depicts the high correlations between predicted and actual age (purple and red lines), on top of a circle plot in which each sector represents an individual species, irrespective of differences in species maximum lifespans (dashed line).

Universal DNA methylation age across mammalian tissues

  • A. T. Lu
  • Z. Fei
  • S. Horvath


  • Nature Aging's editors have put together a list of conferences on aging and aging-related diseases in 2023. We look forward to meeting you at some of these conferences!

  • Nature Outlook: Ageing

    This Outlook on Ageing, a supplement to Nature, explores topics such as measuring biological age, super-centenarians, aging societies, and more.

  • Issue cover featuring an artistic depicting of a human brain with different parts in the share of jigsaw puzzle pieces

    Nature Aging published a special issue on the transforming landscape of dementia research. This Focus issue brings together a selection of Reviews, Perspectives and Comments on the most recent advances in our understanding of Alzheimer’s disease and other dementias, as well as the challenges in diagnosis, prevention and treatment of these diseases.

  • Nature Aging on PubMed

    Nature Aging is now officially accepted for MEDLINE indexing. All of the journal’s content will soon be visible and searchable on PubMed, in addition to Web of Science, Google Scholar, and Scopus.

Nature Aging is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Given the unique requirements of older adults, age-friendly product design is becoming increasingly important to promote independence and enhance quality of life. The Global Centre for Modern Ageing calls for a comprehensive, standardized and evidence-based assessment process to incorporate the perspectives of older adults into the design process.

    • Navaz Naghavi
    • Saeed Pahlevansharif
    World View
  • The intestinal epithelium serves as a barrier that facilitates interaction between intrinsic and environmental factors. Aging is accompanied by the gradual deterioration of this barrier. We postulate that barrier dysfunction results from defects in epithelial membrane trafficking that exacerbate age-related metabolic imbalances. Herein, we integrate barrier integrity, protein homeostasis, membrane trafficking and intracellular lipid sensing into an age-determining mechanism.

    • Lexus Tatge
    • Rene Solano Fonseca
    • Peter M. Douglas
  • Aging is a major risk factor for vascular disease. Increased levels of milk fat globule-EGF factor 8 (MFG-E8) are associated with many age-related arterial changes, but the mechanisms remain unclear. We propose that these detrimental effects may result from medin, a fragment of MFG-E8 that forms a highly common vascular amyloid.

    • Jillian Madine
    • Hannah A. Davies
    • Jonas J. Neher


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