Flies glowing softly against the night sky, with a stronger glow within an open glass jar

Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system


  • Pingze Zhang
  • James H. Catterson
  • Linda Partridge


  • Dementia conference in Africa

    The first-ever Nature Dementia conference to be held on the African continent is taking place September 11th - 12th, 2024 in Nairobi, Kenya. The event will be convened by Nature Conferences, the Davos Alzheimer's Collaborative, and Aga Khan University.

  • Nature awards microbiome accelerator

    The Accelerator will identify microbiome research with the potential to transform human health outcomes. Four carefully chosen applicants will be awarded $10,000 and gain entry to our immersive residential programme that provides the training/mentorship, and connections to translate groundbreaking research for maximum impact. Deadline for applications is 24 June 2024.

  • Issue cover featuring an artistic depicting of a human brain with different parts in the share of jigsaw puzzle pieces

    Nature Aging published a special issue on the transforming landscape of dementia research. This Focus issue brings together a selection of Reviews, Perspectives and Comments on the most recent advances in our understanding of Alzheimer’s disease and other dementias, as well as the challenges in diagnosis, prevention and treatment of these diseases.

Nature Aging is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • Aging-related DNA methylation changes are numerous. Their precise measurement has opened new avenues to explore aging-related disease pathology, including the construction of chronological and biological age predictors (termed DNA methylation ‘clocks’). Three studies investigate the substantial stochastic contribution to these epigenetic changes and further our understanding of aging biology, as well as of these predictors.

      • Christopher G. Bell
      News & Views
    • Zou and colleagues design and analyze a health education program that targeted college students (who were grandchildren) to encourage older persons who had already had their first COVID-19 vaccine dose to receive a booster. The program increased the uptake of booster doses, which highlights the fact that family ties can have positive roles in the context of a pandemic.

      • Bruno Arpino
      News & Views
    • Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.

      • Ariane Zamoner
      • Pedro Fontes Oliveira
      • Marco G. Alves
      News & Views
    • Skeletal muscle is a highly heterogenous tissue that comprises multiple cell types. Leveraging single-cell and single-nucleus experiments, we systematically mapped the cellular and molecular changes across different skeletal muscle compartments with age. We identify neuromuscular-junction accessory nuclei that may be pivotal in mitigating denervation and uncovered differences between myofiber and myonucleus aging.

      Research Briefing
    • The advent of plaque-clearing antibodies to the amyloid-β as the first disease-modifying treatment for Alzheimer’s disease will change the course of this disease, the most common type of dementia. Related progress will gradually alter the trajectory of human aging.

      • Dennis J. Selkoe


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