Short-term air pollution and cognitive health

  • Xu Gao
  • Brent Coull
  • Andrea A. Baccarelli
Letter

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    • Chronic inflammation, or ‘inflammaging’, is a key process in age-related diseases, and identification of the molecular players involved is a top priority. Cai and Han identified an evolutionary conserved functional lncRNA able to modulate the release of inflammatory SASP molecules from senescent cells through the NF-κB pathway.

      • Rosario Avolio
      • Elias Bechara
      • Gian Gaetano Tartaglia
      News & Views
    • The tumor microenvironment (TME) impacts different phases of tumor progression and therapy resistance. Zhang et al. show that senescent stromal cells activate an epigenetic program that controls the senescence-associated secretory phenotype and can be targeted to boost responses to chemotherapy.

      • Maria Andrea Desbats
      • Sara Zumerle
      • Andrea Alimonti
      News & Views
    • Long-term exposure to air pollution is harmful to human health, causing damage to respiratory and cardiovascular systems. A new study provides evidence that even short-term, relatively low-level air pollution can be detrimental for cognitive function, and suggests the possibility that a commonly used drug might help reduce the harmful effects.

      • Joanne Ryan
      • Alice J. Owen
      News & Views
    • Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.

      • Ingrid Meulenbelt
      • Yolande F. M. Ramos
      • D. Michiel Pegtel
      News & Views
  • The editors speak to Louise Aronson, geriatrician and Pulitzer Prize finalist, about how old age is perceived and defined, and the influence of social determinants on health. Aronson reflects on her experiences caring and advocating for older adults, and outlines some of the challenges to be addressed during the UN Decade of Healthy Aging.

    • Briony Jain
    Q&A
  • The pandemic has highlighted the need for stronger intergenerational connections. Restarting intergenerational programs and expanding newer initiatives to connect people of different ages must be prioritized in debates about how society should progress post-pandemic.

    Editorial
  • There is a major and rapidly growing deficiency in the US eldercare workforce at all levels, especially among physicians. Efforts to increase recruitment and retention into geriatrics have failed, especially among critically important educators and researchers. Possible strategies to assure adequate care for older persons are discussed.

    • John W. Rowe
    Comment
  • The latest spat over the potential approval of aducanumab, an amyloid-β-targeting drug for Alzheimer’s disease, highlights continuing controversy over the amyloid-β hypothesis.

    • Mark Zipkin
    News Feature