Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARα-targeted microRNAs. They demonstrate the therapeutic potential of intervening in this process using the PPARα agonist fenofibrate.

Oocyte quality declines during aging. Here the authors show that oocytes from aged mice cultured within follicles from young mice have improved developmental potential. Aged oocytes cultured within young follicles have enhanced interaction with somatic cells, improved mitochondrial function and better meiotic chromosome segregation.

Meguro et al. show an accumulation of p16^high senescent fibroblasts in the aging bladder that serves as a cancer-permissive niche and promotes tumor growth by secreting CXCL12. Inhibition of senescence or CXCL12 signaling suppresses bladder tumor growth.

Age-related loss of gene expression coordination may contribute to impaired cellular function. In this study, the authors analyzed age-related trends in gene–gene relationships. They found that expression control often remains intact among genes involved in shared cellular functions while the coordination between functions tends to decline.

In the twentieth century, human life expectancy rose dramatically. Based on the past three decades of observed mortality in the eight countries with the longest-lived populations and in Hong Kong and the United States, Olshansky et al. propose that, without medical breakthroughs that slow aging, radical lifespan extension is implausible in this century.

Epigenetic clocks estimate biological age; however, the underlying processes are incompletely understood. Here the authors developed a model that describes methylation changes at the cellular level to provide a biologically interpretable predictor of epigenetic age. They reveal acceleration and bias components, and links with health traits.

Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARα-targeted microRNAs. They demonstrate the therapeutic potential of intervening in this process using the PPARα agonist fenofibrate.

Oocyte quality declines during aging. Here the authors show that oocytes from aged mice cultured within follicles from young mice have improved developmental potential. Aged oocytes cultured within young follicles have enhanced interaction with somatic cells, improved mitochondrial function and better meiotic chromosome segregation.

Meguro et al. show an accumulation of p16^high senescent fibroblasts in the aging bladder that serves as a cancer-permissive niche and promotes tumor growth by secreting CXCL12. Inhibition of senescence or CXCL12 signaling suppresses bladder tumor growth.

Age-related loss of gene expression coordination may contribute to impaired cellular function. In this study, the authors analyzed age-related trends in gene–gene relationships. They found that expression control often remains intact among genes involved in shared cellular functions while the coordination between functions tends to decline.

Pioneer of cell aging research and discoverer of the Hayflick limit.