Diemut Strebe

Kirigami shoe grips

The August issue highlights buckling kirigami structures that when placed on footwear outsoles generate friction forces for the mitigation of slipping and falling.

Latest Research

  • Article |

    Intratumoural injection of a self-assembling supramolecular hydrogel that slowly releases a STING agonist and a chemotherapeutic agent reduces tumour immunosuppression and increases antitumour responses in mice.

    • Feihu Wang
    • , Hao Su
    • , Dongqing Xu
    • , Wenbing Dai
    • , Weijie Zhang
    • , Zongyuan Wang
    • , Caleb F. Anderson
    • , Mengzhen Zheng
    • , Richard Oh
    • , Fengyi Wan
    •  & Honggang Cui
  • Article |

    Analyses of data from intracortical brain–computer interfaces implanted in rhesus macaques and in a human suggest that the circuit design parameters of current recording interfaces can be relaxed considerably without loss of performance.

    • Nir Even-Chen
    • , Dante G. Muratore
    • , Sergey D. Stavisky
    • , Leigh R. Hochberg
    • , Jaimie M. Henderson
    • , Boris Murmann
    •  & Krishna V. Shenoy
  • Article |

    An antibody-discovery pipeline integrating single-cell mRNA-sequence analysis, bioinformatics, synthetic biology and high-throughput functional analyses enables the rapid discovery of potent human monoclonal antibodies against viral pathogens.

    • Pavlo Gilchuk
    • , Robin G. Bombardi
    • , Jesse H. Erasmus
    • , Qing Tan
    • , Rachel Nargi
    • , Cinque Soto
    • , Peter Abbink
    • , Todd J. Suscovich
    • , Lorellin A. Durnell
    • , Amit Khandhar
    • , Jacob Archer
    • , Jenny Liang
    • , Mallorie E. Fouch
    • , Edgar Davidson
    • , Benjamin J. Doranz
    • , Taylor Jones
    • , Elise Larson
    • , Stacey Ertel
    • , Brian Granger
    • , Jasmine Fuerte-Stone
    • , Vicky Roy
    • , Thomas Broge
    • , Thomas C. Linnekin
    • , Caitlyn H. Linde
    • , Matthew J. Gorman
    • , Joseph Nkolola
    • , Galit Alter
    • , Steven G. Reed
    • , Dan H. Barouch
    • , Michael S. Diamond
    • , James E. Crowe Jr
    • , Neal Van Hoeven
    • , Larissa B. Thackray
    •  & Robert H. Carnahan
  • Article |

    Post-mortem histopathological data can be used to classify neuropathologies into six transdiagnostic clusters, and patient membership to these clusters can be predicted from cognitive scores, genotype and protein levels in cerebrospinal fluid.

    • Eli J. Cornblath
    • , John L. Robinson
    • , David J. Irwin
    • , Edward B. Lee
    • , Virginia M.-Y. Lee
    • , John Q. Trojanowski
    •  & Danielle S. Bassett
  • Article |

    T cells can be classified according to their activation state and subtype on the basis of their autofluorescence lifetime patterns.

    • Alex J. Walsh
    • , Katherine P. Mueller
    • , Kelsey Tweed
    • , Isabel Jones
    • , Christine M. Walsh
    • , Nicole J. Piscopo
    • , Natalie M. Niemi
    • , David J. Pagliarini
    • , Krishanu Saha
    •  & Melissa C. Skala
  • Article |

    The expression of therapeutic protein targets in circulating tumour cells isolated from blood samples of patients with cancer can be tracked at the single-cell level by antibody-mediated magnetic labelling and microfluidic sorting.

    • Mahmoud Labib
    • , Zongjie Wang
    • , Sharif U. Ahmed
    • , Reza M. Mohamadi
    • , Bill Duong
    • , Brenda Green
    • , Edward H. Sargent
    •  & Shana O. Kelley

News & Comment

  • News & Views |

    The cell-selective permeability of a retrievable microporous device encapsulating human therapeutic cells and implanted in the intraperitoneal space of mice provides long-term protection to the transplanted cells by dampening foreign-body responses and preventing the immune rejection of the graft.

    • Ken Coppieters
    • , Louise Winkel
    •  & Matthias von Herrath
  • News & Views |

    Positron emission tomography enables the tracking, in a mouse, of an intravenously injected cell radiolabelled with mesoporous silica nanoparticles containing 68Ga.

    • Guus A. M. S. van Dongen
    • , Ronald Boellaard
    •  & Danielle J. Vugts
  • Editorial |

    Results from the early trials of vaccine candidates against SARS-CoV-2 signal the fitness of vaccine technologies soon to be tested at scale.

  • News & Views |

    Lipofuscin, an endogenous pigment, can be used as a near-infrared fluorescent biomarker to stage and to monitor the progression of chronic liver disease, as shown in mice with induced liver disease and in human livers biopsied from patients with liver fibrosis.

    • Justin J. O’Sullivan
    • , Nathaniel H. O. Harder
    •  & Marie C. Heffern
  • News & Views |

    Neuropathologies can be classified, on the basis of post-mortem histopathology and by using machine learning, into six transdiagnostic clusters associated with clinical phenotypes.

    • Pablo Villoslada
    • , Ricardo Baeza-Yates
    •  & Joseph C. Masdeu
  • News & Views |

    Gold nanoclusters stabilized by the milk metalloprotein α-lactalbumin and displaying multicolour and multimodal fluorescence aid the detection, resection and treatment of breast tumours in mice.

    • Gang He
    • , Peng Huang
    •  & Xiaoyuan Chen

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