Volume 3 Issue 6, June 2023

Liu and colleagues investigate the effects that ovarian aging may have in granulosa cell-to-oocyte communication and demonstrate that oocyte rejuvenation and the extension of reproductive lifespan is possible by increasing lipid metabolism in granulosa cells in mouse.

Quantification of tau peptides in blood samples using a new mass spectrometry method suggests that individual phosphorylated tau peptides have distinct patterns of emergence in Alzheimer’s disease and differential associations with amyloid and tau pathologies. This method has the potential to stage patients along the disease continuum and for clinical trials.

We used graph neural networks trained on experimental data to identify senolytic compounds from vast chemical libraries of over 800,000 compounds and discovered structurally diverse senolytics that have potent in vitro and in vivo activity, as well as favorable medicinal chemistry properties.

Lamming and Mannick discuss work over the past decade showing that rapamycin promotes survival in multiple species and how recent clinical trials have finally begun to explore whether existing mTOR inhibitors can safely prevent, delay or treat multiple diseases of aging in humans.

A mass spectrometric analysis of plasma tau species identifies phosphorylated tau peptides p-tau217, p-tau231 and p-tau205 with distinct correlations with amyloid and tau pathologies and emergences along the AD continuum.

Oocyte meiotic defects increase with age and contribute to decreased oocyte quality. Here the authors show that granulosa cell mevalonate pathway abnormalities contribute to aneuploidy during ovarian aging and that supplementation with mevalonate metabolites improves oocyte quality, providing a potential therapeutic strategy for promoting female reproductive longevity.

Solá, Mereu and colleagues describe a chronic inflammatory state in the aging mouse skin that is characterized by IL-17 production by dermal lymphoid cells and demonstrate the potential of inhibition of IL-17 signaling in protection against skin aging.

The authors characterized m⁶A dynamics in primate tissue aging and revealed a new role for the METTL3–m⁶A–NPNT axis in maintaining skeletal muscle homeostasis, thereby providing insight into the epitranscriptomic machinery underlying primate aging.

Although vaccination drops COVID-19 mortality in older adults, post-vaccine fatal COVID-19 in nursing home outbreaks was linked to Delta, Gamma and Mu variants, persistently detected in aerosols. Mortality was predicted by IFNB1 or age, ORF7a and ACE2 mRNAs.

Senolytic compounds have shown promise for the treatment of aging-related diseases in animal models. Here, to discover new small molecule senolytics, Wong, Omori and colleagues introduce a graph neural network platform, identify structurally diverse compounds with favorable drug-like properties and confirm one compound’s in vivo activity in aged mice.