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Volume 2 Issue 10, October 2022

Autoimmunity in dementia

In this issue, Lindbohm and colleagues provide several lines of analysis which suggest that autoimmunity is a modifiable component in dementia-causing diseases. The cover image illustrates immune cell activation and inflammation that weakens the blood–brain barrier (below), which allows infiltration of immune cells into the central nervous system (above).

See Lindbohm et al.

Cover image: Dr. Behnoush Hajian, Broad Institute of MIT and Harvard. Cover design: Lauren Heslop


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Comment & Opinion

  • The aging research field has largely focused on reversing aging-related changes in the body. However, emerging evidence about the gut microbiome indicates that it may not be optimal to just turn back the clock. Here, we advocate for a more tailored and function-focused approach promoting health across the lifespan.

    • Tomasz Wilmanski
    • Sean M. Gibbons
    • Nathan D. Price
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Research Highlights

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News & Views

  • A new study shows that decreased cystatin A synthesis in aged epidermis mediates age-related bone loss, whereas topical treatment that restores cystatin A mitigates this loss. This report demonstrates that skin aging has systemic consequences by showing that signals originating in skin can control bone function.

    • Theodora Mauro
    • Daniel Bikle
    News & Views
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Research Briefings

  • Our longitudinal study comparing the skin, gut and oral microbiomes of community-dwelling older adults and nursing home residents showed striking changes known to be linked to antibiotic resistance and disease risk. Such shifts were associated with frailty, not chronological age, and were most pronounced in the skin, the primary reservoir for infection risk.

    Research Briefing
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  • In this Perspective, Jan Vijg and Brandon Milholland discuss that at high ages the probability of survival becomes vanishingly small, presenting a soft limit to human lifespan. They elaborate on the mechanistic basis of the observed limit to maximum human lifespan, and on the seemingly impossible future developments required to circumvent the current limit.

    • Brandon Milholland
    • Jan Vijg
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