development of AI for clinical care may improve patient and health-system outcomes by tightening feedback loops between patient health, clinical interactions and the development of AI models.

This Perspective discusses progress in the development of robotic capsules for oral drug delivery and the challenges of realizing sophisticated multifunctional robotic pills that can function as closed-loop systems.

This Perspective discusses fairness in machine learning and how algorithmic biases arising in clinical workflows can cause healthcare disparities.

This Review discusses the characteristics of neural probes that are most likely to facilitate the clinical translation of invasive neural interfaces, the abiotic and biotic factors that contribute to their failure and emerging neural-interface architectures.

Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.

A wide-field fluorescence microscope leveraging a spinning disc and high-speed cameras enables the recording of neural activities and neutrophil trajectories at micrometric resolution on curved cortical surfaces in live mice.

Optimized base editors targeting the exon-7 mutation in SMN2 restore expression of the survival motor neuron (SMN) protein to normal levels, as shown in mice with spinal muscular atrophy and in fibroblasts from patients with this genetic disease.

A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.

The transplantation and long-term survival of hydrogel-encapsulated islets can be enhanced by first using a catheter to create a subcutaneous cavity and to trigger inflammation-induced local neovascularization.

A subcutaneous colon-specific niche consisting of colon epithelial cells, decellularized colon extracellular matrix and immunosuppressive nanofibres reduced inflammation in the gastrointestinal tract of mice with established ulcerative colitis.

Increasingly physiological in vitro models and techniques for measuring forces at multiple scales are enabling unanticipated findings in tissue mechanopathology.

The management of health and of disease conditions will eventually be supported by ever more integrated and less conspicuous wireless bioelectronic devices designed to continuously monitor multiple biomarkers.

Leverage curiosity, open-mindedness and the deliberate seeking of feedback.

Leveraging or improving established technology for clinical imaging to extract additional physiological information can enhance the quality of the subsequent assessments and widen the technology’s uses.

We provide a roadmap for overhauling faculty-hiring processes to eliminate barriers of entry to historically excluded groups.

Established reasoning behind yearly changes in impact factors is mostly flawed.