Ultrasound-mediated activation of CAR T cells within tumours

The November issue highlights T cells engineered to express a chimaeric antigen receptor within tumours when heat is locally generated by pulses of focused ultrasound.  


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  • The repertoire of new preclinical strategies for fighting tumours that resist or evade immunotherapy drugs and cellular immunotherapies is widening.

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  • Biomedical research needs upgraded standards for the monitoring, control and reporting of the environmental conditions of cells in culture.

  • The proposal for an Advanced Research Projects Agency for Health (ARPA-H) being considered by the United States Congress is bold and necessary, yet will require unrelenting focus, independence and a measured risk-taking culture.

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