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Volume 1 Issue 7, July 2021

Aging well for Australia’s First Nations

The July cover features artwork by an Indigenous Australian artist, Danielle Burford, who describes the work as “a tribute to one of our oldest living reptiles, the green sea turtle, elders of the sea, who carry with them the wisdom of ages. A journey of life connected to the sea and knowledge passed down through generations, as is our culture”. The artwork was selected for inclusion in the project report Sharing the Wisdom of Our Elders to represent the themes identified in the Koori Growing Old Well Study ( Two of the project’s investigators from Neuroscience Research Australia (NeuRA) have penned a World View article on aging well among Indigenous Australians, which is featured in this issue of Nature Aging.

See World View

Image: Artwork by Danielle Burford. Cover design: Lauren Heslop.


  • The recent approval of a new drug for Alzheimer’s disease despite weak evidence of efficacy sent shockwaves throughout the scientific community. The approval leaves many open questions in its trail that must now be addressed.



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Comment & Opinion

  • Indigenous Australians, one of the oldest living civilizations in the world, are growing older despite centuries of health and social inequity. Further improvements in longevity and aging will require a life-course approach and community-led initiatives.

    • Kylie Radford
    • Gail Garvey
    World View
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News & Views

  • Nursing home residents account for 41% of all COVID-19 deaths. Understanding why this occurs and the interplay between infectious agent, person, nursing home environment and operations, and public health responses is essential for families and governments when making decisions to protect loved ones and citizens, respectively.

    • Joseph E. Ibrahim
    News & Views
  • Inflammation is known to be elevated with progressive age. In this issue, Sayed et al. identify a group of circulating cytokines that correlate with health decline in aging, particularly the chemokine CXCL9. The findings offer a new understanding of how wellbeing and biological resilience are independent from chronological age.

    • M. Luisa Iruela-Arispe
    News & Views
  • The first longevity revolution led to lifespan extension. The next revolution will extend healthspan through the development of aging therapeutics. A new study describes the economic impact of success and how these interventions will work by analysing various scenarios labeled after characters from popular literature.

    • S. Jay Olshansky
    News & Views
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  • The authors show that glial AP1 is initially protective after traumatic brain injury (TBI) but remains active chronically, driving tau pathology and degeneration. Glial AP1 similarly activates with normal aging, suggesting this may be accelerated by TBI.

    • China N. Byrns
    • Janani Saikumar
    • Nancy M. Bonini
  • From the blood immunome of 1,001 individuals aged 8–96 years, the authors used deep learning to develop an inflammatory clock of aging (iAge) that tracks with multimorbidity, immunosenescence, frailty and cardiovascular aging, and is also associated with exceptional longevity in centenarians. The main contributor to iAge is the chemokine CXCL9, which is shown to control endothelial cell senescence and function.

    • Nazish Sayed
    • Yingxiang Huang
    • David Furman

    Nature Outlook:

  • An economic analysis suggests that targeting aging offers potentially larger economic gains than eradicating individual diseases. Slowing aging to increase life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion.

    • Andrew J. Scott
    • Martin Ellison
    • David A. Sinclair
    Analysis Open Access
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Amendments & Corrections

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