First issue now live!

Nature Aging is an online-only thematic journal publishing research articles, reviews, news and opinion pieces from across the broad field of aging research.

Latest Issue

Nature Aging is a Transformative Journal; authors can publish using the traditional publishing route OR Open Access.
Our Open Access option complies with funder and institutional requirements.

Latest Research

  • Perspective |

    Linda Fried and colleagues argue that physical frailty reflects the dysregulation of a complex dynamical system underpinning health and resilience, and discuss the implications for new prevention and treatment approaches.

    • Linda P. Fried
    • , Alan A. Cohen
    • , Qian-Li Xue
    • , Jeremy Walston
    • , Karen Bandeen-Roche
    •  & Ravi Varadhan
  • Perspective |

    In this Perspective, Rando and Wyss-Coray discuss recent advances in the field of the biology of aging, focusing on new concepts related to the processes of cell and tissue aging and how they impact the healthspan and lifespan of an individual.

    • Thomas A. Rando
    •  & Tony Wyss-Coray
  • Review Article |

    Intermittent and periodic fasting are emerging as important interventions with the potential to extend longevity and healthspan. This Review discusses how they affect longevity and healthspan in model organisms and humans, their connection to major nutrient-sensing signaling pathways and the importance of refeeding.

    • Valter D. Longo
    • , Maira Di Tano
    • , Mark P. Mattson
    •  & Novella Guidi
  • Article |

    Using metagenomics sequencing, Zhang et al. examined sex- and age-dependent trajectories of the gut microbiota in four cohorts across China, Israel and the Netherlands. The authors found age-related gut microbial trajectories common across all populations, with the abundance of Streptococcus gordonii predicting chronological age.

    • Xiuying Zhang
    • , Huanzi Zhong
    • , Yufeng Li
    • , Zhun Shi
    • , Huahui Ren
    • , Zhe Zhang
    • , Xianghai Zhou
    • , Shanmei Tang
    • , Xueyao Han
    • , Yuxiang Lin
    • , Fangming Yang
    • , Dan Wang
    • , Chao Fang
    • , Zuodi Fu
    • , Lianying Wang
    • , Shida Zhu
    • , Yong Hou
    • , Xun Xu
    • , Huanming Yang
    • , Jian Wang
    • , Karsten Kristiansen
    • , Junhua Li
    •  & Linong Ji
  • Article |

    The authors show that cutaneous immunity is attenuated during aging due to the recruitment, by senescent fibroblasts, of inflammatory monocytes, which in turn inhibit resident memory T cell activation. Inhibition of p38 MAPK signaling blocks the recruitment and function of these monocytes and restores immunity.

    • Emma S. Chambers
    • , Milica Vukmanovic-Stejic
    • , Barbara B. Shih
    • , Hugh Trahair
    • , Priya Subramanian
    • , Oliver P. Devine
    • , James Glanville
    • , Derek Gilroy
    • , Malcolm H. A. Rustin
    • , Tom C. Freeman
    • , Neil A. Mabbott
    •  & Arne N. Akbar
  • Article |

    The authors find that mice fed a diet with reduced levels of branched-chain amino acids have improved metabolic health, and in males but not females, lifelong feeding of such a diet reduces frailty and extends life span.

    • Nicole E. Richardson
    • , Elizabeth N. Konon
    • , Haley S. Schuster
    • , Alexis T. Mitchell
    • , Colin Boyle
    • , Allison C. Rodgers
    • , Megan Finke
    • , Lexington R. Haider
    • , Deyang Yu
    • , Victoria Flores
    • , Heidi H. Pak
    • , Soha Ahmad
    • , Sareyah Ahmed
    • , Abigail Radcliff
    • , Jessica Wu
    • , Elizabeth M. Williams
    • , Lovina Abdi
    • , Dawn S. Sherman
    • , Timothy A. Hacker
    •  & Dudley W. Lamming

News & Comment

  • Editorial |

    We are excited to launch Nature Aging, a journal whose mission is to publish some of the most important and timely research from across the entire aging research spectrum and be a nexus for the diverse communities working on aging.

  • Comment |

    As a physician scientist caring for older adults in New York City during the peak of the COVID-19 pandemic, I reflect on my experiences, the stark contrast in resource availability between hospitals and nursing homes, and the scientific opportunities and challenges for aging research.

    • Mark S. Lachs
  • Comment |

    Recent advances in deep learning enabled the development of AI systems that outperform humans in many tasks and have started to empower scientists and physicians with new tools. In this Comment, we discuss how recent applications of AI to aging research are leading to the emergence of the field of longevity medicine.

    • Alex Zhavoronkov
    • , Evelyne Bischof
    •  & Kai-Fu Lee